Elisa Greggio
Elisa Greggio
Associate Professor of Physiology
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Cited by
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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
E Greggio, S Jain, A Kingsbury, R Bandopadhyay, P Lewis, A Kaganovich, ...
Neurobiology of disease 23 (2), 329-341, 2006
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
A Beilina, IN Rudenko, A Kaganovich, L Civiero, H Chau, SK Kalia, ...
Proceedings of the National Academy of Sciences 111 (7), 2626-2631, 2014
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation
E Greggio, I Zambrano, A Kaganovich, A Beilina, JM Taymans, V DaniŽls, ...
Journal of Biological Chemistry 283 (24), 16906-16914, 2008
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
PA Lewis, E Greggio, A Beilina, S Jain, A Baker, MR Cookson
Biochemical and biophysical research communications 357 (3), 668-671, 2007
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions
E Greggio, MR Cookson
ASN neuro 1 (1), AN20090007, 2009
Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1
J Blackinton, M Lakshminarasimhan, KJ Thomas, R Ahmad, E Greggio, ...
Journal of Biological Chemistry 284 (10), 6476-6485, 2009
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
J Deng, PA Lewis, E Greggio, E Sluch, A Beilina, MR Cookson
Proceedings of the National Academy of Sciences 105 (5), 1499-1504, 2008
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2
L Wang, C Xie, E Greggio, L Parisiadou, H Shim, L Sun, J Chandran, ...
Journal of Neuroscience 28 (13), 3384-3391, 2008
LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?
I Russo, L Bubacco, E Greggio
Journal of neuroinflammation 11, 1-9, 2014
The Parkinson’s disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites
E Greggio, JM Taymans, EY Zhen, J Ryder, R Vancraenenbroeck, ...
Biochemical and biophysical research communications 389 (3), 449-454, 2009
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2
A Biosa, A Trancikova, L Civiero, L Glauser, L Bubacco, E Greggio, ...
Human molecular genetics 22 (6), 1140-1156, 2013
Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant
V DaniŽls, R Vancraenenbroeck, BMH Law, E Greggio, E Lobbestael, ...
Journal of neurochemistry 116 (2), 304-315, 2011
Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease
E Greggio, E Bergantino, D Carter, R Ahmad, GE Costin, VJ Hearing, ...
Journal of neurochemistry 93 (1), 246-256, 2005
DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function
N Plotegher, G Berti, E Ferrari, I Tessari, M Zanetti, L Lunelli, E Greggio, ...
Scientific reports 7 (1), 40699, 2017
Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells
I Russo, G Berti, N Plotegher, G Bernardo, R Filograna, L Bubacco, ...
Journal of neuroinflammation 12, 1-13, 2015
MKK6 binds and regulates expression of Parkinson’s disease‐related protein LRRK2
CH Hsu, D Chan, E Greggio, S Saha, MD Guillily, A Ferree, K Raghavan, ...
Journal of neurochemistry 112 (6), 1593-1604, 2010
Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers
L Civiero, R Vancraenenbroeck, E Belluzzi, A Beilina, E Lobbestael, ...
Public Library of Science 7 (8), e43472, 2012
Exosomes-associated neurodegeneration and progression of Parkinson’s disease
I Russo, L Bubacco, E Greggio
American journal of neurodegenerative disease 1 (3), 217, 2012
The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation
A Kumar, E Greggio, A Beilina, A Kaganovich, D Chan, JM Taymans, ...
PloS one 5 (1), e8730, 2010
LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex
MD Cirnaru, A Marte, E Belluzzi, I Russo, M Gabrielli, F Longo, L Arcuri, ...
Frontiers in molecular neuroscience 7, 49, 2014
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