An automated approach for clustering an ensemble of NMR-derived protein structures into conformationally related subfamilies LA Kelley, SP Gardner, MJ Sutcliffe Protein Engineering, Design and Selection 9 (11), 1063-1065, 1996 | 572 | 1996 |
Knowledge based modelling of homologous proteins, Part I: Three-dimensional frameworks derived from the simultaneous superposition of multiple structures MJ Sutcliffe, I Haneef, D Carney, TL Blundell Protein Engineering, Design and Selection 1 (5), 377-384, 1987 | 548 | 1987 |
Crystal structure of a PDZ domain JHM Cabral, C Petosa, MJ Sutcliffe, S Raza, O Byron, F Poy, SM Marfatia, ... Nature 382 (6592), 649-652, 1996 | 438 | 1996 |
Atomic description of an enzyme reaction dominated by proton tunneling L Masgrau, A Roujeinikova, LO Johannissen, P Hothi, J Basran, ... Science 312 (5771), 237-241, 2006 | 395 | 2006 |
Knowledge‐based protein modelling and design T Blundell, D Carney, S Gardner, F Hayes, B Howlin, T Hubbard, ... European Journal of Biochemistry 172 (3), 513-520, 1988 | 348 | 1988 |
Knowledge based modelling of homologous proteins, Part II: Rules for the conformations of substituted sidechains MJ Sutcliffe, FRF Hayes, TL Blundell Protein Engineering, Design and Selection 1 (5), 385-392, 1987 | 332 | 1987 |
Enzymatic H-transfer requires vibration-driven extreme tunneling J Basran, MJ Sutcliffe, NS Scrutton Biochemistry 38 (10), 3218-3222, 1999 | 287 | 1999 |
Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: Sequential metabolism of deltamethrin revealed BJ Stevenson, J Bibby, P Pignatelli, S Muangnoicharoen, PM O’Neill, ... Insect biochemistry and molecular biology 41 (7), 492-502, 2011 | 269 | 2011 |
A single aspartate residue is involved in both intrinsic gating and blockage by Mg2+ of the inward rectifier, IRK1. PR Stanfield, NW Davies, PA Shelton, MJ Sutcliffe, IA Khan, WJ Brammar, ... The Journal of physiology 478 (1), 1-6, 1994 | 245 | 1994 |
Ligand binding to integrin αIIbβ3 is dependent on a MIDAS-like domain in the β3 subunit EC Tozer, RC Liddington, MJ Sutcliffe, AH Smeeton, JC Loftus Journal of Biological Chemistry 271 (36), 21978-21984, 1996 | 221 | 1996 |
A model for human cytochrome P450 2D6 based on homology modeling and NMR studies of substrate binding S Modi, MJ Paine, MJ Sutcliffe, LY Lian, WU Primrose, CR Wolf, ... Biochemistry 35 (14), 4540-4550, 1996 | 221 | 1996 |
A single mutation in cytochrome P450 BM3 changes substrate orientation in a catalytic intermediate and the regiospecificity of hydroxylation CF Oliver, S Modi, MJ Sutcliffe, WU Primrose, LY Lian, GCK Roberts Biochemistry 36 (7), 1567-1572, 1997 | 203 | 1997 |
TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies M MacFarlane, SL Kohlhaas, MJ Sutcliffe, MJS Dyer, GM Cohen Cancer research 65 (24), 11265-11270, 2005 | 199 | 2005 |
The catalytic mechanism of cytochrome P450 BM3 involves a 6 Å movement of the bound substrate on reduction S Modi, MJ Sutcliffe, WU Primrose, LY Lian, GCK Roberts Nature structural biology 3 (5), 414-417, 1996 | 168 | 1996 |
Biodiversity of cytochrome P450 redox systems KJ McLean, M Sabri, KR Marshall, RJ Lawson, DG Lewis, D Clift, ... Biochemical Society Transactions 33 (4), 796-801, 2005 | 167 | 2005 |
A new conceptual framework for enzyme catalysis: Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes MJ Sutcliffe, NS Scrutton European Journal of Biochemistry 269 (13), 3096-3102, 2002 | 167 | 2002 |
Structure of hen lysozyme in solution LJ Smith, MJ Sutcliffe, C Redfield, CM Dobson Journal of molecular biology 229 (4), 930-944, 1993 | 159 | 1993 |
Analysis of. vphi. and. chi. 1 torsion angles for hen lysozyme in solution from proton NMR spin-spin coupling constants LJ Smith, MJ Sutcliffe, C Redfield, CM Dobson Biochemistry 30 (4), 986-996, 1991 | 151 | 1991 |
Drug block of the hERG potassium channel: insight from modeling PJ Stansfeld, P Gedeck, M Gosling, B Cox, JS Mitcheson, MJ Sutcliffe Proteins: Structure, Function, and Bioinformatics 68 (2), 568-580, 2007 | 142 | 2007 |
[23] Protein-ligand interactions: Exchange processes and determination of ligand conformation and protein-ligand contacts LY Lian, IL Barsukov, MJ Sutcliffe, KH Sze, GCK Roberts Methods in enzymology 239, 657-700, 1994 | 137 | 1994 |