| Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis V Makarov, G Manina, K Mikusova, U Möllmann, O Ryabova, ... Science 324 (5928), 801-804, 2009 | 840 | 2009 |
| Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis K Pethe, P Bifani, J Jang, S Kang, S Park, S Ahn, J Jiricek, J Jung, ... Nature medicine 19 (9), 1157-1160, 2013 | 605 | 2013 |
| High content screening identifies decaprenyl-phosphoribose 2′ epimerase as a target for intracellular antimycobacterial inhibitors T Christophe, M Jackson, HK Jeon, D Fenistein, M Contreras-Dominguez, ... PLoS pathogens 5 (10), e1000645, 2009 | 386 | 2009 |
| The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed … T Christophe, A Karlsson, C Dugave, MJ Rabiet, F Boulay, C Dahlgren Journal of Biological Chemistry 276 (24), 21585-21593, 2001 | 252 | 2001 |
| Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases L Van Rompaey, R Galien, EM van der Aar, P Clement-Lacroix, L Nelles, ... The Journal of Immunology 191 (7), 3568-3577, 2013 | 214 | 2013 |
| High Content Phenotypic Cell-Based Visual Screen Identifies Mycobacterium tuberculosis Acyltrehalose-Containing Glycolipids Involved in Phagosome Remodeling P Brodin, Y Poquet, F Levillain, I Peguillet, G Larrouy-Maumus, M Gilleron, ... PLoS pathogens 6 (9), e1001100, 2010 | 213 | 2010 |
| A proinflammatory peptide from Helicobacter pylori activates monocytes to induce lymphocyte dysfunction and apoptosis Å Betten, J Bylund, T Cristophe, F Boulay, A Romero, K Hellstrand, ... The Journal of clinical investigation 108 (8), 1221-1228, 2001 | 202 | 2001 |
| Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways E Marion, OR Song, T Christophe, J Babonneau, D Fenistein, J Eyer, ... Cell 157 (7), 1565-1576, 2014 | 198 | 2014 |
| Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds JL Siqueira-Neto, OR Song, H Oh, JH Sohn, G Yang, J Nam, J Jang, ... PLoS neglected tropical diseases 4 (5), e675, 2010 | 169 | 2010 |
| The synthetic chemoattractant Trp-Lys-Tyr-Met-Val-DMet activates neutrophils preferentially through the lipoxin A4 receptor C Dahlgren, T Christophe, F Boulay, PN Madianos, MJ Rabiet, A Karlsson Blood, The Journal of the American Society of Hematology 95 (5), 1810-1818, 2000 | 148 | 2000 |
| The synthetic chemoattractant Trp-Lys-Tyr-Met-Val-DMet activates neutrophils preferentially through the lipoxin A4 receptor C Dahlgren, T Christophe, F Boulay, PN Madianos, MJ Rabiet, A Karlsson Blood, The Journal of the American Society of Hematology 95 (5), 1810-1818, 2000 | 148 | 2000 |
| Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5 … N Desroy, C Housseman, X Bock, A Joncour, N Bienvenu, L Cherel, ... Journal of medicinal chemistry 60 (9), 3580-3590, 2017 | 130 | 2017 |
| Triazolopyridines as selective JAK1 inhibitors: from hit identification to GLPG0634 CJ Menet, SR Fletcher, G Van Lommen, R Geney, J Blanc, K Smits, ... Journal of Medicinal Chemistry 57 (22), 9323-9342, 2014 | 120 | 2014 |
| Ethionamide boosters: synthesis, biological activity, and structure− activity relationships of a series of 1, 2, 4-oxadiazole EthR inhibitors M Flipo, M Desroses, N Lecat-Guillet, B Dirié, X Carette, F Leroux, ... Journal of Medicinal Chemistry 54 (8), 2994-3010, 2011 | 112 | 2011 |
| Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a β-arrestin, dynamin, and clathrin-dependent pathway L Braun, T Christophe, F Boulay Journal of Biological Chemistry 278 (6), 4277-4285, 2003 | 96 | 2003 |
| Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic M Pizzonero, S Dupont, M Babel, S Beaumont, N Bienvenu, R Blanqué, ... Journal of medicinal chemistry 57 (23), 10044-10057, 2014 | 94 | 2014 |
| Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1, 2, 4-oxadiazole EthR inhibitors M Flipo, M Desroses, N Lecat-Guillet, B Villemagne, N Blondiaux, ... Journal of medicinal chemistry 55 (1), 68-83, 2012 | 93 | 2012 |
| Proinflammatory Activity of a Cecropin-Like Antibacterial Peptide from Helicobacter pylori J Bylund, T Christophe, F Boulay, T Nyström, A Karlsson, C Dahlgren Antimicrobial agents and chemotherapy 45 (6), 1700-1704, 2001 | 81 | 2001 |
| High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery T Christophe, F Ewann, HK Jeon, J Cechetto, P Brodin Future medicinal chemistry 2 (8), 1283-1293, 2010 | 71 | 2010 |
| High-content screening in infectious diseases P Brodin, T Christophe Current opinion in chemical biology 15 (4), 534-539, 2011 | 66 | 2011 |
Auguste GenovesioEcole Normale SupérieureVerified email at ens.psl.eu
