| PhysiCell: An open source physics-based cell simulator for 3-D multicellular systems A Ghaffarizadeh, R Heiland, SH Friedman, SM Mumenthaler, P Macklin PLoS computational biology 14 (2), e1005991, 2018 | 360 | 2018 |
| A physical sciences network characterization of non-tumorigenic and metastatic cells Scientific reports 3 (1), 1449, 2013 | 170 | 2013 |
| Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes SM Mumenthaler, PYB Ng, A Hodge, D Bearss, G Berk, S Kanekal, ... Molecular cancer therapeutics 8 (10), 2882-2893, 2009 | 156 | 2009 |
| The impact of microenvironmental heterogeneity on the evolution of drug resistance in cancer cells SM Mumenthaler, J Foo, NC Choi, N Heise, K Leder, DB Agus, W Pao, ... Cancer informatics 14, CIN. S19338, 2015 | 103 | 2015 |
| 3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration H Wang, PC Brown, ECY Chow, L Ewart, SS Ferguson, S Fitzpatrick, ... Clinical and translational science 14 (5), 1659-1680, 2021 | 87 | 2021 |
| MALDI mass spectrometry imaging for evaluation of therapeutics in colorectal tumor organoids X Liu, C Flinders, SM Mumenthaler, AB Hummon Journal of the American Society for Mass Spectrometry 29 (3), 516-526, 2017 | 67 | 2017 |
| 17β-estradiol prevents early-stage atherosclerosis in estrogen receptor-alpha deficient female mice AC Villablanca, A Tenwolde, M Lee, M Huck, S Mumenthaler, ... Journal of cardiovascular translational research 2, 289-299, 2009 | 67 | 2009 |
| Evolutionary modeling of combination treatment strategies to overcome resistance to tyrosine kinase inhibitors in non-small cell lung cancer SM Mumenthaler, J Foo, K Leder, NC Choi, DB Agus, W Pao, P Mallick, ... Molecular pharmaceutics 8 (6), 2069-2079, 2011 | 65 | 2011 |
| A high-content image-based method for quantitatively studying context-dependent cell population dynamics CM Garvey, E Spiller, D Lindsay, CT Chiang, NC Choi, DB Agus, ... Scientific reports 6 (1), 29752, 2016 | 64 | 2016 |
| Expression of arginase II in prostate cancer SM Mumenthaler, H Yu, S Tze, SD Cederbaum, AE Pegg, DB Seligson, ... International journal of oncology 32 (2), 357-365, 2008 | 62 | 2008 |
| MALDI-MSI of immunotherapy: mapping the EGFR-targeting antibody cetuximab in 3D colon-cancer cell cultures X Liu, JK Lukowski, C Flinders, S Kim, RA Georgiadis, SM Mumenthaler, ... Analytical chemistry 90 (24), 14156-14164, 2018 | 52 | 2018 |
| Clocking cancer: the circadian clock as a target in cancer therapy F Battaglin, P Chan, Y Pan, S Soni, M Qu, ER Spiller, S Castanon, ... Oncogene 40 (18), 3187-3200, 2021 | 51 | 2021 |
| Comparison of cell and organoid-level analysis of patient-derived 3D organoids to evaluate tumor cell growth dynamics and drug response S Kim, S Choung, RX Sun, N Ung, N Hashemi, EJ Fong, R Lau, E Spiller, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (7), 744-754, 2020 | 47 | 2020 |
| CD4+ NK cells can be productively infected with HIV, leading to downregulation of CD4 expression and changes in function HB Bernstein, G Wang, MC Plasterer, JA Zack, P Ramasastry, ... Virology 387 (1), 59-66, 2009 | 47 | 2009 |
| Anti-EGFR therapy induces EGF secretion by cancer-associated fibroblasts to confer colorectal cancer chemoresistance CM Garvey, R Lau, A Sanchez, RX Sun, EJ Fong, ME Doche, O Chen, ... Cancers 12 (6), 1393, 2020 | 44 | 2020 |
| A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice C Quach, Y Song, H Guo, S Li, H Maazi, M Fung, N Sands, D O’Connell, ... Nature Communications 10 (1), 5681, 2019 | 43 | 2019 |
| Progress towards computational 3-d multicellular systems biology P Macklin, HB Frieboes, JL Sparks, A Ghaffarizadeh, SH Friedman, ... Systems biology of tumor microenvironment: Quantitative modeling and …, 2016 | 38 | 2016 |
| Anti-MET ImmunoPET for Non–Small Cell Lung Cancer Using Novel Fully Human Antibody Fragments K Li, R Tavaré, KA Zettlitz, SM Mumenthaler, P Mallick, Y Zhou, JD Marks, ... Molecular cancer therapeutics 13 (11), 2607-2617, 2014 | 38 | 2014 |
| Human colorectal cancer-on-chip model to study the microenvironmental influence on early metastatic spread C Strelez, S Chilakala, K Ghaffarian, R Lau, E Spiller, N Ung, D Hixon, ... Iscience 24 (5), 2021 | 34 | 2021 |
| Leveraging hypoxia-activated prodrugs to prevent drug resistance in solid tumors D Lindsay, CM Garvey, SM Mumenthaler, J Foo PLoS computational biology 12 (8), e1005077, 2016 | 28 | 2016 |
