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Caglar Cekic, Ph.D.
Caglar Cekic, Ph.D.
Novartis Institutes for BioMedical Research
Verifierad e-postadress på novartis.com
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The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4
V Mata-Haro, C Cekic, M Martin, PM Chilton, CR Casella, TC Mitchell
Science 316 (5831), 1628-1632, 2007
10172007
Purinergic regulation of the immune system
C Cekic, J Linden
Nature Reviews Immunology 16 (3), 177-192, 2016
7632016
Patrolling monocytes control tumor metastasis to the lung
RN Hanna, C Cekic, D Sag, R Tacke, GD Thomas, H Nowyhed, E Herrley, ...
Science 350 (6263), 985-990, 2015
4682015
Myeloid Expression of Adenosine A2A Receptor Suppresses T and NK Cell Responses in the Solid Tumor Microenvironment
C Cekic, YJ Day, D Sag, J Linden
Cancer research 74 (24), 7250-7259, 2014
2902014
Adenosine A2B Receptor Blockade Slows Growth of Bladder and Breast Tumors
C Cekic, D Sag, Y Li, D Theodorescu, RM Strieter, J Linden
The Journal of Immunology, 2012
2252012
Regulation of lymphocyte function by adenosine
J Linden, C Cekic
Arteriosclerosis, thrombosis, and vascular biology 32 (9), 2097-2103, 2012
1772012
The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity
D Sag, C Cekic, R Wu, J Linden, CC Hedrick
Nature communications 6 (1), 6354, 2015
1762015
Adenosine A2A Receptors Intrinsically Regulate CD8+ T Cells in the Tumor Microenvironment
C Cekic, J Linden
Cancer research 74 (24), 7239-7249, 2014
1702014
Extracellular adenosine regulates naive T cell development and peripheral maintenance
C Cekic, D Sag, YJ Day, J Linden
Journal of Experimental Medicine 210 (12), 2693-2706, 2013
1222013
Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A
C Cekic, CR Casella, CA Eaves, A Matsuzawa, H Ichijo, TC Mitchell
Journal of Biological Chemistry 284 (46), 31982-31991, 2009
1142009
IFN-β production by TLR4-stimulated innate immune cells is negatively regulated by GSK3-β
H Wang, CA Garcia, K Rehani, C Cekic, P Alard, DF Kinane, T Mitchell, ...
The Journal of Immunology 181 (10), 6797-6802, 2008
952008
The Expression of Adenosine A2B Receptor on Antigen-Presenting Cells Suppresses CD8+ T-cell Responses and Promotes Tumor Growth
S Chen, I Akdemir, J Fan, J Linden, B Zhang, C Cekic
Cancer immunology research 8 (8), 1064-1074, 2020
512020
MyD88-dependent SHIP1 regulates proinflammatory signaling pathways in dendritic cells after monophosphoryl lipid A stimulation of TLR4
C Cekic, CR Casella, D Sag, F Antignano, J Kolb, J Suttles, MR Hughes, ...
The Journal of Immunology 186 (7), 3858-3865, 2011
472011
Reactivation of cAMP pathway by PDE4D inhibition represents a novel druggable axis for overcoming tamoxifen resistance in ER-positive breast cancer
RR Mishra, N Belder, SA Ansari, M Kayhan, H Bal, U Raza, PG Ersan, ...
Clinical Cancer Research 24 (8), 1987-2001, 2018
462018
Adenosine receptor signaling targets both PKA and Epac pathways to polarize dendritic cells to a suppressive phenotype
M Kayhan, A Koyas, I Akdemir, AC Savas, C Cekic
The Journal of Immunology 203 (12), 3247-3255, 2019
302019
Targeting adenosine with adenosine deaminase 2 to inhibit growth of solid tumors
L Wang, LM Londono, J Cowell, O Saatci, M Aras, PG Ersan, S Serra, ...
Cancer Research 81 (12), 3319-3332, 2021
192021
Interleukin-7 protects CD8+ T cells from adenosine-mediated immunosuppression
A Koyas, S Tucer, M Kayhan, AC Savas, I Akdemir, C Cekic
Science Signaling 14 (674), eabb1269, 2021
152021
Ecto-5′-Nucleotidase (CD73) Regulates the Survival of CD8+ T Cells
MV Rosemblatt, B Parra-Tello, P Briceño, E Rivas-Yáñez, S Tucer, ...
Frontiers in Cell and Developmental Biology 9, 647058, 2021
72021
Modulation of myeloid cells by adenosine signaling
C Cekic
Current Opinion in Pharmacology 53, 134-145, 2020
42020
Methods and compositions for treating cancer
TVK George A. Gaitanaris, Marc A. Gavin, Robert H. LEMUS, Caglar CEKIC ...
WO Patent WO2023039578A1, 2023
2023
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Artiklar 1–20