Patrick T. Gunning
Patrick T. Gunning
Canada Research Chair and Associate Professor of Chemistry
Verified email at utoronto.ca
TitleCited byYear
Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts
X Zhang, P Yue, BDG Page, T Li, W Zhao, AT Namanja, D Paladino, ...
Proceedings of the National Academy of Sciences 109 (24), 9623-9628, 2012
2462012
An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects
KAZ Siddiquee, PT Gunning, M Glenn, WP Katt, S Zhang, C Schroeck, ...
ACS chemical biology 2 (12), 787-798, 2007
1842007
A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes
X Zhang, P Yue, S Fletcher, W Zhao, PT Gunning, J Turkson
Biochemical pharmacology 79 (10), 1398-1409, 2010
1552010
Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein
S Fletcher, J Turkson, PT Gunning
ChemMedChem: Chemistry Enabling Drug Discovery 3 (8), 1159-1168, 2008
1282008
Recent advances in biosensory and medicinal therapeutic applications of zinc (II) and copper (II) coordination complexes
JA Drewry, PT Gunning
Coordination Chemistry Reviews 255 (3-4), 459-472, 2011
1242011
UBA5 inhibitors
PT Gunning, SR Da Silva, SL Paiva, JL Lukkarila
US Patent App. 10/077,284, 2018
1152018
Signal transducer and activator of transcription 3 inhibitors: a patent review
BDG Page, DP Ball, PT Gunning
Expert opinion on therapeutic patents 21 (1), 65-83, 2011
1112011
Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein
S Fletcher, JA Drewry, VM Shahani, BDG Page, PT Gunning
Biochemistry and Cell Biology 87 (6), 825-833, 2009
1072009
Disruption of Transcriptionally Active Stat3 Dimers with Non‐phosphorylated, Salicylic Acid‐Based Small Molecules: Potent in vitro and Tumor Cell Activities
S Fletcher, J Singh, X Zhang, P Yue, BDG Page, S Sharmeen, ...
ChemBioChem 10 (12), 1959-1964, 2009
962009
Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia
AM Eiring, BDG Page, IL Kraft, CC Mason, NA Vellore, D Resetca, ...
Leukemia 29 (3), 586, 2015
892015
Progress towards the development of SH2 domain inhibitors
D Kraskouskaya, E Duodu, CC Arpin, PT Gunning
Chemical Society reviews 42 (8), 3337-3370, 2013
812013
Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity
BDG Page, H Khoury, RC Laister, S Fletcher, M Vellozo, A Manzoli, P Yue, ...
Journal of medicinal chemistry 55 (3), 1047-1055, 2012
782012
Potent targeting of the STAT3 protein in brain cancer stem cells: a promising route for treating glioblastoma
S Haftchenary, HA Luchman, AO Jouk, AJ Veloso, BDG Page, XR Cheng, ...
ACS medicinal chemistry letters 4 (11), 1102-1107, 2013
772013
Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains
PT Gunning, WP Katt, M Glenn, K Siddique, JS Kim, R Jove, SM Sebti, ...
Bioorganic & medicinal chemistry letters 17 (7), 1875-1878, 2007
732007
Inhibiting aberrant Stat3 function with molecular therapeutics: a progress report
S Haftchenary, M Avadisian, PT Gunning
Anti-cancer drugs 22 (2), 115-127, 2011
712011
Substituted 2-hydroxy-4-(2-(phenylsulfonamido) acetamido) benzoic acid analogs as inhibitors of STAT protein
J Turkson, P Gunning
US Patent 10,196,373, 2019
612019
STAT5 is a key regulator in NK cells and acts as a molecular switch from tumor surveillance to tumor promotion
D Gotthardt, EM Putz, E Grundschober, M Prchal-Murphy, E Straka, ...
Cancer discovery 6 (4), 414-429, 2016
602016
An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery
RN Mitra, M Doshi, X Zhang, JC Tyus, N Bengtsson, S Fletcher, ...
Biomaterials 33 (5), 1500-1508, 2012
602012
Mild, efficient and rapid O-debenzylation of ortho-substituted phenols with trifluoroacetic acid
S Fletcher, PT Gunning
Tetrahedron Letters 49 (33), 4817-4819, 2008
592008
Targeting Protein–Protein Interactions: Suppression of Stat3 Dimerization with Rationally Designed Small‐Molecule, Nonpeptidic SH2 Domain Binders
PT Gunning, MP Glenn, KAZ Siddiquee, WP Katt, E Masson, SM Sebti, ...
ChemBioChem 9 (17), 2800-2803, 2008
582008
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