Brad S. Rothberg
Brad S. Rothberg
Professor of Medical Genetics & Molecular Biochemistry, Temple University School of Medicine
Verified email at temple.edu
TitleCited byYear
STIM proteins: dynamic calcium signal transducers
J Soboloff, BS Rothberg, M Madesh, DL Gill
Nature reviews Molecular cell biology 13 (9), 549, 2012
4942012
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca2+ uptake that regulates cell survival
K Mallilankaraman, P Doonan, C Cárdenas, HC Chandramoorthy, ...
Cell 151 (3), 630-644, 2012
3782012
Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate
KS Shin, BS Rothberg, G Yellen
The Journal of general physiology 117 (2), 91-102, 2001
1732001
Voltage and Ca2+ activation of single large-conductance Ca2+-activated K+ channels described by a two-tiered allosteric gating mechanism
BS Rothberg, KL Magleby
The Journal of general physiology 116 (1), 75-100, 2000
1532000
Gating Kinetics of Single Large-Conductance Ca2+-Activated K+ Channels in High Ca2+ Suggest a Two-Tiered Allosteric Gating Mechanism✪
BS Rothberg, KL Magleby
The Journal of general physiology 114 (1), 93-124, 1999
1361999
Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site
X Wang, Y Wang, Y Zhou, E Hendron, S Mancarella, MD Andrake, ...
Nature communications 5, 3183, 2014
1142014
Mechanism of β4 subunit modulation of BK channels
B Wang, BS Rothberg, R Brenner
The Journal of general physiology 127 (4), 449-465, 2006
1072006
Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage
KS Shin, C Maertens, C Proenza, BS Rothberg, G Yellen
Neuron 41 (5), 737-744, 2004
1062004
Voltage-controlled gating at the intracellular entrance to a hyperpolarization-activated cation channel
BS Rothberg, KS Shin, PS Phale, G Yellen
The Journal of general physiology 119 (1), 83-91, 2002
1052002
Kinetic structure of large-conductance Ca2+-activated K+ channels suggests that the gating includes transitions through intermediate or secondary states: A mechanism for flickers
BS Rothberg, KL Magleby
The Journal of general physiology 111 (6), 751-780, 1998
581998
Orai channel pore properties and gating by STIM: implications from the Orai crystal structure
BS Rothberg, Y Wang, DL Gill
Sci. Signal. 6 (267), pe9-pe9, 2013
552013
A role for the S0 transmembrane segment in voltage-dependent gating of BK channels
OM Koval, Y Fan, BS Rothberg
The Journal of general physiology 129 (3), 209-220, 2007
532007
STIM1 dimers undergo unimolecular coupling to activate Orai1 channels
Y Zhou, X Wang, X Wang, NA Loktionova, X Cai, RM Nwokonko, E Vrana, ...
Nature communications 6, 8395, 2015
492015
Mechanism of increased BK channel activation from a channel mutation that causes epilepsy
B Wang, BS Rothberg, R Brenner
The Journal of general physiology 133 (3), 283-294, 2009
492009
Movements near the gate of a hyperpolarization-activated cation channel
BS Rothberg, KS Shin, G Yellen
The Journal of general physiology 122 (5), 501-510, 2003
462003
The BK channel: a vital link between cellular calcium and electrical signaling
BS Rothberg
Protein & cell 3 (12), 883-892, 2012
442012
The STIM1-binding site nexus remotely controls Orai1 channel gating
Y Zhou, X Cai, NA Loktionova, X Wang, RM Nwokonko, X Wang, Y Wang, ...
Nature communications 7, 13725, 2016
412016
High Ca2+ concentrations induce a low activity mode and reveal Ca2 (+)‐independent long shut intervals in BK channels from rat muscle.
BS Rothberg, RA Bello, L Song, KL Magleby
The Journal of physiology 493 (3), 673-689, 1996
381996
Structure and function of multiple Ca2+-binding sites in a K+ channel regulator of K+ conductance (RCK) domain
VPT Pau, FJ Smith, AB Taylor, LV Parfenova, E Samakai, MM Callaghan, ...
Proceedings of the National Academy of Sciences 108 (43), 17684-17689, 2011
332011
Two-dimensional components and hidden dependencies provide insight into ion channel gating mechanisms
BS Rothberg, RA Bello, KL Magleby
Biophysical journal 72 (6), 2524-2544, 1997
291997
The system can't perform the operation now. Try again later.
Articles 1–20