| MUC1 and HIF-1alpha signaling crosstalk induces anabolic glucose metabolism to impart gemcitabine resistance to pancreatic cancer SK Shukla, V Purohit, K Mehla, V Gunda, NV Chaika, E Vernucci, RJ King, ... Cancer cell 32 (1), 71-87. e7, 2017 | 459 | 2017 |
| Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia SK Shukla, T Gebregiworgis, V Purohit, NV Chaika, V Gunda, ... Cancer & metabolism 2, 1-19, 2014 | 246 | 2014 |
| MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer NV Chaika, T Gebregiworgis, ME Lewallen, V Purohit, P Radhakrishnan, ... Proceedings of the National Academy of Sciences 109 (34), 13787-13792, 2012 | 227 | 2012 |
| Application of NMR metabolomics to search for human disease biomarkers T Gebregiworgis, R Powers Combinatorial chemistry & high throughput screening 15 (8), 595-610, 2012 | 166 | 2012 |
| Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation Y Kano, T Gebregiworgis, CB Marshall, N Radulovich, BPK Poon, ... | 85 | 2019 |
| A urinary metabolic signature for multiple sclerosis and neuromyelitis optica T Gebregiworgis, HH Nielsen, C Massilamany, A Gangaplara, J Reddy, ... Journal of proteome research 15 (2), 659-666, 2016 | 50 | 2016 |
| Insights into gemcitabine resistance and the potential for therapeutic monitoring T Gebregiworgis, F Bhinderwala, V Purohit, NV Chaika, PK Singh, ... Metabolomics 14, 1-7, 2018 | 29 | 2018 |
| Glucose Limitation Alters Glutamine Metabolism in MUC1-Overexpressing Pancreatic Cancer Cells T Gebregiworgis, V Purohit, SK Shukla, S Tadros, NV Chaika, J Abrego, ... Journal of proteome research 16 (10), 3536-3546, 2017 | 29 | 2017 |
| The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors T Gebregiworgis, Y Kano, J St-Germain, N Radulovich, ML Udaskin, ... Nature communications 12 (1), 6274, 2021 | 28 | 2021 |
| Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety BMM Grant, M Enomoto, SI Back, KY Lee, T Gebregiworgis, N Ishiyama, ... Science Signaling 13 (625), eaaz0344, 2020 | 27 | 2020 |
| Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine–dependent interface: a model for KRAS oligomerization KY Lee, M Enomoto, T Gebregiworgis, GMC Gasmi-Seabrook, M Ikura, ... Chemical Science 12 (38), 12827-12837, 2021 | 22 | 2021 |
| Lung cancer driven by BRAFG469V mutation is targetable by EGFR kinase inhibitors KG Huo, H Notsuda, Z Fang, NF Liu, T Gebregiworgis, Q Li, NA Pham, ... Journal of Thoracic Oncology 17 (2), 277-288, 2022 | 17 | 2022 |
| Potential of urinary metabolites for diagnosing multiple sclerosis T Gebregiworgis, C Massilamany, A Gangaplara, S Thulasingam, V Kolli, ... ACS chemical biology 8 (4), 684-690, 2013 | 17 | 2013 |
| NMR in integrated biophysical drug discovery for RAS: Past, present, and future CB Marshall, F KleinJan, T Gebregiworgis, KY Lee, Z Fang, BJ Eves, ... Journal of Biomolecular NMR 74, 531-554, 2020 | 13 | 2020 |
| Regulation of GTPase function by autophosphorylation CW Johnson, HS Seo, EM Terrell, MH Yang, F KleinJan, T Gebregiworgis, ... Molecular cell 82 (5), 950-968. e14, 2022 | 12 | 2022 |
| Multiplexed real-time NMR GTPase assay for simultaneous monitoring of multiple guanine nucleotide exchange factor activities from human cancer cells and organoids T Gebregiworgis, CB Marshall, T Nishikawa, N Radulovich, MJ Sandi, ... Journal of the American Chemical Society 140 (13), 4473-4476, 2018 | 11 | 2018 |
| Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia. Cancer Metab. 2014; 2: 18 SK Shukla, T Gebregiworgis, V Purohit, NV Chaika, V Gunda, ... | 10 | |
| Structures of RGL1 RAS-association domain in complex with KRAS and the oncogenic G12V mutant BJ Eves, T Gebregiworgis, GMC Gasmi-Seabrook, DA Kuntz, GG Privé, ... Journal of Molecular Biology 434 (9), 167527, 2022 | 4 | 2022 |
| Altering the regulation of KRAS GTPase cycle via Src and SHP2 creates a potential therapeutic vulnerability for pancreatic cancer T Gebregiworgis, CB Marshall, Y Kano, N Radulovich, MS Tsao, M Ohh, ... Cancer Research 78 (13_Supplement), 4360-4360, 2018 | 1 | 2018 |
| Author Correction: Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis D Murthy, KS Attri, SK Shukla, R Thakur, NV Chaika, C He, D Wang, K Jha, ... Nature cell biology, 2024 | | 2024 |
Robert PowersProfessor of Chemistry, University of NebraskaVerifierad e-postadress på unl.edu
