| Evolution of neoantigen landscape during immune checkpoint blockade in non–small cell lung cancer V Anagnostou, KN Smith, PM Forde, N Niknafs, R Bhattacharya, J White, ... Cancer discovery 7 (3), 264-276, 2017 | 824 | 2017 |
| Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas Y Jiao, TM Pawlik, RA Anders, FM Selaru, MM Streppel, DJ Lucas, ... Nature genetics 45 (12), 1470-1473, 2013 | 688 | 2013 |
| Genomic alterations in head and neck squamous cell carcinoma determined by cancer gene-targeted sequencing CH Chung, VB Guthrie, DL Masica, C Tokheim, H Kang, J Richmon, ... Annals of oncology 26 (6), 1216-1223, 2015 | 191 | 2015 |
| Gemcitabine and cisplatin plus durvalumab with or without tremelimumab in chemotherapy-naive patients with advanced biliary tract cancer: an open-label, single-centre, phase 2 … DY Oh, KH Lee, DW Lee, J Yoon, TY Kim, JH Bang, AR Nam, KS Oh, ... The Lancet Gastroenterology & Hepatology 7 (6), 522-532, 2022 | 181 | 2022 |
| Genomic characterization of malignant progression in neoplastic pancreatic cysts M Noë, N Niknafs, CG Fischer, WM Hackeng, V Beleva Guthrie, ... Nature communications 11 (1), 4085, 2020 | 102 | 2020 |
| Intraductal papillary mucinous neoplasms arise from multiple independent clones, each with distinct mutations CG Fischer, VB Guthrie, AM Braxton, L Zheng, P Wang, Q Song, JF Griffin, ... Gastroenterology 157 (4), 1123-1137. e22, 2019 | 90 | 2019 |
| SubClonal Hierarchy Inference from Somatic Mutations: Automatic Reconstruction of Cancer Evolutionary Trees from Multi-region Next Generation Sequencing N Noushin Niknafs, V Beleva-Guthrie, DQ Naiman, R Karchin PLoS Computational Biology, 2015 | 80 | 2015 |
| Single‐cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions Y Kuboki, CG Fischer, V Beleva Guthrie, W Huang, J Yu, P Chianchiano, ... The Journal of pathology 247 (3), 347-356, 2019 | 61 | 2019 |
| Multiregion whole-exome sequencing of intraductal papillary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions K Fujikura, W Hosoda, M Felsenstein, Q Song, JG Reiter, L Zheng, ... Gut 70 (5), 928-939, 2021 | 56 | 2021 |
| Evolution of neoantigen landscape during immune checkpoint blockade in non-small cell lung cancer. Cancer Discov. 2017; 7 (3): 264–276. doi: 10.1158/2159-8290 V Anagnostou, KN Smith, PM Forde, N Niknafs, R Bhattacharya, J White, ... Chin Med J 129 (4), 448-55, 2016 | 45 | 2016 |
| Reports from CAGI: the critical assessment of genome interpretation RA Hoskins, S Repo, D Barsky, G Andreoletti, J Moult, SE Brenner Human mutation 38 (9), 1039, 2017 | 43 | 2017 |
| Network models of TEM β-lactamase mutations coevolving under antibiotic selection show modular structure and anticipate evolutionary trajectories VB Guthrie, J Allen, M Camps, R Karchin PLoS computational biology 7 (9), e1002184, 2011 | 41 | 2011 |
| Langmuir monolayers of bent-core molecules L Zou, J Wang, VJ Beleva, EE Kooijman, SV Primak, J Risse, W Weissflog, ... Langmuir 20 (7), 2772-2780, 2004 | 41 | 2004 |
| Evaluation of machine learning methods to predict peptide binding to MHC Class I proteins R Bhattacharya, A Sivakumar, C Tokheim, VB Guthrie, V Anagnostou, ... BioRxiv, 154757, 2017 | 39 | 2017 |
| Matching phenotypes to whole genomes: Lessons learned from four iterations of the personal genome project community challenges B Cai, B Li, N Kiga, J Thusberg, T Bergquist, YC Chen, N Niknafs, ... Human mutation 38 (9), 1266-1276, 2017 | 18 | 2017 |
| A probabilistic model to predict clinical phenotypic traits from genome sequencing YC Chen, C Douville, C Wang, N Niknafs, G Yeo, V Beleva-Guthrie, ... PLoS computational biology 10 (9), e1003825, 2014 | 17 | 2014 |
| Evolution of neoantigen landscape during immune checkpoint blockade in non-small cell lung cancer. Cancer Discov. 2017; 7: 264–76 V Anagnostou, KN Smith, PM Forde, N Niknafs, R Bhattacharya, J White, ... | 12 | |
| Validation of a Circulating Tumor DNA-Based Next-Generation Sequencing Assay in a Cohort of Patients with Solid tumors: A Proposed Solution for Decentralized … W Al Zoughbi, J Fox, S Beg, E Papp, E Hissong, K Ohara, L Keefer, ... The oncologist 26 (11), e1971-e1981, 2021 | 11 | 2021 |
| Network Analysis of Protein Adaptation: modeling the functional impact of multiple mutations V Beleva Guthrie, M David L, A Fraser, Federico, Joseph, Y Fan, ... Molecular Biology and Evolution, msy036, 2018 | 10 | 2018 |
| 68O Impact of mutation status on efficacy outcomes in TOPAZ-1: A phase III study of durvalumab (D) or placebo (PBO) plus gemcitabine and cisplatin (+ GC) in advanced biliary … JW Valle, S Qin, L Antonuzzo, D Tougeron, CK Lee, BJ Tan, M Ikeda, ... Annals of Oncology 33, S1457, 2022 | 8 | 2022 |
Rachel KarchinProfessor of Biomedical Engineering, Oncology and Computer Science, Johns Hopkins UniversityVerified email at jhu.edu
