| Mechanisms for T cell receptor triggering PA Van Der Merwe, O Dushek Nature Reviews Immunology 11 (1), 47-55, 2011 | 427 | 2011 |
| Constitutively active Lck kinase in T cells drives antigen receptor signal transduction K Nika, C Soldani, M Salek, W Paster, A Gray, R Etzensperger, L Fugger, ... Immunity 32 (6), 766-777, 2010 | 312 | 2010 |
| The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor B Treanor, D Depoil, A Gonzalez-Granja, P Barral, M Weber, O Dushek, ... Immunity 32 (2), 187-199, 2010 | 292 | 2010 |
| Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time M Aleksic, O Dushek, H Zhang, E Shenderov, JL Chen, V Cerundolo, ... Immunity 32 (2), 163-174, 2010 | 229 | 2010 |
| Phenotypic models of T cell activation M Lever, PK Maini, PA Van Der Merwe, O Dushek Nature Reviews Immunology 14 (9), 619-629, 2014 | 125 | 2014 |
| Basic residues in the T-cell receptor ζ cytoplasmic domain mediate membrane association and modulate signaling H Zhang, SP Cordoba, O Dushek, PA Van Der Merwe Proceedings of the National Academy of Sciences 108 (48), 19323-19328, 2011 | 107 | 2011 |
| PD‐L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy A Azad, S Yin Lim, Z D'Costa, K Jones, A Diana, OJ Sansom, P Kruger, ... EMBO molecular medicine 9 (2), 167-180, 2017 | 91 | 2017 |
| A role for rebinding in rapid and reliable T cell responses to antigen O Dushek, R Das, D Coombs PLoS Comput Biol 5 (11), e1000578, 2009 | 75 | 2009 |
| A THEMIS: SHP 1 complex promotes T‐cell survival W Paster, AM Bruger, K Katsch, C Grégoire, R Roncagalli, G Fu, ... The EMBO journal 34 (3), 393-409, 2015 | 74 | 2015 |
| Comparison of T cell activities mediated by human TCRs and CARs that use the same recognition domains DT Harris, MV Hager, SN Smith, Q Cai, JD Stone, P Kruger, M Lever, ... The Journal of Immunology 200 (3), 1088-1100, 2018 | 61 | 2018 |
| Architecture of a minimal signaling pathway explains the T-cell response to a 1 million-fold variation in antigen affinity and dose M Lever, HS Lim, P Kruger, J Nguyen, N Trendel, E Abu-Shah, PK Maini, ... Proceedings of the National Academy of Sciences 113 (43), E6630-E6638, 2016 | 59 | 2016 |
| Kinetics and mechanics of two-dimensional interactions between T cell receptors and different activating ligands P Robert, M Aleksic, O Dushek, V Cerundolo, P Bongrand, ... Biophysical journal 102 (2), 248-257, 2012 | 59 | 2012 |
| Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation O Dushek, M Aleksic, RJ Wheeler, H Zhang, SP Cordoba, YC Peng, ... Science signaling 4 (176), ra39-ra39, 2011 | 59 | 2011 |
| Ultrasensitivity in Multisite Phosphorylation of Membrane-Anchored Proteins O Dushek, PA van der Merwe, V Shahrezaei Biophysical Journal 100 (5), 1189-1197, 2011 | 57 | 2011 |
| An induced rebinding model of antigen discrimination O Dushek, PA van der Merwe Trends in immunology 35 (4), 153-158, 2014 | 56 | 2014 |
| Non‐catalytic tyrosine‐phosphorylated receptors O Dushek, J Goyette, PA van der Merwe Immunological reviews 250 (1), 258-276, 2012 | 56 | 2012 |
| Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity H Mukhopadhyay, SP Cordoba, PK Maini, PA van der Merwe, O Dushek PLoS Comput Biol 9 (3), e1003004, 2013 | 50 | 2013 |
| Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery O Dushek, S Mueller, S Soubies, D Depoil, I Caramalho, D Coombs, ... PloS one 3 (12), e3913, 2008 | 48 | 2008 |
| SpyAvidin hubs enable precise and ultrastable orthogonal nanoassembly M Fairhead, G Veggiani, M Lever, J Yan, D Mesner, CV Robinson, ... Journal of the American Chemical Society 136 (35), 12355-12363, 2014 | 47 | 2014 |
| Mechanical modulation of receptor-ligand interactions at cell-cell interfaces JF Allard, O Dushek, D Coombs, PA Van Der Merwe Biophysical journal 102 (6), 1265-1273, 2012 | 47 | 2012 |
Philip Anton van der MerweProfessor of Molecular Immunology, University of OxfordVerifierad e-postadress på path.ox.ac.uk
