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Randal Halfmann
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A systematic survey identifies prions and illuminates sequence features of prionogenic proteins
S Alberti, R Halfmann, O King, A Kapila, S Lindquist
Cell 137 (1), 146-158, 2009
10862009
Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation
X Cai, J Chen, H Xu, S Liu, QX Jiang, R Halfmann, ZJ Chen
Cell 156 (6), 1207-1222, 2014
5862014
Prions are a common mechanism for phenotypic inheritance in wild yeasts
R Halfmann, DF Jarosz, SK Jones, A Chang, AK Lancaster, S Lindquist
Nature 482 (7385), 363-368, 2012
4592012
Epigenetics in the extreme: prions and the inheritance of environmentally acquired traits
R Halfmann, S Lindquist
Science 330 (6004), 629-632, 2010
2742010
Screening for amyloid aggregation by semi-denaturing detergent-agarose gel electrophoresis
R Halfmann, S Lindquist
Journal of visualized experiments: JoVE, 2008
2232008
Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins
R Halfmann, S Alberti, R Krishnan, N Lyle, CW O'Donnell, OD King, ...
Molecular cell 43 (1), 72-84, 2011
1992011
Chaperone-dependent amyloid assembly protects cells from prion toxicity
PM Douglas, S Treusch, HY Ren, R Halfmann, ML Duennwald, ...
Proceedings of the National Academy of Sciences 105 (20), 7206-7211, 2008
1962008
Prions, protein homeostasis, and phenotypic diversity
R Halfmann, S Alberti, S Lindquist
Trends in cell biology 20 (3), 125-133, 2010
1952010
Heritable remodeling of yeast multicellularity by an environmentally responsive prion
DL Holmes, AK Lancaster, S Lindquist, R Halfmann
Cell 153 (1), 153-165, 2013
1912013
Small-molecule activation of the TRAIL receptor DR5 in human cancer cells
G Wang, X Wang, H Yu, S Wei, N Williams, DL Holmes, R Halfmann, ...
Nature chemical biology 9 (2), 84-89, 2013
1182013
Prion formation by a yeast GLFG nucleoporin
R Halfmann, JR Wright, S Alberti, S Lindquist, M Rexach
Prion 6 (4), 391-399, 2012
1032012
Biochemical, cell biological, and genetic assays to analyze amyloid and prion aggregation in yeast
S Alberti, R Halfmann, S Lindquist
Methods in enzymology 470, 709-734, 2010
852010
Quantifying nucleation in vivo reveals the physical basis of prion-like phase behavior
T Khan, TS Kandola, J Wu, S Venkatesan, E Ketter, JJ Lange, AR Gama, ...
Molecular cell 71 (1), 155-168. e7, 2018
792018
A method for probing the mutational landscape of amyloid structure
CW O'Donnell, J Waldispühl, M Lis, R Halfmann, S Devadas, S Lindquist, ...
Bioinformatics 27 (13), i34-i42, 2011
752011
A self-perpetuating repressive state of a viral replication protein blocks superinfection by the same virus
XF Zhang, R Sun, Q Guo, S Zhang, T Meulia, R Halfmann, D Li, F Qu
PLoS Pathogens 13 (3), e1006253, 2017
492017
Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation
MJ Holliday, A Witt, A Rodríguez Gama, BT Walters, CP Arthur, ...
Nature Communications 10 (1), 3070, 2019
392019
A glass menagerie of low complexity sequences.
R Halfmann
Current Opinion in Structural Biology 38, 9-16, 2016
372016
The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death
NL Nuckolls, AC Mok, JJ Lange, K Yi, TS Kandola, AM Hunn, ...
Elife 9, e55694, 2020
282020
DNCON2_Inter: predicting interchain contacts for homodimeric and homomultimeric protein complexes using multiple sequence alignments of monomers and deep learning
F Quadir, RS Roy, R Halfmann, J Cheng
Scientific reports 11 (1), 12295, 2021
242021
Thermal green protein, an extremely stable, nonaggregating fluorescent protein created by structure‐guided surface engineering
DW Close, CD Paul, PS Langan, MCJ Wilce, DAK Traore, R Halfmann, ...
Proteins: Structure, Function, and Bioinformatics 83 (7), 1225-1237, 2015
232015
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Articles 1–20