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Leonard Freedman, Ph.D.
Leonard Freedman, Ph.D.
CSO, Frederick National Laboratory for Cancer Research
Verifierad e-postadress på nih.gov
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Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
BF Luisi, WX Xu, Z Otwinowski, LP Freedman, KR Yamamoto, PB Sigler
Nature 352 (6335), 497-505, 1991
19341991
Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937.
M Liu, MH Lee, M Cohen, M Bommakanti, LP Freedman
Genes & development 10 (2), 142-153, 1996
11071996
The economics of reproducibility in preclinical research
LP Freedman, IM Cockburn, TS Simcoe
PLoS biology 13 (6), e1002165, 2015
10802015
Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
C Rachez, BD Lemon, Z Suldan, V Bromleigh, M Gamble, AM Näär, ...
Nature 398 (6730), 824-828, 1999
8861999
Solution structure of the glucocorticoid receptor DNA-binding domain
T Härd, E Kellenbach, R Boelens, BA Maler, K Dahlman, LP Freedman, ...
Science 249 (4965), 157-160, 1990
7391990
The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain
LP Freedman, BF Luisi, ZR Korszun, R Basavappa, PB Sigler, ...
Nature 334 (6182), 543-546, 1988
6881988
Increasing the complexity of coactivation in nuclear receptor signaling
LP Freedman
Cell 97 (1), 5-8, 1999
5381999
Transcriptional Repression of the Interleukin-2 Gene by Vitamin D3: Direct Inhibition of NFATp/AP-1 Complex Formation by a Nuclear Hormone Receptor
I Alroy, TL Towers, LP Freedman
Molecular and cellular biology 15 (10), 5789-5799, 1995
5191995
A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system
C Rachez, Z Suldan, J Ward, CPB Chang, D Burakov, ...
Genes & development 12 (12), 1787-1800, 1998
5111998
Anatomy of the steroid receptor zinc finger region
LP Freedman
Endocrine reviews 13 (2), 129-145, 1992
4751992
Mechanisms of gene regulation by vitamin D3 receptor: a network of coactivator interactions
C Rachez, LP Freedman
Gene 246 (1-2), 9-21, 2000
4242000
Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival
SA Krum, GA Miranda‐Carboni, PV Hauschka, JS Carroll, TF Lane, ...
The EMBO journal 27 (3), 535-545, 2008
4142008
Transcriptional activation of the human p21WAF1/CIP1 gene by retinoic acid receptor: correlation with retinoid induction of U937 cell differentiation
M Liu, A Iavarone, LP Freedman
Journal of Biological Chemistry 271 (49), 31723-31728, 1996
3851996
Repression of transcription of the p27Kip1 cyclin-dependent kinase inhibitor gene by c-Myc
W Yang, J Shen, M Wu, M Arsura, M FitzGerald, Z Suldan, DW Kim, ...
Oncogene 20 (14), 1688-1702, 2001
3742001
1, 25-dihydroxyvitamin D3 inhibits IFN-γ and IL-4 levels during in vitro polarization of primary murine CD4+ T cells
TP Staeva-Vieira, LP Freedman
The Journal of Immunology 168 (3), 1181-1189, 2002
3682002
Differential regulation of glucocorticoid receptor transcriptional activation via AF‐1‐associated proteins
AB Hittelman, D Burakov, JA Iñiguez‐Lluhí, LP Freedman, MJ Garabedian
The EMBO journal, 1999
3641999
Mediator complexes and transcription
C Rachez, LP Freedman
Current opinion in cell biology 13 (3), 274-280, 2001
3572001
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II
HM Bourbon, A Aguilera, AZ Ansari, FJ Asturias, AJ Berk, S Bjorklund, ...
Molecular cell 14 (5), 553-557, 2004
3412004
Signaling by estrogens
BJ Cheskis, JG Greger, S Nagpal, LP Freedman
Journal of cellular physiology 213 (3), 610-617, 2007
2962007
Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities.
M Schena, LP Freedman, KR Yamamoto
Genes & development 3 (10), 1590-1601, 1989
2741989
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Artiklar 1–20