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Jonathan R. Chekan
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Mechanistic understanding of lanthipeptide biosynthetic enzymes
LM Repka, JR Chekan, SK Nair, WA Van Der Donk
Chemical reviews 117 (8), 5457-5520, 2017
4272017
Xylan utilization in human gut commensal bacteria is orchestrated by unique modular organization of polysaccharide-degrading enzymes
M Zhang, JR Chekan, D Dodd, PY Hong, L Radlinski, V Revindran, ...
Proceedings of the National Academy of Sciences 111 (35), E3708-E3717, 2014
1722014
Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom
JK Brunson, SMK McKinnie, JR Chekan, JP McCrow, ZD Miles, ...
Science 361 (6409), 1356-1358, 2018
1362018
Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis
KL Dunbar, JR Chekan, CL Cox, BJ Burkhart, SK Nair, DA Mitchell
Nature chemical biology 10 (10), 823-829, 2014
962014
Guanitoxin, re-naming a cyanobacterial organophosphate toxin
MF Fiore, ST de Lima, WW Carmichael, SMK McKinnie, JR Chekan, ...
Harmful Algae 92, 101737, 2020
742020
Genome mining methods to discover bioactive natural products
KD Bauman, KS Butler, BS Moore, JR Chekan
Natural Product Reports 38 (11), 2100-2129, 2021
732021
Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants
JR Chekan, P Estrada, PS Covello, SK Nair
Proceedings of the National Academy of Sciences 114 (25), 6551-6556, 2017
602017
Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid
JR Chekan, SMK McKinnie, ML Moore, SG Poplawski, TP Michael, ...
Angewandte Chemie 131 (25), 8542-8545, 2019
512019
Steric complementarity directs sequence promiscuous leader binding in RiPP biosynthesis
JR Chekan, C Ongpipattanakul, SK Nair
Proceedings of the National Academy of Sciences 116 (48), 24049-24055, 2019
432019
Biosynthesis of l‐4‐Chlorokynurenine, an Antidepressant Prodrug and a Non‐Proteinogenic Amino Acid Found in Lipopeptide Antibiotics
H Luhavaya, R Sigrist, JR Chekan, SMK McKinnie, BS Moore
Angewandte Chemie International Edition 58 (25), 8394-8399, 2019
402019
Molecular basis for resistance against phosphonate antibiotics and herbicides
JR Chekan, DP Cogan, SK Nair
MedChemComm 7 (1), 28-36, 2016
362016
Structure of the lasso peptide isopeptidase identifies a topology for processing threaded substrates
JR Chekan, JD Koos, C Zong, MO Maksimov, AJ Link, SK Nair
Journal of the American Chemical Society 138 (50), 16452-16458, 2016
352016
A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase
SC Peck, JR Chekan, EC Ulrich, SK Nair, WA Van Der Donk
Journal of the American Chemical Society 137 (9), 3217-3220, 2015
252015
Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation
V Agarwal, SC Peck, JH Chen, SA Borisova, JR Chekan, ...
Chemistry & biology 21 (1), 125-135, 2014
232014
Biosynthesis of guanitoxin enables global environmental detection in freshwater cyanobacteria
ST Lima, TR Fallon, JL Cordoza, JR Chekan, E Delbaje, AR Hopiavuori, ...
Journal of the American Chemical Society 144 (21), 9372-9379, 2022
222022
Biosynthesis of marine toxins
JR Chekan, TR Fallon, BS Moore
Current Opinion in Chemical Biology 59, 119-129, 2020
222020
Structural and biochemical basis for mannan utilization by Caldanaerobius polysaccharolyticus strain ATCC BAA-17
JR Chekan, IH Kwon, V Agarwal, D Dodd, V Revindran, RI Mackie, I Cann, ...
Journal of Biological Chemistry 289 (50), 34965-34977, 2014
192014
Molecular basis for enantioselective herbicide degradation imparted by aryloxyalkanoate dioxygenases in transgenic plants
JR Chekan, C Ongpipattanakul, TR Wright, B Zhang, JM Bollinger Jr, ...
Proceedings of the National Academy of Sciences 116 (27), 13299-13304, 2019
182019
Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads
P Olivares, EC Ulrich, JR Chekan, WA van der Donk, SK Nair
ACS Chemical Biology 12 (2), 456–463, 2017
182017
Domoic acid biosynthesis in the red alga Chondria armata suggests a complex evolutionary history for toxin production
TS Steele, JK Brunson, Y Maeno, R Terada, AE Allen, M Yotsu-Yamashita, ...
Proceedings of the National Academy of Sciences 119 (6), e2117407119, 2022
152022
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