Omer Dushek
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Mechanisms for T cell receptor triggering
PA Van Der Merwe, O Dushek
Nature Reviews Immunology 11 (1), 47-55, 2011
Constitutively active Lck kinase in T cells drives antigen receptor signal transduction
K Nika, C Soldani, M Salek, W Paster, A Gray, R Etzensperger, L Fugger, ...
Immunity 32 (6), 766-777, 2010
The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor
B Treanor, D Depoil, A Gonzalez-Granja, P Barral, M Weber, O Dushek, ...
Immunity 32 (2), 187-199, 2010
Effects of common mutations in the SARS-CoV-2 Spike RBD and its ligand, the human ACE2 receptor on binding affinity and kinetics
MI Barton, SA MacGowan, MA Kutuzov, O Dushek, GJ Barton, ...
Elife 10, e70658, 2021
Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time
M Aleksic, O Dushek, H Zhang, E Shenderov, JL Chen, V Cerundolo, ...
Immunity 32 (2), 163-174, 2010
PD‐L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy
A Azad, S Yin Lim, Z D'Costa, K Jones, A Diana, OJ Sansom, P Kruger, ...
EMBO molecular medicine 9 (2), 167-180, 2017
Phenotypic models of T cell activation
M Lever, PK Maini, PA Van Der Merwe, O Dushek
Nature Reviews Immunology 14 (9), 619-629, 2014
Comparison of T cell activities mediated by human TCRs and CARs that use the same recognition domains
DT Harris, MV Hager, SN Smith, Q Cai, JD Stone, P Kruger, M Lever, ...
The Journal of Immunology 200 (3), 1088-1100, 2018
Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling
H Zhang, SP Cordoba, O Dushek, P Anton Van Der Merwe
Proceedings of the National Academy of Sciences 108 (48), 19323-19328, 2011
A THEMIS: SHP 1 complex promotes T‐cell survival
W Paster, AM Bruger, K Katsch, C Grégoire, R Roncagalli, G Fu, ...
The EMBO journal 34 (3), 393-409, 2015
Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose
M Lever, HS Lim, P Kruger, J Nguyen, N Trendel, E Abu-Shah, PK Maini, ...
Proceedings of the National Academy of Sciences 113 (43), E6630-E6638, 2016
Non‐catalytic tyrosine‐phosphorylated receptors
O Dushek, J Goyette, PA van der Merwe
Immunological reviews 250 (1), 258-276, 2012
A role for rebinding in rapid and reliable T cell responses to antigen
O Dushek, R Das, D Coombs
PLoS computational biology 5 (11), e1000578, 2009
Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation
O Dushek, M Aleksic, RJ Wheeler, H Zhang, SP Cordoba, YC Peng, ...
Science signaling 4 (176), ra39-ra39, 2011
The discriminatory power of the T cell receptor
J Pettmann, A Huhn, E Abu Shah, MA Kutuzov, DB Wilson, ML Dustin, ...
Elife 10, e67092, 2021
An induced rebinding model of antigen discrimination
O Dushek, PA Van der Merwe
Trends in immunology 35 (4), 153-158, 2014
Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands
P Robert, M Aleksic, O Dushek, V Cerundolo, P Bongrand, ...
Biophysical journal 102 (2), 248-257, 2012
SpyAvidin hubs enable precise and ultrastable orthogonal nanoassembly
M Fairhead, G Veggiani, M Lever, J Yan, D Mesner, CV Robinson, ...
Journal of the American Chemical Society 136 (35), 12355-12363, 2014
A cell topography-based mechanism for ligand discrimination by the T cell receptor
RA Fernandes, KA Ganzinger, JC Tzou, P Jönsson, SF Lee, M Palayret, ...
Proceedings of the National Academy of Sciences 116 (28), 14002-14010, 2019
Mechanical modulation of receptor-ligand interactions at cell-cell interfaces
JF Allard, O Dushek, D Coombs, PA Van Der Merwe
Biophysical Journal 102 (6), 1265-1273, 2012
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Articles 1–20