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Lena Afeyan
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Transcription factors activate genes through the phase-separation capacity of their activation domains
A Boija, IA Klein, BR Sabari, A Dall’Agnese, EL Coffey, AV Zamudio, ...
Cell 175 (7), 1842-1855. e16, 2018
13402018
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates
YE Guo, JC Manteiga, JE Henninger, BR Sabari, A Dall’Agnese, ...
Nature 572 (7770), 543-548, 2019
5042019
Partitioning of cancer therapeutics in nuclear condensates
IA Klein, A Boija, LK Afeyan, SW Hawken, M Fan, A Dall'Agnese, O Oksuz, ...
Science 368 (6497), 1386-1392, 2020
3162020
Mediator condensates localize signaling factors to key cell identity genes
AV Zamudio, A Dall’Agnese, JE Henninger, JC Manteiga, LK Afeyan, ...
Molecular cell 76 (5), 753-766. e6, 2019
2032019
MeCP2 links heterochromatin condensates and neurodevelopmental disease
CH Li, EL Coffey, A Dall’Agnese, NM Hannett, X Tang, JE Henninger, ...
Nature 586 (7829), 440-444, 2020
1342020
Predicting master transcription factors from pan-cancer expression data
J Reddy, MAS Fonseca, RI Corona, R Nameki, F Segato Dezem, IA Klein, ...
Science advances 7 (48), eabf6123, 2021
432021
Genetic variation associated with condensate dysregulation in disease
SF Banani, LK Afeyan, SW Hawken, JE Henninger, A Dall’Agnese, ...
Developmental cell 57 (14), 1776-1788. e8, 2022
392022
High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases
JL Bessen, LK Afeyan, V Dančík, LW Koblan, DB Thompson, C Leichner, ...
Nature communications 10 (1), 1937, 2019
282019
The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17
D Chaves-Moreira, MA Mitchell, C Arruza, P Rawat, S Sidoli, R Nameki, ...
Science signaling 15 (728), eabm2496, 2022
232022
Transcription factors activate genes through the phase-separation capacity of their activation domains
IA Klein, BR Sabari, A Dall’Agnese, EL Coffey, AV Zamudio, JC Manteiga, ...
Elsevier BV, 2018
92018
Partitioning of cancer therapeutics in nuclear condensates.
I Klein, A Boija, L Afeyan, S Hawken, M Fan, D Taatjes, A Chakraborty, ...
Journal of Clinical Oncology 39 (15_suppl), 3131-3131, 2021
22021
Researcher Page
IA Klein, A Boija, LK Afeyan
Science 368 (6497), 1386-1392, 2020
22020
Methods and assays for modulating gene transcription by modulating condensates
RA Young, PA Sharp, AK Chakraborty, A Dall'Agnese, K Shrinivas, ...
US Patent App. 17/040,967, 2022
12022
Transcriptional and splicing condensates
YE Guo, JC Manteiga, JE Henninger, BR Sabari, AD Agnese, K Shrinivas, ...
12019
Chemical codes promote selective compartmentalization of proteins
H Kilgore, I Chinn, P Mikhael, I Mitnikov, C Van Dongen, G Zylberberg, ...
bioRxiv, 2024.04. 15.589616, 2024
2024
Insights from biomolecular condensates into disease and drug development
LK Afeyan
Massachusetts Institute of Technology, 2022
2022
Abstract GS3-10: Partitioning of cancer therapeutics in nuclear condensates
I Klein, A Boija, L Afeyan, SW Hawken, M Fan, A Dall'Agnese, O Oksuz, ...
Cancer Research 81 (4_Supplement), GS3-10-GS3-10, 2021
2021
Systematic approaches to predict oncogenic transcriptional regulatory circuitries identify important nodes in high-grade serous ovarian cancer
BJ Abraham, J Reddy, MA Fonseca, IA Klein, LK Afeyan, RI Corona, ...
Cancer Research 79 (13_Supplement), 2615-2615, 2019
2019
Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes
A Zamudio Montes de Oca, A Dall’Agnese, JE Henninger, JC Manteiga, ...
Elsevier BV, 2019
2019
Genetic Variation Associated with Condensate Dysregulation in
SF Banani, LK Afeyan, SW Hawken, JE Henninger, A Dall’Agnese, ...
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Artiklar 1–20