A bivalent chromatin structure marks key developmental genes in embryonic stem cells BE Bernstein, TS Mikkelsen, X Xie, M Kamal, DJ Huebert, J Cuff, B Fry, ... Cell 125 (2), 315-326, 2006 | 6154 | 2006 |
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells TS Mikkelsen, M Ku, DB Jaffe, B Issac, E Lieberman, G Giannoukos, ... Nature 448 (7153), 553-560, 2007 | 4853 | 2007 |
Direct conversion of fibroblasts to functional neurons by defined factors T Vierbuchen, A Ostermeier, ZP Pang, Y Kokubu, TC Südhof, M Wernig Nature 463 (7284), 1035-1041, 2010 | 3636 | 2010 |
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state M Wernig, A Meissner, R Foreman, T Brambrink, M Ku, K Hochedlinger, ... nature 448 (7151), 318-324, 2007 | 3541 | 2007 |
Polycomb complexes repress developmental regulators in murine embryonic stem cells LA Boyer, K Plath, J Zeitlinger, T Brambrink, LA Medeiros, TI Lee, ... nature 441 (7091), 349-353, 2006 | 3023 | 2006 |
Genome-scale DNA methylation maps of pluripotent and differentiated cells A Meissner, TS Mikkelsen, H Gu, M Wernig, J Hanna, A Sivachenko, ... Nature 454 (7205), 766-770, 2008 | 2970 | 2008 |
In vitro differentiation of transplantable neural precursors from human embryonic stem cells SC Zhang, M Wernig, ID Duncan, O Brüstle, JA Thomson Nature biotechnology 19 (12), 1129-1133, 2001 | 2426 | 2001 |
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin J Hanna, M Wernig, S Markoulaki, CW Sun, A Meissner, JP Cassady, ... Science 318 (5858), 1920-1923, 2007 | 2130 | 2007 |
Dissecting direct reprogramming through integrative genomic analysis TS Mikkelsen, J Hanna, X Zhang, M Ku, M Wernig, P Schorderet, ... Nature 454 (7200), 49-55, 2008 | 1843 | 2008 |
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells A Marson, SS Levine, MF Cole, GM Frampton, T Brambrink, S Johnstone, ... cell 134 (3), 521-533, 2008 | 1764 | 2008 |
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease M Wernig, JP Zhao, J Pruszak, E Hedlund, D Fu, F Soldner, V Broccoli, ... Proceedings of the National Academy of Sciences 105 (15), 5856-5861, 2008 | 1684 | 2008 |
Induction of human neuronal cells by defined transcription factors ZP Pang, N Yang, T Vierbuchen, A Ostermeier, DR Fuentes, TQ Yang, ... Nature 476 (7359), 220-223, 2011 | 1475 | 2011 |
Rapid single-step induction of functional neurons from human pluripotent stem cells Y Zhang, CH Pak, Y Han, H Ahlenius, Z Zhang, S Chanda, S Marro, ... Neuron 78 (5), 785-798, 2013 | 1454 | 2013 |
m6A RNA modification controls cell fate transition in mammalian embryonic stem cells PJ Batista, B Molinie, J Wang, K Qu, J Zhang, L Li, DM Bouley, E Lujan, ... Cell stem cell 15 (6), 707-719, 2014 | 1135 | 2014 |
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency J Hanna, S Markoulaki, P Schorderet, BW Carey, C Beard, M Wernig, ... cell 133 (2), 250-264, 2008 | 1131 | 2008 |
Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells T Brambrink, R Foreman, GG Welstead, CJ Lengner, M Wernig, H Suh, ... Cell stem cell 2 (2), 151-159, 2008 | 1075 | 2008 |
Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells A Meissner, M Wernig, R Jaenisch Nature biotechnology 25 (10), 1177-1181, 2007 | 1002 | 2007 |
c-Myc is dispensable for direct reprogramming of mouse fibroblasts M Wernig, A Meissner, JP Cassady, R Jaenisch Cell stem cell 2 (1), 10-12, 2008 | 845 | 2008 |
Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons OL Wapinski, T Vierbuchen, K Qu, QY Lee, S Chanda, DR Fuentes, ... Cell 155 (3), 621-635, 2013 | 633 | 2013 |
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types M Wernig, CJ Lengner, J Hanna, MA Lodato, E Steine, R Foreman, ... Nature biotechnology 26 (8), 916-924, 2008 | 577 | 2008 |