| Therapeutic target database update 2016: enriched resource for bench to clinical drug target and targeted pathway information H Yang, C Qin, YH Li, L Tao, J Zhou, CY Yu, F Xu, Z Chen, F Zhu, ... Nucleic acids research 44 (D1), D1069-D1074, 2016 | 283 | 2016 |
| Clinical trials, progression-speed differentiating features and swiftness rule of the innovative targets of first-in-class drugs YH Li, XX Li, JJ Hong, YX Wang, JB Fu, H Yang, CY Yu, FC Li, J Hu, ... Briefings in Bioinformatics 21 (2), 649-662, 2020 | 149 | 2020 |
| Combined metabolic activators accelerates recovery in mild‐to‐moderate COVID‐19 O Altay, M Arif, X Li, H Yang, M Aydın, G Alkurt, W Kim, D Akyol, C Zhang, ... Advanced Science 8 (17), 2101222, 2021 | 72 | 2021 |
| The human kinome targeted by FDA approved multi-target drugs and combination products: A comparative study from the drug-target interaction network perspective YH Li, PP Wang, XX Li, CY Yu, H Yang, J Zhou, WW Xue, J Tan, F Zhu PloS one 11 (11), e0165737, 2016 | 68 | 2016 |
| Comparison of FDA approved kinase targets to clinical trial ones: insights from their system profiles and drug-target interaction networks J Xu, P Wang, H Yang, J Zhou, Y Li, X Li, W Xue, C Yu, Y Tian, F Zhu BioMed Research International 2016, 2016 | 45 | 2016 |
| Assessing the performances of protein function prediction algorithms from the perspectives of identification accuracy and false discovery rate CY Yu, XX Li, H Yang, YH Li, WW Xue, YZ Chen, L Tao, F Zhu International journal of molecular sciences 19 (1), 183, 2018 | 38 | 2018 |
| Identification of dual active agents targeting 5-HT1A and SERT by combinatorial virtual screening methods P Wang, F Yang, H Yang, X Xu, D Liu, W Xue, F Zhu Bio-Medical Materials and Engineering 26 (s1), S2233-S2239, 2015 | 31 | 2015 |
| Multiomics analysis reveals the impact of microbiota on host metabolism in hepatic steatosis M Zeybel, M Arif, X Li, O Altay, H Yang, M Shi, M Akyildiz, B Saglam, ... Advanced Science 9 (11), 2104373, 2022 | 30 | 2022 |
| BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH RK Baboota, A Rawshani, L Bonnet, X Li, H Yang, A Mardinoglu, ... Nature Metabolism 4 (8), 1007-1021, 2022 | 28 | 2022 |
| Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients M Zeybel, O Altay, M Arif, X Li, H Yang, C Fredolini, M Akyildiz, B Saglam, ... Molecular systems biology 17 (10), e10459, 2021 | 27 | 2021 |
| Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients: a randomised, double-blinded, placebo-controlled phase-II trial B Yulug, O Altay, X Li, L Hanoglu, S Cankaya, S Lam, HA Velioglu, ... Translational Neurodegeneration 12 (1), 4, 2023 | 21 | 2023 |
| Multi-omics personalized network analyses highlight progressive disruption of central metabolism associated with COVID-19 severity AT Ambikan, H Yang, S Krishnan, SS Akusjärvi, S Gupta, M Lourda, ... Cell systems 13 (8), 665-681. e4, 2022 | 21 | 2022 |
| Chronic hyperinsulinemia promotes human hepatocyte senescence RK Baboota, R Spinelli, MC Erlandsson, BB Brandao, M Lino, H Yang, ... Molecular Metabolism 64, 101558, 2022 | 19 | 2022 |
| A network-based approach reveals the dysregulated transcriptional regulation in non-alcoholic fatty liver disease H Yang, M Arif, M Yuan, X Li, K Shong, H Türkez, J Nielsen, M Uhlén, ... Iscience 24 (11), 2021 | 15 | 2021 |
| Prediction of drug candidates for clear cell renal cell carcinoma using a systems biology-based drug repositioning approach X Li, K Shong, W Kim, M Yuan, H Yang, Y Sato, H Kume, S Ogawa, ... EBioMedicine 78, 2022 | 12 | 2022 |
| Discovery of therapeutic agents targeting PKLR for NAFLD using drug repositioning C Zhang, M Shi, W Kim, M Arif, M Klevstig, X Li, H Yang, C Bayram, I Bolat, ... EBioMedicine 83, 2022 | 11 | 2022 |
| A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis Q Pan, G Luo, J Qu, S Chen, X Zhang, N Zhao, J Ding, H Yang, M Li, L Li, ... EMBO Molecular Medicine 13 (11), e14563, 2021 | 11 | 2021 |
| Combined metabolic activators decrease liver steatosis by activating mitochondrial metabolism in hamsters fed with a high-fat diet H Yang, J Mayneris-Perxachs, N Boqué, JM Del Bas, L Arola, M Yuan, ... Biomedicines 9 (10), 1440, 2021 | 10 | 2021 |
| Ellagic acid and its metabolites as potent and selective allosteric inhibitors of liver pyruvate kinase UM Battisti, C Gao, F Akladios, W Kim, H Yang, C Bayram, I Bolat, ... Nutrients 15 (3), 577, 2023 | 8 | 2023 |
| Systematic transcriptional analysis of human cell lines for gene expression landscape and tumor representation H Jin, C Zhang, M Zwahlen, K Von Feilitzen, M Karlsson, M Shi, M Yuan, ... Nature Communications 14 (1), 5417, 2023 | 5 | 2023 |
