Omer Dushek
Omer Dushek
Associate Professor, University of Oxford
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Mechanisms for T cell receptor triggering
PA Van Der Merwe, O Dushek
Nature Reviews Immunology 11 (1), 47-55, 2011
Constitutively active Lck kinase in T cells drives antigen receptor signal transduction
K Nika, C Soldani, M Salek, W Paster, A Gray, R Etzensperger, L Fugger, ...
Immunity 32 (6), 766-777, 2010
The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor
B Treanor, D Depoil, A Gonzalez-Granja, P Barral, M Weber, O Dushek, ...
Immunity 32 (2), 187-199, 2010
Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time
M Aleksic, O Dushek, H Zhang, E Shenderov, JL Chen, V Cerundolo, ...
Immunity 32 (2), 163-174, 2010
Phenotypic models of T cell activation
M Lever, PK Maini, PA Van Der Merwe, O Dushek
Nature Reviews Immunology 14 (9), 619-629, 2014
Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling
H Zhang, SP Cordoba, O Dushek, PA Van Der Merwe
Proceedings of the National Academy of Sciences 108 (48), 19323-19328, 2011
PD‐L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy
A Azad, S Yin Lim, Z D'Costa, K Jones, A Diana, OJ Sansom, P Kruger, ...
EMBO molecular medicine 9 (2), 167-180, 2017
A role for rebinding in rapid and reliable T cell responses to antigen
O Dushek, R Das, D Coombs
PLoS Comput Biol 5 (11), e1000578, 2009
A THEMIS: SHP 1 complex promotes T‐cell survival
W Paster, AM Bruger, K Katsch, C Grégoire, R Roncagalli, G Fu, ...
The EMBO journal 34 (3), 393-409, 2015
Comparison of T cell activities mediated by human TCRs and CARs that use the same recognition domains
DT Harris, MV Hager, SN Smith, Q Cai, JD Stone, P Kruger, M Lever, ...
The Journal of Immunology 200 (3), 1088-1100, 2018
Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose
M Lever, HS Lim, P Kruger, J Nguyen, N Trendel, E Abu-Shah, PK Maini, ...
Proceedings of the National Academy of Sciences 113 (43), E6630-E6638, 2016
Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands
P Robert, M Aleksic, O Dushek, V Cerundolo, P Bongrand, ...
Biophysical journal 102 (2), 248-257, 2012
Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation
O Dushek, M Aleksic, RJ Wheeler, H Zhang, SP Cordoba, YC Peng, ...
Science signaling 4 (176), ra39-ra39, 2011
Ultrasensitivity in Multisite Phosphorylation of Membrane-Anchored Proteins
O Dushek, PA van der Merwe, V Shahrezaei
Biophysical Journal 100 (5), 1189-1197, 2011
An induced rebinding model of antigen discrimination
O Dushek, PA van der Merwe
Trends in immunology 35 (4), 153-158, 2014
Non‐catalytic tyrosine‐phosphorylated receptors
O Dushek, J Goyette, PA van der Merwe
Immunological reviews 250 (1), 258-276, 2012
Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity
H Mukhopadhyay, SP Cordoba, PK Maini, PA van der Merwe, O Dushek
PLoS Comput Biol 9 (3), e1003004, 2013
Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery
O Dushek, S Mueller, S Soubies, D Depoil, I Caramalho, D Coombs, ...
PloS one 3 (12), e3913, 2008
SpyAvidin hubs enable precise and ultrastable orthogonal nanoassembly
M Fairhead, G Veggiani, M Lever, J Yan, D Mesner, CV Robinson, ...
Journal of the American Chemical Society 136 (35), 12355-12363, 2014
Mechanical modulation of receptor-ligand interactions at cell-cell interfaces
JF Allard, O Dushek, D Coombs, PA Van Der Merwe
Biophysical journal 102 (6), 1265-1273, 2012
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