The promise and peril of chemical probes CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ... Nature chemical biology 11 (8), 536-541, 2015 | 835 | 2015 |
The quantum mechanical tunnelling time problem-revisited S Collins, D Lowe, JR Barker Journal of Physics C: Solid State Physics 20 (36), 6213, 1987 | 216 | 1987 |
Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity J Rudolph, WP Esler, S O'connor, PDG Coish, PL Wickens, M Brands, ... Journal of medicinal chemistry 50 (21), 5202-5216, 2007 | 186 | 2007 |
LINGO-1, a transmembrane signaling protein, inhibits oligodendrocyte differentiation and myelination through intercellular self-interactions S Jepson, B Vought, CH Gross, L Gan, D Austen, JD Frantz, J Zwahlen, ... Journal of Biological Chemistry 287 (26), 22184-22195, 2012 | 136 | 2012 |
Muscarinic antagonists D Lowe, W Chang, J Kozlowski, JG Berger, R McQuade, A Barnett, ... US Patent 5,883,096, 1999 | 124 | 1999 |
Muscarinic antagonists for treating memory loss T Asberom, DB Lowe, MJ Green US Patent 5,952,349, 1999 | 107 | 1999 |
Pyrrolo [2, 1-f][1, 2, 4] triazin-4-ylamines IGF-1R kinase inhibitors for the treatment of cancer and other hyperproliferative diseases S O'connor, J Dumas, W Lee, J Dixon, D Cantin, D Gunn, J Burke, ... US Patent 8,431,695, 2013 | 105 | 2013 |
Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose TH Claus, DB Lowe, Y Liang, AI Salhanick, CK Lubeski, L Yang, ... Journal of Pharmacology and Experimental Therapeutics 315 (3), 1396-1402, 2005 | 105 | 2005 |
A dynamic analysis of resonant tunnelling S Collins, D Lowe, JR Barker Journal of Physics C: Solid State Physics 20 (36), 6233, 1987 | 97 | 1987 |
SCH 57790, a selective muscarinic M2 receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals GJ Carey, W Billard, H Binch III, M Cohen-Williams, G Crosby, M Grzelak, ... European journal of pharmacology 431 (2), 189-200, 2001 | 86 | 2001 |
Muscarinic agonists and antagonists in the treatment of Alzheimer's disease W Greenlee, J Clader, T Asberom, S McCombie, J Ford, H Guzik, ... Il Farmaco 56 (4), 247-250, 2001 | 86 | 2001 |
In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase DB Lowe, S Magnuson, N Qi, AM Campbell, J Cook, Z Hong, M Wang, ... Bioorganic & medicinal chemistry letters 14 (12), 3155-3159, 2004 | 73 | 2004 |
Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR-γ binding agents A Stolle, JP Dumas, W Carley, PDG Coish, SR Magnuson, Y Wang, ... US Patent 6,787,651, 2004 | 57 | 2004 |
Muscarinic antagonists JA Kozlowski, DB Lowe, WK Chang, S Dugar US Patent 5,935,958, 1999 | 44 | 1999 |
Design and synthesis of a novel series of orally bioavailable, CNS-penetrant, isoform selective phosphoinositide 3-kinase γ (PI3Kγ) inhibitors with potential for the treatment … JH Come, PN Collier, JA Henderson, AC Pierce, RJ Davies, A Le Tiran, ... Journal of Medicinal Chemistry 61 (12), 5245-5256, 2018 | 40 | 2018 |
4, 5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 2. SAR D Gunn, C Akuche, J Baryza, ML Blue, C Brennan, AM Campbell, S Choi, ... Bioorganic & medicinal chemistry letters 15 (12), 3053-3057, 2005 | 38 | 2005 |
4, 5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate J Wood, CM Bagi, C Akuche, A Bacchiocchi, J Baryza, ML Blue, ... Bioorganic & medicinal chemistry letters 16 (18), 4965-4968, 2006 | 35 | 2006 |
A model study of field-dependent dynamical screening due to mobile electrons in submicron semiconductor devices D Lowe, JR Barker Journal of Physics C: Solid State Physics 18 (12), 2507, 1985 | 34 | 1985 |
17-beta-hydroxysteroid dehydrogenase-II inhibitors JE Wood, JL Baryza, CR Brennan, S Choi, JH Cook, BR Dixon, PP Ehrlich, ... US Patent 6,784,167, 2004 | 31 | 2004 |
SCH 57790: a novel M2 receptor selective antagonist JE Lachowicz, D Lowe, RA Duffy, V Ruperto, LA Taylor, H Guzik, J Brown, ... Life sciences 64 (6-7), 535-539, 1999 | 31 | 1999 |