| Neuroinflammation in Alzheimer's disease MT Heneka, MJ Carson, J El Khoury, GE Landreth, F Brosseron, ... The Lancet Neurology 14 (4), 388-405, 2015 | 5280 | 2015 |
| A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window J Yrjänheikki, T Tikka, R Keinänen, G Goldsteins, PH Chan, J Koistinaho Proceedings of the National Academy of Sciences 96 (23), 13496-13500, 1999 | 1258 | 1999 |
| Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia J Yrjänheikki, R Keinänen, M Pellikka, T Hökfelt, J Koistinaho Proceedings of the National Academy of Sciences 95 (26), 15769-15774, 1998 | 1230 | 1998 |
| Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia T Tikka, BL Fiebich, G Goldsteins, R Keinänen, J Koistinaho Journal of Neuroscience 21 (8), 2580-2588, 2001 | 1113 | 2001 |
| Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia TM Tikka, JE Koistinaho The Journal of Immunology 166 (12), 7527-7533, 2001 | 706 | 2001 |
| Nuclear factor-κB contributes to infarction after permanent focal ischemia A Nurmi, PJ Lindsberg, M Koistinaho, W Zhang, E Juettler, ... Stroke 35 (4), 987-991, 2004 | 415 | 2004 |
| Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to β-amyloid deposition in APP/PS1 double transgenic Alzheimer mice TM Malm, M Koistinaho, M Pärepalo, T Vatanen, A Ooka, S Karlsson, ... Neurobiology of disease 18 (1), 134-142, 2005 | 363 | 2005 |
| Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-d-aspartic acid-receptors and phospholipase A2 S Miettinen, FR Fusco, J Yrjänheikki, R Keinänen, T Hirvonen, ... Proceedings of the National Academy of Sciences 94 (12), 6500-6505, 1997 | 349 | 1997 |
| Astrocytes protect neurons from nitric oxide toxicity by a glutathione‐dependent mechanism Y Chen, NE Vartiainen, W Ying, PH Chan, J Koistinaho, RA Swanson Journal of neurochemistry 77 (6), 1601-1610, 2001 | 345 | 2001 |
| Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease K Kanninen, R Heikkinen, T Malm, T Rolova, S Kuhmonen, H Leinonen, ... Proceedings of the National Academy of Sciences 106 (38), 16505-16510, 2009 | 318 | 2009 |
| Role of p38 and p44/42 mitogen‐activated protein kinases in microglia M Koistinaho, J Koistinaho Glia 40 (2), 175-183, 2002 | 317 | 2002 |
| Improving outcome after stroke: overcoming the translational roadblock M Endres, B Engelhardt, J Koistinaho, O Lindvall, S Meairs, JP Mohr, ... Cerebrovascular diseases 25 (3), 268-278, 2008 | 297 | 2008 |
| Nuclear factor erythroid 2-related factor 2 protects against beta amyloid K Kanninen, TM Malm, HK Jyrkkänen, G Goldsteins, V Keksa-Goldsteine, ... Molecular and Cellular Neuroscience 39 (3), 302-313, 2008 | 290 | 2008 |
| PSEN1 mutant iPSC-derived model reveals severe astrocyte pathology in Alzheimer's disease M Oksanen, AJ Petersen, N Naumenko, K Puttonen, Š Lehtonen, ... Stem cell reports 9 (6), 1885-1897, 2017 | 283 | 2017 |
| Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma MO Hiltunen, L Alhonen, J Koistinaho, S Myöhänen, M Pääkkönen, ... International journal of cancer 70 (6), 644-648, 1997 | 259 | 1997 |
| Induction of 70-kDa heat shock protein and hsp70 mRNA following transient focal cerebral ischemia in the rat H Kinouchi, FR Sharp, MP Hill, J Koistinaho, SM Sagar, PH Chan Journal of Cerebral Blood Flow & Metabolism 13 (1), 105-115, 1993 | 250 | 1993 |
| Hypoxia induces microRNA miR-210 in vitro and in vivo: Ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210 K Pulkkinen, T Malm, M Turunen, J Koistinaho, S Ylä-Herttuala FEBS letters 582 (16), 2397-2401, 2008 | 247 | 2008 |
| Age‐related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild‐type mice R Minkeviciene, J Ihalainen, T Malm, O Matilainen, V Keksa‐Goldsteine, ... Journal of neurochemistry 105 (3), 584-594, 2008 | 224 | 2008 |
| Exosomes as new diagnostic tools in CNS diseases KM Kanninen, N Bister, J Koistinaho, T Malm Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1862 (3), 403-410, 2016 | 216 | 2016 |
| Specific spatial learning deficits become severe with age in β-amyloid precursor protein transgenic mice that harbor diffuse β-amyloid deposits but do not form plaques M Koistinaho, M Ort, JM Cimadevilla, R Vondrous, B Cordell, J Koistinaho, ... Proceedings of the National Academy of Sciences 98 (25), 14675-14680, 2001 | 215 | 2001 |
