| New perspectives on how to discover drugs from herbal medicines: CAM's outstanding contribution to modern therapeutics SY Pan, SF Zhou, SH Gao, ZL Yu, SF Zhang, MK Tang, JN Sun, DL Ma, ... Evidence-Based Complementary and Alternative Medicine 2013, 2013 | 667 | 2013 |
| Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo R Pi, X Mao, X Chao, Z Cheng, M Liu, X Duan, M Ye, X Chen, Z Mei, P Liu, ... PLoS One 7 (2), e31921, 2012 | 327 | 2012 |
| Beneficial effects of the converting enzyme inhibitor, ramipril, in ischemic rat hearts. W Linz, BA Schölkens, YF Han Journal of cardiovascular pharmacology 8, S91-9, 1986 | 274 | 1986 |
| Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis PR Carlier, YF Han, ESH Chow, CPL Li, H Wang, TX Lieu, HS Wong, ... Bioorganic & medicinal chemistry 7 (2), 351-357, 1999 | 215 | 1999 |
| SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson’s disease W Wang, L Shi, Y Xie, C Ma, W Li, X Su, S Huang, R Chen, Z Zhu, Z Mao, ... Neuroscience research 48 (2), 195-202, 2004 | 198 | 2004 |
| Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways Z Zhang, W Cui, G Li, S Yuan, D Xu, MPM Hoi, Z Lin, J Dou, Y Han, ... Journal of agricultural and food chemistry 60 (33), 8171-8182, 2012 | 184 | 2012 |
| Minocycline prevents glutamate‐induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways R Pi, W Li, NTK Lee, HHN Chan, Y Pu, LN Chan, NJ Sucher, DC Chang, ... Journal of neurochemistry 91 (5), 1219-1230, 2004 | 184 | 2004 |
| Inhibition of glycogen synthase kinase-3β protects dopaminergic neurons from MPTP toxicity W Wang, Y Yang, C Ying, W Li, H Ruan, X Zhu, Y You, Y Han, R Chen, ... Neuropharmacology 52 (8), 1678-1684, 2007 | 183 | 2007 |
| Pharmacological profile of huperzine A, a novel acetylcholinesterase inhibitor from Chinese herb XC Tang, YF Han CNS Drug Reviews 5 (3), 281-300, 1999 | 180 | 1999 |
| Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity WJ Du, JJ Guo, MT Gao, SQ Hu, XY Dong, YF Han, FF Liu, S Jiang, Y Sun Scientific reports 5, 7992, 2015 | 179 | 2015 |
| Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand− peripheral site interactions PR Carlier, ESH Chow, Y Han, J Liu, JE Yazal, YP Pang Journal of medicinal chemistry 42 (20), 4225-4231, 1999 | 179 | 1999 |
| Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease Z Zhang, G Li, SSW Szeto, CM Chong, Q Quan, C Huang, W Cui, B Guo, ... Free radical biology and medicine 84, 331-343, 2015 | 155 | 2015 |
| Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin R Lin, X Chen, W Li, Y Han, P Liu, R Pi Neuroscience letters 440 (3), 344-347, 2008 | 142 | 2008 |
| Novel dimeric acetylcholinesterase inhibitor bis (7)-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors W Li, R Pi, HHN Chan, H Fu, NTK Lee, HW Tsang, Y Pu, DC Chang, C Li, ... Journal of Biological Chemistry 280 (18), 18179-18188, 2005 | 142 | 2005 |
| Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats LM Wang, YF Han, XC Tang European journal of pharmacology 398 (1), 65-72, 2000 | 135 | 2000 |
| Protective effects of huperzine A on β-amyloid25–35 induced oxidative injury in rat pheochromocytoma cells XQ Xiao, R Wang, YF Han, XC Tang Neuroscience letters 286 (3), 155-158, 2000 | 126 | 2000 |
| Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-κB pathway J Chen, Z Sun, M Jin, Y Tu, S Wang, X Yang, Q Chen, X Zhang, Y Han, ... Journal of neuroimmunology 305, 108-114, 2017 | 124 | 2017 |
| Bis (7)‐tacrine attenuates β amyloid‐induced neuronal apoptosis by regulating L‐type calcium channels H Fu, W Li, Y Lao, J Luo, NTK Lee, KKW Kan, HW Tsang, KWK Tsim, ... Journal of neurochemistry 98 (5), 1400-1410, 2006 | 123 | 2006 |
| Acetylcholinesterase complexed with bivalent ligands related to huperzine A: experimental evidence for species-dependent protein− ligand complementarity DM Wong, HM Greenblatt, H Dvir, PR Carlier, YF Han, YP Pang, I Silman, ... Journal of the American Chemical Society 125 (2), 363-373, 2003 | 118 | 2003 |
| Potential roles of PI3K/Akt and Nrf2–Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation H Qi, Y Han, J Rong Neuropharmacology 62 (4), 1659-1670, 2012 | 116 | 2012 |
