| Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) MJA DJ Klionsky, K Abdelmohsen, A Abe Autophagy 12 (1), 2016 | 7138 | 2016 |
| mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs RJO Dowling, I Topisirovic, T Alain, M Bidinosti, BD Fonseca, ... Science 328 (5982), 1172-1176, 2010 | 645 | 2010 |
| Targeting the translation machinery in cancer M Bhat, N Robichaud, L Hulea, N Sonenberg, J Pelletier, I Topisirovic Nature reviews Drug discovery 14 (4), 261-278, 2015 | 531 | 2015 |
| mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation M Morita, SP Gravel, V Chénard, K Sikström, L Zheng, T Alain, V Gandin, ... Cell metabolism 18 (5), 698-711, 2013 | 480 | 2013 |
| Dissecting the role of mTOR: lessons from mTOR inhibitors RJO Dowling, I Topisirovic, BD Fonseca, N Sonenberg Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (3), 433-439, 2010 | 448 | 2010 |
| Cap and cap‐binding proteins in the control of gene expression I Topisirovic, YV Svitkin, N Sonenberg, AJ Shatkin Wiley Interdisciplinary Reviews: RNA 2 (2), 277-298, 2011 | 318 | 2011 |
| eIF4E is a central node of an RNA regulon that governs cellular proliferation B Culjkovic, I Topisirovic, L Skrabanek, M Ruiz-Gutierrez, KLB Borden The Journal of cell biology 175 (3), 415-426, 2006 | 295 | 2006 |
| Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities I Topisirovic, M Ruiz-Gutierrez, KLB Borden Cancer research 64 (23), 8639-8642, 2004 | 279 | 2004 |
| Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap A Kentsis, I Topisirovic, B Culjkovic, L Shao, KLB Borden Proceedings of the National Academy of Sciences 101 (52), 18105-18110, 2004 | 272 | 2004 |
| mTOR coordinates protein synthesis, mitochondrial activity and proliferation M Morita, SP Gravel, L Hulea, O Larsson, M Pollak, J St-Pierre, ... Cell cycle 14 (4), 473-480, 2015 | 251 | 2015 |
| Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis I Topisirovic, ML Guzman, MJ McConnell, JD Licht, B Culjkovic, ... Molecular and cellular biology 23 (24), 8992-9002, 2003 | 215 | 2003 |
| eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3′ UTR B Culjkovic, I Topisirovic, L Skrabanek, M Ruiz-Gutierrez, KLB Borden The Journal of cell biology 169 (2), 245-256, 2005 | 204 | 2005 |
| Controlling gene expression through RNA regulons: the role of the eukaryotic translation initiation factor eIF4E B Culjkovic, I Topisirovic, KLB Borden Cell cycle 6 (1), 65-69, 2007 | 194 | 2007 |
| The proline‐rich homeodomain protein, PRH, is a tissue‐specific inhibitor of eIF4E‐dependent cyclin D1 mRNA transport and growth I Topisirovic, B Culjkovic, N Cohen, JM Perez, L Skrabanek, KLB Borden The EMBO journal 22 (3), 689-703, 2003 | 186 | 2003 |
| S6K1 plays a critical role in early adipocyte differentiation LS Carnevalli, K Masuda, F Frigerio, O Le Bacquer, SH Um, V Gandin, ... Developmental cell 18 (5), 763-774, 2010 | 185 | 2010 |
| Regulation of mRNA translation by signaling pathways PP Roux, I Topisirovic Cold Spring Harbor perspectives in biology 4 (11), a012252, 2012 | 177 | 2012 |
| Distinct perturbation of the translatome by the antidiabetic drug metformin O Larsson, M Morita, I Topisirovic, T Alain, MJ Blouin, M Pollak, ... Proceedings of the National Academy of Sciences 109 (23), 8977-8982, 2012 | 177 | 2012 |
| Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection M Jaramillo, MA Gomez, O Larsson, MT Shio, I Topisirovic, I Contreras, ... Cell host & microbe 9 (4), 331-341, 2011 | 157 | 2011 |
| Translational control of immune responses: from transcripts to translatomes CA Piccirillo, E Bjur, I Topisirovic, N Sonenberg, O Larsson Nature immunology 15 (6), 503-511, 2014 | 154 | 2014 |
| eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies T Alain, M Morita, BD Fonseca, A Yanagiya, N Siddiqui, M Bhat, D Zammit, ... Cancer research 72 (24), 6468-6476, 2012 | 149 | 2012 |
Nahum SonenbergGilman Cheney Professor in BiochemistryVerified email at mcgill.ca
