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Gadhe Laxmikant
Gadhe Laxmikant
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Year
α-Synuclein aggregation nucleates through liquid–liquid phase separation
S Ray, N Singh, R Kumar, K Patel, S Pandey, D Datta, J Mahato, ...
Nature chemistry 12 (8), 705-716, 2020
4942020
Glycosaminoglycans have variable effects on α-synuclein aggregation and differentially affect the activities of the resulting amyloid fibrils
S Mehra, D Ghosh, R Kumar, M Mondal, LG Gadhe, S Das, A Anoop, ...
Journal of Biological Chemistry 293 (34), 12975-12991, 2018
572018
Liquid-liquid phase separation of α-synuclein: a new mechanistic insight for α-synuclein aggregation associated with Parkinson's disease pathogenesis
S Mukherjee, A Sakunthala, L Gadhe, M Poudyal, AS Sawner, P Kadu, ...
Journal of Molecular Biology 435 (1), 167713, 2023
532023
Comparison of kinetics, toxicity, oligomer formation, and membrane binding capacity of α-synuclein familial mutations at the A53 site, including the newly discovered A53V mutation
GM Mohite, R Kumar, R Panigrahi, A Navalkar, N Singh, D Datta, S Mehra, ...
Biochemistry 57 (35), 5183-5187, 2018
492018
Structural and functional insights into α-synuclein fibril polymorphism
S Mehra, L Gadhe, R Bera, AS Sawner, SK Maji
Biomolecules 11 (10), 1419, 2021
482021
Intermediates of α-synuclein aggregation: Implications in Parkinson's disease pathogenesis
L Gadhe, A Sakunthala, S Mukherjee, N Gahlot, R Bera, AS Sawner, ...
Biophysical Chemistry 281, 106736, 2022
292022
The familial α-synuclein A53E mutation enhances cell death in response to environmental toxins due to a larger population of oligomers
GM Mohite, A Navalkar, R Kumar, S Mehra, S Das, LG Gadhe, D Ghosh, ...
Biochemistry 57 (33), 5014-5028, 2018
242018
Liquid-liquid phase separation and liquid-to-solid transition mediate α-synuclein amyloid fibril containing hydrogel formation
S Ray, N Singh, S Pandey, R Kumar, L Gadhe, D Datta, K Patel, J Mahato, ...
bioRxiv, 619858, 2019
232019
α-Synuclein aggregation intermediates form fibril polymorphs with distinct prion-like properties
S Mehra, S Ahlawat, H Kumar, D Datta, A Navalkar, N Singh, K Patel, ...
Journal of Molecular Biology 434 (19), 167761, 2022
172022
Liquid condensate is a common state of proteins and polypeptides at the regime of high intermolecular interactions
M Poudyal, K Patel, AS Sawner, L Gadhe, P Kadu, D Datta, S Mukherjee, ...
bioRxiv, 2021.12. 31.474648, 2022
172022
Intermolecular interactions underlie protein/peptide phase separation irrespective of sequence and structure at crowded milieu
M Poudyal, K Patel, L Gadhe, AS Sawner, P Kadu, D Datta, S Mukherjee, ...
Nature Communications 14 (1), 6199, 2023
132023
Co-aggregation and secondary nucleation in the life cycle of human prolactin/galanin functional amyloids
D Chatterjee, RS Jacob, S Ray, A Navalkar, N Singh, S Sengupta, ...
Elife 11, e73835, 2022
132022
Biocompatible fluorescent probe for selective detection of amyloid fibrils
A Das, T Dutta, L Gadhe, AL Koner, I Saraogi
Analytical Chemistry 92 (15), 10336-10341, 2020
92020
Direct demonstration of seed size-dependent α-synuclein amyloid amplification
A Sakunthala, D Datta, A Navalkar, L Gadhe, P Kadu, K Patel, S Mehra, ...
The Journal of Physical Chemistry Letters 13 (28), 6427-6438, 2022
82022
Benzimidazole‐based fluorophores for the detection of amyloid fibrils with higher sensitivity than Thioflavin‐T
N Pravin, R Kumar, S Tripathi, P Kumar, GM Mohite, A Navalkar, ...
Journal of Neurochemistry 156 (6), 1003-1019, 2021
72021
Phase separation and other forms of α-Synuclein self-assemblies
M Poudyal, A Sakunthala, S Mukherjee, L Gadhe, SK Maji
Essays in Biochemistry 66 (7), 987-1000, 2022
52022
p53 amyloid pathology is correlated with higher cancer grade irrespective of the mutant or wild-type form
S Sengupta, N Singh, A Paul, D Datta, D Chatterjee, S Mukherjee, ...
Journal of cell science 136 (17), jcs261017, 2023
42023
Charge and hydrophobicity of amyloidogenic protein/peptide templates regulate the growth and morphology of gold nanoparticles
P Kadu, L Gadhe, A Navalkar, K Patel, R Kumar, M Sastry, SK Maji
Nanoscale 14 (40), 15021-15033, 2022
22022
Sensitized Emission Imaging Allows Nanoscale Surface Polarity Mapping of α-Synuclein Amyloid Fibrils
J Mahato, R Mukherjee, A Bose, S Mehra, L Gadhe, SK Maji, ...
ACS Chemical Neuroscience, 2023
2023
Nucleo-cytoplasmic environment modulates spatio-temporal p53 phase separation
D Datta, A Navalkar, A Sakunthala, A Paul, K Patel, S Masurkar, L Gadhe, ...
bioRxiv, 2023.10. 16.562512, 2023
2023
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