Philip Tsichlis or Philip N Tsichlis
Philip Tsichlis or Philip N Tsichlis
Professor of Cancer Biology and Genetics, Ohio State University
Verified email at
Cited by
Cited by
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
TF Franke, SI Yang, TO Chan, K Datta, A Kazlauskas, DK Morrison, ...
Cell 81 (5), 727-736, 1995
A Retroviral Oncogene, akt, Encoding a Serine-Threonine Kinase Containing an SH2-Like Region
A Bellacosa, JR Testa, SP Staal, PN Tsichlis
Science 254 (5029), 274-277, 1991
The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.
SG Kennedy, AJ Wagner, SD Conzen, J Jordan, A Bellacosa, PN Tsichlis, ...
Genes & development 11 (6), 701-713, 1997
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
HA Hirsch, D Iliopoulos, PN Tsichlis, K Struhl
Cancer research 69 (19), 7507-7511, 2009
AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation
TO Chan, SE Rittenhouse, PN Tsichlis
Annual review of biochemistry 68 (1), 965-1014, 1999
TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway
CD Dumitru, JD Ceci, C Tsatsanis, D Kontoyiannis, K Stamatakis, JH Lin, ...
Cell 103 (7), 1071-1083, 2000
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.
JQ Cheng, AK Godwin, A Bellacosa, T Taguchi, TF Franke, TC Hamilton, ...
Proceedings of the National Academy of Sciences 89 (19), 9267-9271, 1992
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer
G Viglietto, ML Motti, P Bruni, RM Melillo, A D'alessio, D Califano, F Vinci, ...
Nature medicine 8 (10), 1136-1144, 2002
The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
SJ Grille, A Bellacosa, J Upson, AJ Klein-Szanto, F Van Roy, W Lee-Kwon, ...
Cancer research 63 (9), 2172-2178, 2003
Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway
T Skorski, A Bellacosa, M Nieborowska-Skorska, M Majewski, R Martinez, ...
The EMBO journal 16 (20), 6151-6161, 1997
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function
AD Basso, DB Solit, G Chiosis, B Giri, P Tsichlis, N Rosen
Journal of Biological Chemistry 277 (42), 39858-39866, 2002
Akt activation by growth factors is a multiple-step process: the role of the PH domain
A Bellacosa, TO Chan, NN Ahmed, K Datta, S Malstrom, D Stokoe, ...
Oncogene 17 (3), 313-325, 1998
Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway
RC Muise-Helmericks, HL Grimes, A Bellacosa, SE Malstrom, PN Tsichlis, ...
Journal of Biological Chemistry 273 (45), 29864-29872, 1998
The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs
A Androulidaki, D Iliopoulos, A Arranz, C Doxaki, S Schworer, ...
Immunity 31 (2), 220-231, 2009
Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase
NN Ahmed, HL Grimes, A Bellacosa, TO Chan, PN Tsichlis
Proceedings of the National Academy of Sciences 94 (8), 3627-3632, 1997
AKT1/PKBα kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells
M Sun, G Wang, JE Paciga, RI Feldman, ZQ Yuan, XL Ma, SA Shelley, ...
The American journal of pathology 159 (2), 431-437, 2001
Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation
WG King, MD Mattaliano, TO Chan, PN Tsichlis, JS Brugge
Molecular and cellular biology, 1997
Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase
HW Chang, M Aoki, D Fruman, KR Auger, A Bellacosa, PN Tsichlis, ...
Science 276 (5320), 1848-1850, 1997
Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization
A Arranz, C Doxaki, E Vergadi, Y Martinez de la Torre, K Vaporidi, ...
Proceedings of the National Academy of Sciences 109 (24), 9517-9522, 2012
Tcl1 enhances Akt kinase activity and mediates its nuclear translocation
Y Pekarsky, A Koval, C Hallas, R Bichi, M Tresini, S Malstrom, G Russo, ...
Proceedings of the National Academy of Sciences 97 (7), 3028-3033, 2000
The system can't perform the operation now. Try again later.
Articles 1–20