| BACE1 is the major β-secretase for generation of Aβ peptides by neurons H Cai, Y Wang, D McCarthy, H Wen, DR Borchelt, DL Price, PC Wong Nature neuroscience 4 (3), 233-234, 2001 | 1458 | 2001 |
| BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions FM Laird, H Cai, AV Savonenko, MH Farah, K He, T Melnikova, H Wen, ... Journal of Neuroscience 25 (50), 11693-11709, 2005 | 675 | 2005 |
| Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients R Li, K Lindholm, LB Yang, X Yue, M Citron, R Yan, T Beach, L Sue, ... Proceedings of the National Academy of Sciences 101 (10), 3632-3637, 2004 | 650 | 2004 |
| Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant α-synuclein X Lin, L Parisiadou, XL Gu, L Wang, H Shim, L Sun, C Xie, CX Long, ... Neuron 64 (6), 807-827, 2009 | 578 | 2009 |
| The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease Z Liu, J Lee, S Krummey, W Lu, H Cai, MJ Lenardo Nature immunology 12 (11), 1063-1070, 2011 | 393 | 2011 |
| Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis L Parisiadou, C Xie, HJ Cho, X Lin, XL Gu, CX Long, E Lobbestael, ... Journal of Neuroscience 29 (44), 13971-13980, 2009 | 368 | 2009 |
| Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice XL Gu, CX Long, L Sun, C Xie, X Lin, H Cai Molecular brain 3, 1-16, 2010 | 351 | 2010 |
| Cloning and characterization of neuropilin-1-interacting protein: a PSD-95/Dlg/ZO-1 domain-containing protein that interacts with the cytoplasmic domain of neuropilin-1 H Cai, RR Reed Journal of Neuroscience 19 (15), 6519-6527, 1999 | 351 | 1999 |
| Autophagy in neurodegenerative diseases: pathogenesis and therapy F Guo, X Liu, H Cai, W Le Brain pathology 28 (1), 3-13, 2018 | 324 | 2018 |
| Deletion at ITPR1 Underlies Ataxia in Mice and Spinocerebellar Ataxia 15 in Humans J Van De Leemput, J Chandran, MA Knight, LA Holtzclaw, S Scholz, ... PLoS genetics 3 (6), e108, 2007 | 317 | 2007 |
| Genetically engineered mouse models of neurodegenerative diseases PC Wong, H Cai, DR Borchelt, DL Price Nature neuroscience 5 (7), 633-639, 2002 | 308 | 2002 |
| MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein HJ Cho, G Liu, SM Jin, L Parisiadou, C Xie, J Yu, L Sun, B Ma, J Ding, ... Human molecular genetics 22 (3), 608-620, 2013 | 288 | 2013 |
| RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways MP Van Der Brug, J Blackinton, J Chandran, LY Hao, A Lal, ... Proceedings of the National Academy of Sciences 105 (29), 10244-10249, 2008 | 252 | 2008 |
| Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway Y Tong, E Giaime, H Yamaguchi, T Ichimura, Y Liu, H Si, H Cai, ... Molecular neurodegeneration 7, 1-16, 2012 | 250 | 2012 |
| Nicastrin is required for assembly of presenilin/γ-secretase complexes to mediate Notch signaling and for processing and trafficking of β-amyloid precursor protein in mammals T Li, G Ma, H Cai, DL Price, PC Wong Journal of Neuroscience 23 (8), 3272-3277, 2003 | 230 | 2003 |
| The IkappaB kinase family phosphorylates the Parkinson’s disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling N Dzamko, F Inesta-Vaquera, J Zhang, C Xie, H Cai, S Arthur, L Tan, ... PloS one 7 (6), e39132, 2012 | 227 | 2012 |
| The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2 L Wang, C Xie, E Greggio, L Parisiadou, H Shim, L Sun, J Chandran, ... Journal of Neuroscience 28 (13), 3384-3391, 2008 | 227 | 2008 |
| Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis C Yang, H Wang, T Qiao, B Yang, L Aliaga, L Qiu, W Tan, J Salameh, ... Proceedings of the National Academy of Sciences 111 (12), E1121-E1129, 2014 | 206 | 2014 |
| LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity L Parisiadou, J Yu, C Sgobio, C Xie, G Liu, L Sun, XL Gu, X Lin, ... Nature neuroscience 17 (3), 367-376, 2014 | 203 | 2014 |
| Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of … X Lin, L Parisiadou, C Sgobio, G Liu, J Yu, L Sun, H Shim, XL Gu, J Luo, ... Journal of Neuroscience 32 (27), 9248-9264, 2012 | 197 | 2012 |
Loukia Parisiadou, Ph.D.Northwestern UniversityVerified email at northwestern.edu
