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David Cane
David Cane
Professor of Chemistry and Biochemistry, Brown University
Verifierad e-postadress på brown.edu - Startsida
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Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli
BA Pfeifer, SJ Admiraal, H Gramajo, DE Cane, C Khosla
Science 291 (5509), 1790-1792, 2001
9442001
Harnessing the biosynthetic code: combinations, permutations, and mutations
DE Cane, CT Walsh, C Khosla
Science 282 (5386), 63-68, 1998
8741998
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
M Komatsu, T Uchiyama, S Ōmura, DE Cane, H Ikeda
Proceedings of the National Academy of Sciences 107 (6), 2646-2651, 2010
6062010
Enzymic formation of sesquiterpenes
DE Cane
Chemical Reviews 90 (7), 1089-1103, 1990
5831990
Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology
CA Lesburg, G Zhai, DE Cane, DW Christianson
Science 277 (5333), 1820-1824, 1997
5201997
Terpene synthases are widely distributed in bacteria
Y Yamada, T Kuzuyama, M Komatsu, K Shin-Ya, S Omura, DE Cane, ...
Proceedings of the National Academy of Sciences 112 (3), 857-862, 2015
4802015
Tolerance and specificity of polyketide synthases
C Khosla, RS Gokhale, JR Jacobsen, DE Cane
Annual review of biochemistry 68 (1), 219-253, 1999
4691999
Dissecting and exploiting intermodular communication in polyketide synthases
RS Gokhale, SY Tsuji, DE Cane, C Khosla
Science 284 (5413), 482-485, 1999
4351999
The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases
DE Cane, CT Walsh
Chemistry & biology 6 (12), R319-R325, 1999
4171999
Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase
JR Jacobsen, CR Hutchinson, DE Cane, C Khosla
Science 277 (5324), 367-369, 1997
3871997
Structure and mechanism of the 6-deoxyerythronolide B synthase
C Khosla, Y Tang, AY Chen, NA Schnarr, DE Cane
Annu. Rev. Biochem. 76, 195-221, 2007
3572007
The 2.7-Å crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase
Y Tang, CY Kim, II Mathews, DE Cane, C Khosla
Proceedings of the National Academy of Sciences 103 (30), 11124-11129, 2006
3442006
Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade
MJ Rynkiewicz, DE Cane, DW Christianson
Proceedings of the National Academy of Sciences 98 (24), 13543-13548, 2001
3122001
Unified stereochemical model of polyether antibiotic structure and biogenesis
DE Cane, WD Celmer, JW Westley
Journal of the American Chemical Society 105 (11), 3594-3600, 1983
3111983
Sesquiterpene biosynthesis: cyclization mechanisms
DE Cane
Comprehensive natural products chemistry 2, 155-200, 1999
298*1999
Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme
J Jiang, X He, DE Cane
Nature Chemical Biology 3 (11), 711-715, 2007
2912007
Engineered Streptomyces avermitilis Host for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites
M Komatsu, K Komatsu, H Koiwai, Y Yamada, I Kozone, M Izumikawa, ...
ACS synthetic biology 2 (7), 384-396, 2013
2742013
Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel
SC Tsai, LJW Miercke, J Krucinski, R Gokhale, JCH Chen, PG Foster, ...
Proceedings of the National Academy of Sciences 98 (26), 14808-14813, 2001
2672001
Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase
CM Kao, G Luo, L Katz, DE Cane, C Khosla
Journal of the American Chemical Society 117 (35), 9105-9106, 1995
2501995
Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase
RS Gokhale, D Hunziker, DE Cane, C Khosla
Chemistry & biology 6 (2), 117-125, 1999
2191999
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Artiklar 1–20