| The role of p53 in apoptosis JD Amaral, JM Xavier, CJ Steer, CM Rodrigues Discovery medicine 9 (45), 145-152, 2010 | 507 | 2010 |
| Bile acids: regulation of apoptosis by ursodeoxycholic acid JD Amaral, RJS Viana, RM Ramalho, CJ Steer, CMP Rodrigues Journal of lipid research 50 (9), 1721-1734, 2009 | 447 | 2009 |
| TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice AF Nunes, JD Amaral, AC Lo, MB Fonseca, RJS Viana, Z Callaerts-Vegh, ... Molecular neurobiology 45, 440-454, 2012 | 176 | 2012 |
| Activation of necroptosis in human and experimental cholestasis MB Afonso, PM Rodrigues, AL Simão, D Ofengeim, T Carvalho, ... Cell Death & Disease 7 (9), e2390-e2390, 2016 | 117 | 2016 |
| Efficient recovery of proteins from multiple source samples after trizol® or trizol®LS RNA extraction and long-term storage AES Simões, DM Pereira, JD Amaral, AF Nunes, SE Gomes, ... BMC genomics 14, 1-15, 2013 | 111 | 2013 |
| p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis JD Amaral, RE Castro, S Solá, CJ Steer, CÁMP Rodrigues Journal of biological chemistry 282 (47), 34250-34259, 2007 | 110 | 2007 |
| Amyloid-β pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset PA Dionísio, JD Amaral, MF Ribeiro, AC Lo, R D'Hooge, CMP Rodrigues Neurobiology of aging 36 (1), 228-240, 2015 | 106 | 2015 |
| Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF‐β1–induced apoptosis in rat hepatocytes S Solá, JD Amaral, RE Castro, RM Ramalho, PM Borralho, BT Kren, ... Hepatology 42 (4), 925-934, 2005 | 89 | 2005 |
| Targeting the p53 pathway of apoptosis J D Amaral, J M Xavier, C J Steer, C MP Rodrigues Current pharmaceutical design 16 (22), 2493-2503, 2010 | 75 | 2010 |
| Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid β-peptide-induced apoptosis S Sola, JD Amaral, PM Borralho, RM Ramalho, RE Castro, MM Aranha, ... Molecular endocrinology 20 (10), 2292-2303, 2006 | 65 | 2006 |
| Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents CJA Ribeiro, JD Amaral, CMP Rodrigues, R Moreira, MMM Santos Bioorganic & medicinal chemistry 22 (1), 577-584, 2014 | 64 | 2014 |
| Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice RM Ramalho, AF Nunes, RB Dias, JD Amaral, AC Lo, R D'Hooge, ... Neurobiology of aging 34 (2), 551-561, 2013 | 57 | 2013 |
| p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis JD Amaral, RE Castro, CJ Steer, CMP Rodrigues Trends in molecular medicine 15 (11), 531-541, 2009 | 53 | 2009 |
| Loss of microglial parkin inhibits necroptosis and contributes to neuroinflammation PEA Dionísio, SR Oliveira, JSJD Amaral, CMP Rodrigues Molecular Neurobiology 56, 2990-3004, 2019 | 50 | 2019 |
| Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes RE Castro, JD Amaral, S Solá, BT Kren, CJ Steer, CMP Rodrigues American Journal of Physiology-Gastrointestinal and Liver Physiology 293 (1 …, 2007 | 49 | 2007 |
| Modulation of hepatocyte apoptosis: cross-talk between bile acids and nuclear steroid receptors S Sola, JD Amaral, MM Aranha, CJ Steer, P Rodrigues Current medicinal chemistry 13 (25), 3039-3051, 2006 | 48 | 2006 |
| Copper complex nanoformulations featuring highly promising therapeutic potential in murine melanoma models JO Pinho, JD Amaral, RE Castro, CMP Rodrigues, A Casini, G Soveral, ... Nanomedicine 14 (7), 835-850, 2019 | 43 | 2019 |
| Adaptation to carbon starvation: RNase III ensures normal expression levels of bolA1p mRNA and σS P Freire, JD Amaral, JM Santos, CM Arraiano Biochimie 88 (3-4), 341-346, 2006 | 33 | 2006 |
| In vitro targeting of colon cancer cells using spiropyrazoline oxindoles RC Nunes, CJA Ribeiro, Â Monteiro, CMP Rodrigues, JD Amaral, ... European Journal of Medicinal Chemistry 139, 168-179, 2017 | 31 | 2017 |
| Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties CJA Ribeiro, RC Nunes, JD Amaral, LM Goncalves, CMP Rodrigues, ... European Journal of Medicinal Chemistry 140, 494-509, 2017 | 29 | 2017 |
