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Joachim Almquist
Joachim Almquist
Director Clinical Pharmacology and Pharmacometrics at AstraZeneca
Verifierad e-postadress på astrazeneca.com
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Kinetic models in industrial biotechnology–improving cell factory performance
J Almquist, M Cvijovic, V Hatzimanikatis, J Nielsen, M Jirstrand
Metabolic engineering 24, 38-60, 2014
3262014
Bridging the gaps in systems biology
M Cvijovic, J Almquist, J Hagmar, S Hohmann, HM Kaltenbach, E Klipp, ...
Molecular Genetics and Genomics 289, 727-734, 2014
602014
Yeast AMP-activated protein kinase monitors glucose concentration changes and absolute glucose levels
L Bendrioua, M Smedh, J Almquist, M Cvijovic, M Jirstrand, M Goksör, ...
Journal of Biological Chemistry 289 (18), 12863-12875, 2014
492014
Mixed effects modeling using stochastic differential equations: illustrated by pharmacokinetic data of nicotinic acid in obese Zucker rats
J Leander, J Almquist, C Ahlström, J Gabrielsson, M Jirstrand
The AAPS journal 17, 586-596, 2015
462015
Using sensitivity equations for computing gradients of the FOCE and FOCEI approximations to the population likelihood
J Almquist, J Leander, M Jirstrand
Journal of pharmacokinetics and pharmacodynamics 42, 191-209, 2015
422015
A nonlinear mixed effects approach for modeling the cell-to-cell variability of Mig1 dynamics in yeast
J Almquist, L Bendrioua, CB Adiels, M Goksör, S Hohmann, M Jirstrand
PLoS One 10 (4), e0124050, 2015
382015
Hemostatic effects of the ticagrelor antidote MEDI2452 in pigs treated with ticagrelor on a background of aspirin
S Pehrsson, KJ Johansson, A Janefeldt, AS Sandinge, S Maqbool, ...
Journal of Thrombosis and Haemostasis 15 (6), 1213-1222, 2017
282017
A phase 2a, double-blind, placebo-controlled randomized trial of inhaled TLR9 agonist AZD1419 in asthma
I Psallidas, V Backer, P Kuna, R Palmér, S Necander, M Aurell, ...
American Journal of Respiratory and Critical Care Medicine 203 (3), 296-306, 2021
222021
Tumor static concentration curves in combination therapy
T Cardilin, J Almquist, M Jirstrand, A Sostelly, C Amendt, S El Bawab, ...
The AAPS journal 19, 456-467, 2017
202017
A kinetic model of the monocarboxylate transporter MCT1 and its interaction with carbonic anhydrase II
J Almquist, P Lang, D Prätzel-Wolters, J Deitmer, M Jirstrand, H Becker
202010
Model‐based evaluation of radiation and radiosensitizing agents in oncology
T Cardilin, J Almquist, M Jirstrand, A Zimmermann, S El Bawab, ...
CPT: Pharmacometrics & Systems Pharmacology 7 (1), 51-58, 2018
182018
Effects of a selective glucocorticoid receptor modulator (AZD9567) versus prednisolone in healthy volunteers: two phase 1, single-blind, randomised controlled trials
TH Myrbäck, S Prothon, K Edman, J Leander, M Hashemi, M Dearman, ...
The Lancet Rheumatology 2 (1), e31-e41, 2020
162020
Unraveling the pharmacokinetic interaction of ticagrelor and MEDI2452 (Ticagrelor antidote) by mathematical modeling
J Almquist, M Penney, S Pehrsson, AS Sandinge, A Janefeldt, S Maqbool, ...
CPT: Pharmacometrics & Systems Pharmacology 5 (6), 313-323, 2016
142016
Modeling of free fatty acid dynamics: insulin and nicotinic acid resistance under acute and chronic treatments
R Andersson, T Kroon, J Almquist, M Jirstrand, ND Oakes, ND Evans, ...
Journal of Pharmacokinetics and Pharmacodynamics 44 (3), 203-222, 2017
132017
Modeling the effect of Kv1. 5 block on the canine action potential
J Almquist, M Wallman, I Jacobson, M Jirstrand
Biophysical Journal 99 (9), 2726-2736, 2010
132010
Modeling long-term tumor growth and kill after combinations of radiation and radiosensitizing agents
T Cardilin, J Almquist, M Jirstrand, A Zimmermann, F Lignet, S El Bawab, ...
Cancer chemotherapy and pharmacology 83, 1159-1173, 2019
122019
Nonlinear mixed effects modeling of deterministic and stochastic dynamical systems in Wolfram Mathematica
J Leander, J Almquist, A Johnning, J Larsson, M Jirstrand
IFAC-PapersOnLine 54 (7), 409-414, 2021
112021
Joint feedback analysis modeling of nonesterified fatty acids in obese Zucker rats and normal Sprague–Dawley rats after different routes of administration of nicotinic acid
S Tapani, J Almquist, J Leander, C Ahlström, LA Peletier, M Jirstrand, ...
Journal of Pharmaceutical Sciences 103 (8), 2571-2584, 2014
112014
Exact gradients improve parameter estimation in nonlinear mixed effects models with stochastic dynamics
HK Olafsdottir, J Leander, J Almquist, M Jirstrand
The AAPS journal 20, 1-13, 2018
92018
Estimation of equipotent doses for anti‐inflammatory effects of prednisolone and AZD9567, an oral selective nonsteroidal glucocorticoid receptor modulator
J Almquist, MW Sadiq, UG Eriksson, T Hegelund Myrbäck, S Prothon, ...
CPT: Pharmacometrics & Systems Pharmacology 9 (8), 444-455, 2020
62020
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