| Domain–domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel MA Zaydman, MA Kasimova, K McFarland, Z Beller, P Hou, HE Kinser, ... Elife 3, e03606, 2014 | 89 | 2014 |
| Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening P Hou, J Eldstrom, J Shi, L Zhong, K McFarland, Y Gao, D Fedida, J Cui Nature communications 8 (1), 1730, 2017 | 67 | 2017 |
| Predicting patient response to the antiarrhythmic mexiletine based on genetic variation: personalized medicine for long QT syndrome W Zhu, A Mazzanti, TL Voelker, P Hou, JD Moreno, P Angsutararux, ... Circulation research 124 (4), 539-552, 2019 | 57 | 2019 |
| Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation P Hou, PW Kang, AD Kongmeneck, ND Yang, Y Liu, J Shi, X Xu, ... Nature communications 11 (1), 676, 2020 | 49 | 2020 |
| TRPV1 channels are functionally coupled with BK (mSlo1) channels in rat dorsal root ganglion (DRG) neurons Y Wu, Y Liu, P Hou, Z Yan, W Kong, B Liu, X Li, J Yao, Y Zhang, F Qin, ... PloS one 8 (10), e78203, 2013 | 48 | 2013 |
| Physiological role of Kv1. 3 channel in T lymphocyte cell investigated quantitatively by kinetic modeling P Hou, R Zhang, Y Liu, J Feng, W Wang, Y Wu, J Ding PLoS One 9 (3), e89975, 2014 | 39 | 2014 |
| Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state KC Taylor, PW Kang, P Hou, ND Yang, G Kuenze, JA Smith, J Shi, ... Elife 9, e53901, 2020 | 37 | 2020 |
| ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling P Hou, J Shi, KMF White, Y Gao, J Cui Elife 8, e48576, 2019 | 35 | 2019 |
| Human β-Defensin 2 Is a Novel Opener of Ca2+-Activated Potassium Channels and Induces Vasodilation and Hypotension in Monkeys R Liu, Z Zhang, H Liu, P Hou, J Lang, S Wang, H Yan, P Li, Z Huang, ... Hypertension 62 (2), 415-425, 2013 | 33 | 2013 |
| Inter-α/β subunits coupling mediating pre-inactivation and augmented activation of BKCa(β2) P Hou, W Zeng, G Gan, C Lv, X Guo, Z Zhang, H Liu, Y Wu, J Yao, AD Wei, ... Scientific reports 3 (1), 1666, 2013 | 33 | 2013 |
| A PIP2 substitute mediates voltage sensor-pore coupling in KCNQ activation Y Liu, X Xu, J Gao, MM Naffaa, H Liang, J Shi, HZ Wang, ND Yang, P Hou, ... Communications biology 3 (1), 385, 2020 | 25 | 2020 |
| Structural basis for calcium and magnesium regulation of a large conductance calcium-activated potassium channel with β1 subunits HW Liu, PP Hou, XY Guo, ZW Zhao, B Hu, X Li, LY Wang, JP Ding, ... Journal of Biological Chemistry 289 (24), 16914-16923, 2014 | 23 | 2014 |
| Structural mechanisms for the activation of human cardiac KCNQ1 channel by electro-mechanical coupling enhancers D Ma, L Zhong, Z Yan, J Yao, Y Zhang, F Ye, Y Huang, D Lai, W Yang, ... Proceedings of the National Academy of Sciences 119 (45), e2207067119, 2022 | 12 | 2022 |
| Extrapolating microdomain Ca2+ dynamics using BK channels as a Ca2+ sensor P Hou, F Xiao, H Liu, M Yuchi, G Zhang, Y Wu, W Wang, W Zeng, M Ding, ... Scientific reports 6 (1), 17343, 2016 | 9 | 2016 |
| A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling JA Schreiber, M Möller, M Zaydman, L Zhao, Z Beller, S Becker, N Ritter, ... Communications Biology 5 (1), 301, 2022 | 8 | 2022 |
| Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects Y Lin, SZ Grinter, Z Lu, X Xu, HZ Wang, H Liang, P Hou, J Gao, C Clausen, ... Proceedings of the National Academy of Sciences 118 (20), e2024215118, 2021 | 6 | 2021 |
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| Chinese herbal medicine for the treatment of cardiovascular diseases─ targeting cardiac ion channels Z Yan, L Zhong, W Zhu, SK Chung, P Hou Pharmacological Research, 106765, 2023 | 4 | 2023 |
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| Single Channel Recordings Reveal Differential β2 Subunit Modulations Between Mammalian and Drosophila BKCa(β2) Channels Z Yan, B Hu, Z Huang, L Zhong, X Guo, A Weng, F Xiao, W Zeng, Y Zhang, ... Plos one 11 (10), e0163308, 2016 | 2 | 2016 |
Mark ZaydmanAssistant Professor, Washington University School of MedicineVerified email at wusm.wustl.edu
