| Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief A Moriconi, TM Cunha, GR Souza, AH Lopes, FQ Cunha, VL Carneiro, ... Proceedings of the National Academy of Sciences 111 (47), 16937-16942, 2014 | 81 | 2014 |
| Molecular Dynamics Simulation of the Heterodimeric mGluR2/5HT2A Complex. An Atomistic Resolution Study of a Potential New Target in Psychiatric Conditions A Bruno, AE Guadix, G Costantino Journal of chemical information and modeling 49 (6), 1602-1616, 2009 | 62 | 2009 |
| The in silico drug discovery toolbox: applications in lead discovery and optimization A Bruno, G Costantino, L Sartori, M Radi Current Medicinal Chemistry 26 (21), 3838-3873, 2019 | 55 | 2019 |
| Discovery of New Potential Anti‐Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target‐Focused Repurposing Approaches G Annunziato, A Angeli, F D'Alba, A Bruno, M Pieroni, D Vullo, V De Luca, ... ChemMedChem 11 (17), 1904-1914, 2016 | 54 | 2016 |
| Identification of Breast Cancer Inhibitors Specific for G Protein‐Coupled Estrogen Receptor (GPER)‐Expressing Cells F Aiello, G Carullo, F Giordano, E Spina, A Nigro, A Garofalo, S Tassini, ... ChemMedChem 12 (16), 1279-1285, 2017 | 51 | 2017 |
| Indolylarylsulfones Carrying a Heterocyclic Tail as Very Potent and Broad Spectrum HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors http://pubs.acs.org/doi/abs/10.1021/jm5011622 57 (23), 9945–9957, 2014 | 50* | 2014 |
| Accepting the invitation to open innovation in malaria drug discovery: synthesis, biological evaluation, and investigation on the structure–activity relationships of benzo [b … M Pieroni, E Azzali, N Basilico, S Parapini, M Zolkiewski, C Beato, ... Journal of medicinal chemistry 60 (5), 1959-1970, 2017 | 48 | 2017 |
| Structure–activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human … S Castellano, S Taliani, M Viviano, C Milite, E Da Pozzo, B Costa, ... Journal of Medicinal Chemistry 57 (6), 2413-2428, 2014 | 47 | 2014 |
| Molecular mechanism and functional role of brefeldin A-mediated ADP-ribosylation of CtBP1/BARS A Colanzi, G Grimaldi, G Catara, C Valente, C Cericola, P Liberali, ... Proceedings of the National Academy of Sciences 110 (24), 9794-9799, 2013 | 47 | 2013 |
| Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments M Stornaiuolo, A Bruno, L Botta, GL Regina, S Cosconati, R Silvestri, ... Scientific reports 5 (1), 15453, 2015 | 46 | 2015 |
| Membrane-sensitive conformational states of helix 8 in the metabotropic Glu2 receptor, a class C GPCR A Bruno, G Costantino, G De Fabritiis, M Pastor, J Selent Public Library of Science 7 (8), e42023, 2012 | 46 | 2012 |
| Design and synthesis of trans-2-substituted-cyclopropane-1-carboxylic acids as the first non-natural small molecule inhibitors of O-acetylserine sulfhydrylase L Amori, S Katkevica, A Bruno, B Campanini, P Felici, A Mozzarelli, ... MedChemComm 3 (9), 1111-1116, 2012 | 46 | 2012 |
| Pharmacological folding chaperones act as allosteric ligands of Frizzled4 SF Generoso, M Giustiniano, G La Regina, S Bottone, S Passacantilli, ... Nature Chemical Biology 11 (4), 280-286, 2015 | 45 | 2015 |
| Beyond radio-displacement techniques for Identification of CB1 Ligands: The First Application of a Fluorescence-quenching Assay A Bruno, F Lembo, E Novellino, M Stornaiuolo, L Marinelli Scientific Reports 4 (1), 3757, 2014 | 33 | 2014 |
| Unbinding pathways from the glucocorticoid receptor shed light on the reduced sensitivity of glucocorticoid ligands to a naturally occurring, clinically relevant mutant receptor AM Capelli, A Bruno, A Entrena Guadix, G Costantino Journal of medicinal chemistry 56 (17), 7003-7014, 2013 | 33 | 2013 |
| Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides E Barresi, A Bruno, S Taliani, S Cosconati, E Da Pozzo, S Salerno, ... Journal of Medicinal Chemistry 58 (15), 6081-6092, 2015 | 32 | 2015 |
| Synthesis, biological activity and molecular modeling of new biphenylic carboxamides as potent and selective CB2 receptor ligands S Bertini, T Parkkari, JR Savinainen, C Arena, G Saccomanni, S Saguto, ... European Journal of Medicinal Chemistry 90, 526-536, 2015 | 28 | 2015 |
| Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer … G Annunziato, M Pieroni, R Benoni, B Campanini, TA Pertinhez, ... Journal of Enzyme Inhibition and Medicinal Chemistry 31 (sup4), 78-87, 2016 | 26 | 2016 |
| The aryl hydrocarbon receptor (AhR) mediates the counter-regulatory effects of pelargonidins in models of inflammation and metabolic dysfunctions M Biagioli, A Carino, C Fiorucci, G Annunziato, S Marchianò, M Bordoni, ... Nutrients 11 (8), 1820, 2019 | 24 | 2019 |
| Alpha-synuclein/synapsin III pathological interplay boosts the motor response to methylphenidate G Faustini, F Longhena, A Bruno, F Bono, J Grigoletto, L La Via, A Barbon, ... Neurobiology of disease 138, 104789, 2020 | 23 | 2020 |
