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Richard J Lewis
Richard J Lewis
Medicinal Chemistry, RIA IMED, AstraZeneca
Verified email at astrazeneca.com
Title
Cited by
Cited by
Year
From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis
B Springthorpe, A Bailey, P Barton, TN Birkinshaw, RV Bonnert, ...
Bioorganic & medicinal chemistry letters 17 (21), 6013-6018, 2007
2902007
Structural and conformational determinants of macrocycle cell permeability
B Over, P Matsson, C Tyrchan, P Artursson, BC Doak, MA Foley, ...
Nature Chemical Biology 12 (12), 1065-1074, 2016
1712016
Utilization of SABRE-derived hyperpolarization to detect low-concentration analytes via 1D and 2D NMR methods
LS Lloyd, RW Adams, M Bernstein, S Coombes, SB Duckett, GGR Green, ...
Journal of the American Chemical Society 134 (31), 12904-12907, 2012
1322012
Hyperpolarisation through reversible interactions with para hydrogen
LS Lloyd, A Asghar, MJ Burns, A Charlton, S Coombes, MJ Cowley, ...
Catalysis Science & Technology 4 (10), 3544-3554, 2014
972014
Optimization of monocarboxylate transporter 1 blockers through analysis and modulation of atropisomer interconversion properties
SD Guile, JR Bantick, ME Cooper, DK Donald, C Eyssade, AH Ingall, ...
Journal of medicinal chemistry 50 (2), 254-263, 2007
692007
A comparison of capillary‐scale LC–NMR with alternative techniques: spectroscopic and practical considerations
RJ Lewis, MA Bernstein, SJ Duncan, CJ Sleigh
Magnetic Resonance in Chemistry 43 (9), 783-789, 2005
602005
Structure-guided discovery of potent and selective inhibitors of ERK1/2 from a modestly active and promiscuous chemical start point
RA Ward, P Bethel, C Cook, E Davies, JE Debreczeni, G Fairley, L Feron, ...
Journal of medicinal chemistry 60 (8), 3438-3450, 2017
522017
Discovery of a potent and selective oral inhibitor of ERK1/2 (AZD0364) that is efficacious in both monotherapy and combination therapy in models of nonsmall cell lung cancer …
RA Ward, MJ Anderton, P Bethel, J Breed, C Cook, EJ Davies, A Dobson, ...
Journal of medicinal chemistry 62 (24), 11004-11018, 2019
462019
The importance of ion-pairing in peptide purification by reversed-phase liquid chromatography
D Åsberg, AL Weinmann, T Leek, RJ Lewis, M Klarqvist, M Leśko, ...
Journal of Chromatography A 1496, 80-91, 2017
382017
Impact of excited-state antiaromaticity relief in a fundamental benzene photoreaction leading to substituted bicyclo [3.1. 0] hexenes
T Slanina, R Ayub, J Toldo, J Sundell, W Rabten, M Nicaso, I Alabugin, ...
Journal of the American Chemical Society 142 (25), 10942-10954, 2020
352020
Selective excitation of overlapping multiplets; the application of doubly selective and chemical shift filter experiments to complex NMR spectra
SJ Duncan, R Lewis, MA Bernstein, P Sandor
Magnetic Resonance in Chemistry 45 (4), 283-288, 2007
342007
Saccharin Aza Bioisosteres Synthesis and Preclinical Property Comparisons
Y Chen, CJ Aurell, A Pettersen, RJ Lewis, MA Hayes, M Lepistö, ...
ACS Medicinal Chemistry Letters 8 (6), 672-677, 2017
272017
Structure–activity studies on amides inhibiting photosystem II
RJ Lewis, P Camilleri, AJ Kirby, CA Marby, AA Slawin, DJ Williams
Journal of the Chemical Society, Perkin Transactions 2, 1625-1630, 1991
271991
Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y2 Receptor Based on AR-C118925
S Conroy, ND Kindon, J Glenn, LA Stoddart, RJ Lewis, SJ Hill, B Kellam, ...
Journal of medicinal chemistry 61 (7), 3089-3113, 2018
232018
Complex Polyheterocycles and the Stereochemical Reassignment of Pileamartine A via Aza-Heck Triggered Aryl C–H Functionalization Cascades
BT Jones, J García-Cárceles, L Caiger, IR Hazelden, RJ Lewis, T Langer, ...
Journal of the American Chemical Society 143 (38), 15593-15598, 2021
222021
Importance of binding site hydration and flexibility revealed when optimizing a macrocyclic inhibitor of the Keap1–Nrf2 protein–protein interaction
F Begnini, S Geschwindner, P Johansson, L Wissler, RJ Lewis, ...
Journal of medicinal chemistry 65 (4), 3473-3517, 2022
182022
Identification and optimization of pyrrolidine derivatives as highly potent ghrelin receptor full agonists
M Cooper, A Llinas, P Hansen, M Caffrey, A Ray, S Sjödin, I Shamovsky, ...
Journal of Medicinal Chemistry 63 (17), 9705-9730, 2020
152020
Which hydroxy? Evidence for species differences in the regioselectivity of glucuronidation in rat, dog, and human in vitro systems and dog in vivo
IJ Martin, RJ Lewis, MA Bernstein, IG Beattie, CA Martin, RJ Riley, ...
Drug metabolism and disposition 34 (9), 1502-1507, 2006
152006
NMR identification of an S-linked glucuronide of a triazole thione formed in vitro
IJ Martin, RJ Lewis, RV Bonnert, P Cage, GC Moody
Drug metabolism and disposition 31 (6), 694-696, 2003
142003
Late-occurring and long-circulating metabolites of GABAAα2, 3 receptor modulator AZD7325 involving metabolic cyclization and aromatization: Relevance to MIST analysis and …
C Gu, M Artelsmair, CS Elmore, RJ Lewis, P Davis, JE Hall, ...
Drug Metabolism and Disposition 46 (3), 303-315, 2018
132018
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