Följ
Celeste M Karch
Celeste M Karch
Professor of Psychiatry, Washington University in St Louis
Verifierad e-postadress på wustl.edu - Startsida
Titel
Citeras av
Citeras av
År
Alzheimer’s disease risk genes and mechanisms of disease pathogenesis
CM Karch, AM Goate
Biological psychiatry 77 (1), 43-51, 2015
13732015
Tau kinetics in neurons and the human central nervous system
C Sato, NR Barthélemy, KG Mawuenyega, BW Patterson, BA Gordon, ...
Neuron 97 (6), 1284-1298. e7, 2018
5242018
Alzheimer’s disease genetics: from the bench to the clinic
CM Karch, C Cruchaga, AM Goate
Neuron 83 (1), 11-26, 2014
5212014
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease
C Cruchaga, CM Karch, SC Jin, BA Benitez, Y Cai, R Guerreiro, O Harari, ...
Nature 505 (7484), 550-554, 2014
5202014
A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease
NR Barthélemy, Y Li, N Joseph-Mathurin, BA Gordon, J Hassenstab, ...
Nature medicine 26 (3), 398-407, 2020
4132020
Genetic assessment of age-associated Alzheimer disease risk: development and validation of a polygenic hazard score
RS Desikan, CC Fan, Y Wang, AJ Schork, HJ Cabral, LA Cupples, ...
PLoS medicine 14 (3), e1002258, 2017
3822017
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer’s disease
C Cruchaga, JSK Kauwe, O Harari, SC Jin, Y Cai, CM Karch, BA Benitez, ...
Neuron 78 (2), 256-268, 2013
3762013
Expression of novel Alzheimer’s disease risk genes in control and Alzheimer’s disease brains
CM Karch, AT Jeng, P Nowotny, J Cady, C Cruchaga, AM Goate
PloS one 7 (11), e50976, 2012
3672012
An efficient platform for astrocyte differentiation from human induced pluripotent stem cells
TCW Julia, M Wang, AA Pimenova, KR Bowles, BJ Hartley, E Lacin, ...
Stem cell reports 9 (2), 600-614, 2017
3572017
Coding variants in TREM2 increase risk for Alzheimer's disease
SC Jin, BA Benitez, CM Karch, B Cooper, T Skorupa, D Carrell, JB Norton, ...
Human molecular genetics 23 (21), 5838-5846, 2014
2922014
Scalable production of iPSC-derived human neurons to identify tau-lowering compounds by high-content screening
C Wang, ME Ward, R Chen, K Liu, TE Tracy, X Chen, M Xie, PD Sohn, ...
Stem cell reports 9 (4), 1221-1233, 2017
2602017
An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations
U Dube, JL Del-Aguila, Z Li, JP Budde, S Jiang, S Hsu, L Ibanez, ...
Nature neuroscience 22 (11), 1903-1912, 2019
2572019
Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS
CM Karch, M Prudencio, DD Winkler, PJ Hart, DR Borchelt
Proceedings of the National Academy of Sciences 106 (19), 7774-7779, 2009
2282009
The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk
Y Deming, F Filipello, F Cignarella, C Cantoni, S Hsu, R Mikesell, Z Li, ...
Science translational medicine 11 (505), eaau2291, 2019
2052019
Extracellular tau levels are influenced by variability in tau that is associated with tauopathies
CM Karch, AT Jeng, AM Goate
Journal of Biological Chemistry, 2012
1952012
Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy
S Da Mesquita, Z Papadopoulos, T Dykstra, L Brase, FG Farias, M Wall, ...
Nature 593 (7858), 255-260, 2021
1942021
Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
M Suárez-Calvet, E Morenas-Rodríguez, G Kleinberger, K Schlepckow, ...
Molecular neurodegeneration 14, 1-14, 2019
1912019
Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
DL Kober, JM Alexander-Brett, CM Karch, C Cruchaga, M Colonna, ...
elife 5, e20391, 2016
1832016
Association between genetic traits for immune-mediated diseases and Alzheimer disease
JS Yokoyama, Y Wang, AJ Schork, WK Thompson, CM Karch, ...
JAMA neurology 73 (6), 691-697, 2016
1572016
Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: αB-crystallin modulates aggregation
J Wang, G Xu, H Li, V Gonzales, D Fromholt, C Karch, NG Copeland, ...
Human molecular genetics 14 (16), 2335-2347, 2005
1512005
Systemet kan inte utföra åtgärden just nu. Försök igen senare.
Artiklar 1–20