| Giving drugs a second chance: overcoming regulatory and financial hurdles in repurposing approved drugs as cancer therapeutics JJ Hernandez, M Pryszlak, L Smith, C Yanchus, N Kurji, VM Shahani, ... Frontiers in oncology 7, 273, 2017 | 247 | 2017 |
| Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein S Fletcher, JA Drewry, VM Shahani, BDG Page, PT Gunning Biochemistry and Cell Biology 87 (6), 825-833, 2009 | 132 | 2009 |
| Potent targeting of the STAT3 protein in brain cancer stem cells: a promising route for treating glioblastoma S Haftchenary, HA Luchman, AO Jouk, AJ Veloso, BDG Page, XR Cheng, ... ACS medicinal chemistry letters 4 (11), 1102-1107, 2013 | 122 | 2013 |
| Disruption of Transcriptionally Active Stat3 Dimers with Non‐phosphorylated, Salicylic Acid‐Based Small Molecules: Potent in vitro and Tumor Cell Activities S Fletcher, J Singh, X Zhang, P Yue, BDG Page, S Sharmeen, ... ChemBioChem 10 (12), 1959-1964, 2009 | 121 | 2009 |
| Concise access to N9-mono-, N2-mono-and N2, N9-di-substituted guanines via efficient Mitsunobu reactions S Fletcher, VM Shahani, AJ Lough, PT Gunning Tetrahedron 66 (25), 4621-4632, 2010 | 57 | 2010 |
| Comprehensive mapping of Cystic Fibrosis mutations to CFTR protein identifies mutation clusters and molecular docking predicts corrector binding site SV Molinski, VM Shahani, AS Subramanian, SS MacKinnon, G Woollard, ... Proteins: Structure, Function, and Bioinformatics, 2018 | 51 | 2018 |
| Facile and efficient access to 2, 6, 9-tri-substituted purines through sequential N9, N2 Mitsunobu reactions S Fletcher, VM Shahani, PT Gunning Tetrahedron letters 50 (29), 4258-4261, 2009 | 49 | 2009 |
| Identification of NAE inhibitors exhibiting potent activity in leukemia cells: exploring the structural determinants of NAE specificity JL Lukkarila, SR da Silva, M Ali, VM Shahani, GW Xu, J Berman, ... ACS medicinal chemistry letters 2 (8), 577-582, 2011 | 48 | 2011 |
| Identification of purine-scaffold small-molecule inhibitors of Stat3 activation by QSAR studies VM Shahani, P Yue, S Haftchenary, W Zhao, JL Lukkarila, X Zhang, D Ball, ... ACS medicinal chemistry letters 2 (1), 79-84, 2010 | 47 | 2010 |
| Design, synthesis, and in vitro characterization of novel hybrid peptidomimetic inhibitors of STAT3 protein VM Shahani, P Yue, S Fletcher, S Sharmeen, MA Sukhai, DP Luu, ... Bioorganic & medicinal chemistry 19 (5), 1823-1838, 2011 | 44 | 2011 |
| Genetic Variability of the SARS-CoV-2 Pocketome S Yazdani, N De Maio, Y Ding, V Shahani, N Goldman, M Schapira Journal of Proteome Research, 2021 | 25 | 2021 |
| PolypharmDB, a deep learning-based resource, quickly identifies repurposed drug candidates for COVID-19 SR Dar'ya, SS MacKinnon, M Landon, A Windemuth, N Kurji, V Shahani | 22 | 2020 |
| Computational proteome-wide screening predicts neurotoxic drug-protein interactome for the investigational analgesic BIA 10-2474 SV Molinski, VM Shahani, SS MacKinnon, LD Morayniss, M Laforet, ... Biochemical and biophysical research communications 483 (1), 502-508, 2017 | 19 | 2017 |
| A 2, 6, 9-hetero-trisubstituted purine inhibitor exhibits potent biological effects against multiple myeloma cells VM Shahani, DP Ball, AV Ramos, Z Li, PA Spagnuolo, S Haftchenary, ... Bioorganic & medicinal chemistry 21 (17), 5618-5628, 2013 | 16 | 2013 |
| The efficacy of interactive analogical models in the instruction of bond energy curves in undergraduate chemistry VM Shahani, J Jenkinson Chemistry Education Research and Practice 17 (2), 417-428, 2016 | 15 | 2016 |
| Assessing methods and obstacles in chemical space exploration S Reeves, B DiFrancesco, V Shahani, S MacKinnon, A Windemuth, ... Applied AI Letters 1 (2), e17, 2020 | 13 | 2020 |
| Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease M Sugiyama, H Cui, SR Dar'ya, M Karimzadeh, E Rujas, H Maan, S Hayat, ... bioRxiv, 2021 | 12 | 2021 |
| Predicting drug properties with parameter-free machine learning: pareto-optimal embedded modeling (POEM) AE Brereton, S MacKinnon, Z Safikhani, S Reeves, S Alwash, V Shahani, ... Machine Learning: Science and Technology 1 (2), 025008, 2020 | 11 | 2020 |
| Identification of a potent salicylic acid-based inhibitor of tyrosine phosphatase PTP1B S Haftchenary, DP Ball, I Aubry, M Landry, VM Shahani, S Fletcher, ... MedChemComm 4 (6), 987-992, 2013 | 10 | 2013 |
| Electrochemical detection of the Fc-STAT3 phosphorylation and STAT3–Fc-STAT3 dimerization and inhibition S Martic, MK Rains, S Haftchenary, VM Shahani, D Kraskouskaya, ... Molecular BioSystems 10 (3), 576-580, 2014 | 7 | 2014 |
