| Lead discovery using molecular docking BK Shoichet, SL McGovern, B Wei, JJ Irwin Current opinion in chemical biology 6 (4), 439-446, 2002 | 612 | 2002 |
| A second fatty acid amide hydrolase with variable distribution among placental mammals BQ Wei, TS Mikkelsen, MK McKinney, ES Lander, BF Cravatt Journal of Biological Chemistry 281 (48), 36569-36578, 2006 | 393 | 2006 |
| Testing a flexible-receptor docking algorithm in a model binding site BQ Wei, LH Weaver, AM Ferrari, BW Matthews, BK Shoichet Journal of molecular biology 337 (5), 1161-1182, 2004 | 290 | 2004 |
| A streamlined platform for high-content functional proteomics of primary human specimens N Jessani, S Niessen, BQQ Wei, M Nicolau, M Humphrey, Y Ji, W Han, ... Nature methods 2 (9), 691-697, 2005 | 288 | 2005 |
| Soft docking and multiple receptor conformations in virtual screening AM Ferrari, BQ Wei, L Costantino, BK Shoichet Journal of medicinal chemistry 47 (21), 5076-5084, 2004 | 275 | 2004 |
| A model binding site for testing scoring functions in molecular docking BQ Wei, WA Baase, LH Weaver, BW Matthews, BK Shoichet Journal of molecular biology 322 (2), 339-355, 2002 | 242 | 2002 |
| Discovery of a potent, selective, and orally available class I phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) kinase inhibitor (GDC-0980) for the … DP Sutherlin, L Bao, M Berry, G Castanedo, I Chuckowree, J Dotson, ... Journal of medicinal chemistry 54 (21), 7579-7587, 2011 | 212 | 2011 |
| Discovery of GDC-0853: a potent, selective, and noncovalent Bruton’s tyrosine kinase inhibitor in early clinical development JJ Crawford, AR Johnson, DL Misner, LD Belmont, G Castanedo, R Choy, ... Journal of medicinal chemistry 61 (6), 2227-2245, 2018 | 177 | 2018 |
| Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition A Boudreau, HE Purkey, A Hitz, K Robarge, D Peterson, S Labadie, ... Nature chemical biology 12 (10), 779-786, 2016 | 174 | 2016 |
| Discovery of 2-{3-[2-(1-Isopropyl-3-methyl-1H-1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide … CO Ndubaku, TP Heffron, ST Staben, M Baumgardner, N Blaquiere, ... Journal of medicinal chemistry 56 (11), 4597-4610, 2013 | 174 | 2013 |
| Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody–drug conjugates LR Staben, SG Koenig, SM Lehar, R Vandlen, D Zhang, J Chuh, SF Yu, ... Nature chemistry 8 (12), 1112-1119, 2016 | 113 | 2016 |
| Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough S Soelaiman, BQ Wei, P Bergson, YS Lee, Y Shen, M Mrksich, ... Journal of Biological Chemistry 278 (28), 25990-25997, 2003 | 108 | 2003 |
| High-throughput cysteine scanning to identify stable antibody conjugation sites for maleimide-and disulfide-based linkers R Ohri, S Bhakta, A Fourie-O’Donohue, J dela Cruz-Chuh, SP Tsai, ... Bioconjugate Chemistry 29 (2), 473-485, 2018 | 86 | 2018 |
| Identification of substituted 2-thio-6-oxo-1, 6-dihydropyrimidines as inhibitors of human lactate dehydrogenase PS Dragovich, BP Fauber, LB Corson, CZ Ding, C Eigenbrot, HX Ge, ... Bioorganic & medicinal chemistry letters 23 (11), 3186-3194, 2013 | 85 | 2013 |
| Pyrrolobenzodiazepines and conjugates thereof PW Howard, JA Flygare, T Pillow, BQ Wei US Patent 9,821,074, 2017 | 82 | 2017 |
| The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5 … TP Heffron, RA Heald, C Ndubaku, BQ Wei, M Augistin, S Do, K Edgar, ... Journal of medicinal chemistry 59 (3), 985-1002, 2016 | 78 | 2016 |
| Rational design of phosphoinositide 3-kinase α inhibitors that exhibit selectivity over the phosphoinositide 3-kinase β isoform TP Heffron, BQ Wei, A Olivero, ST Staben, V Tsui, S Do, J Dotson, ... Journal of medicinal chemistry 54 (22), 7815-7833, 2011 | 75 | 2011 |
| Discovery and optimization of a novel spiropyrrolidine inhibitor of β-secretase (BACE1) through fragment-based drug design IV Efremov, FF Vajdos, KA Borzilleri, S Capetta, H Chen, PH Dorff, ... Journal of medicinal chemistry 55 (21), 9069-9088, 2012 | 70 | 2012 |
| Discovery of peptidomimetic antibody–drug conjugate linkers with enhanced protease specificity BQ Wei, J Gunzner-Toste, H Yao, T Wang, J Wang, Z Xu, J Chen, J Wai, ... Journal of medicinal chemistry 61 (3), 989-1000, 2018 | 68 | 2018 |
| Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase BP Fauber, PS Dragovich, J Chen, LB Corson, CZ Ding, C Eigenbrot, ... Bioorganic & medicinal chemistry letters 23 (20), 5533-5539, 2013 | 67 | 2013 |
