ilgen mender
ilgen mender
Postdoctoral Researcher of Cell Biology, UTSouthwestern Medical Center
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Regulation of the Human Telomerase Gene TERT by Telomere Position Effect—Over Long Distances (TPE-OLD): Implications for Aging and Cancer
W Kim, AT Ludlow, J Min, JD Robin, G Stadler, I Mender, TP Lai, N Zhang, ...
PLoS biology 14 (12), e2000016, 2016
Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2′-deoxyguanosine
I Mender, S Gryaznov, ZG Dikmen, WE Wright, JW Shay
Cancer discovery 5 (1), 82-95, 2015
A method for measuring the distribution of the shortest telomeres in cells and tissues
TP Lai, N Zhang, J Noh, I Mender, E Tedone, E Huang, WE Wright, ...
Nature communications 8 (1), 1-14, 2017
Telomerase repeated amplification protocol (TRAP)
I Mender, JW Shay
Bio-protocol 5 (22), 2015
NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer
AT Ludlow, MS Wong, JD Robin, K Batten, L Yuan, TP Lai, N Dahlson, ...
Nature communications 9 (1), 1-15, 2018
Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma
P Reyes-Uribe, MP Adrianzen-Ruesta, Z Deng, I Echevarria-Vargas, ...
Oncogene 37 (30), 4058-4072, 2018
Imetelstat (a telomerase antagonist) exerts off‑target effects on the cytoskeleton
I Mender, S Senturk, N Ozgunes, K Akcali, D Kletsas, S Gryaznov, A Can, ...
International journal of oncology 42 (5), 1709-1715, 2013
Telomere restriction fragment (TRF) analysis
I Mender, JW Shay
Bio-protocol 5 (22), 2015
Induced telomere damage to treat telomerase expressing therapy-resistant pediatric brain tumors
S Sengupta, M Sobo, K Lee, SS Kumar, AR White, I Mender, C Fuller, ...
Molecular cancer therapeutics 17 (7), 1504-1514, 2018
Telomerase-mediated strategy for overcoming non–small cell lung cancer targeted therapy and chemotherapy resistance
I Mender, R LaRanger, K Luitel, M Peyton, L Girard, TP Lai, K Batten, ...
Neoplasia 20 (8), 826-837, 2018
Telomere dysfunction induced foci (TIF) analysis
I Mender, JW Shay
Bio-protocol 5 (22), 2015
A novel telomerase substrate precursor rapidly induces telomere dysfunction in telomerase positive cancer cells but not telomerase silent normal cells
I Mender, S Gryaznov, JW Shay
Oncoscience 2 (8), 693, 2015
Induction of telomere dysfunction prolongs disease control of therapy-resistant melanoma
G Zhang, LW Wu, I Mender, M Barzily-Rokni, MR Hammond, O Ope, ...
Clinical Cancer Research 24 (19), 4771-4784, 2018
A primary melanoma and its asynchronous metastasis highlight the role of BRAF, CDKN2A, and TERT
GA Hosler, T Davoli, I Mender, B Litzner, J Choi, P Kapur, JW Shay, ...
Journal of cutaneous pathology 42 (2), 108-117, 2015
Telomere stress potentiates STING-dependent anti-tumor immunity
I Mender, A Zhang, Z Ren, C Han, Y Deng, S Siteni, H Li, J Zhu, A Vemula, ...
Cancer Cell 38 (3), 400-411. e6, 2020
Human lung epithelial cells divide> 200 population doublings without engaging a telomere maintenance mechanism
JR Peters-Hall, J Min, E Tedone, S Sho, S Siteni, I Mender, JW Shay
BioRxiv, 474270, 2018
Proliferation of adult human bronchial epithelial cells without a telomere maintenance mechanism for over 200 population doublings
JR Peters‐Hall, J Min, E Tedone, S Sho, S Siteni, I Mender, JW Shay
The FASEB Journal 34 (1), 386-398, 2020
SLC43A3 Is a Biomarker of Sensitivity to the Telomeric DNA Damage Mediator 6-Thio-2′-Deoxyguanosine
I Mender, K Batten, M Peyton, A Vemula, C Cornelius, L Girard, B Gao, ...
Cancer research 80 (5), 929-936, 2020
How can I protect my telomeres and slow aging?
ZG Dikmen, I Mender
Turkish Journal of Biochemistry 42 (6), 587-590, 2017
Treatment of drug resistant proliferative diseases with telomerase mediated telomere altering compounds
J Shay, I Mender, K Batten, C Lander
US Patent App. 15/467,862, 2018
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