| Protease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta K Bourd‐Boittin, D Bonnier, A Leyme, B Mari, P Tuffery, M Samson, ... Hepatology 54 (6), 2173-2184, 2011 | 99 | 2011 |
| Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration–proliferation dichotomy D Bhandari, I Lopez-Sanchez, A To, IC Lo, N Aznar, A Leyme, V Gupta, ... Proceedings of the National Academy of Sciences 112 (35), E4874-E4883, 2015 | 65 | 2015 |
| The disintegrin and metalloprotease ADAM12 is associated with TGF-β-induced epithelial to mesenchymal transition M Ruff, A Leyme, F Le Cann, D Bonnier, J Le Seyec, F Chesnel, L Fattet, ... PLoS One 10 (9), e0139179, 2015 | 62 | 2015 |
| Revealing the activity of trimeric G-proteins in live cells with a versatile biosensor design M Maziarz, JC Park, A Leyme, A Marivin, A Garcia-Lopez, PP Patel, ... Cell 182 (3), 770-785. e16, 2020 | 60 | 2020 |
| Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-binding and activating motif AI de Opakua, K Parag-Sharma, V DiGiacomo, N Merino, A Leyme, ... Nature communications 8 (1), 15163, 2017 | 46 | 2017 |
| Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin A Leyme, A Marivin, L Perez-Gutierrez, LT Nguyen, M Garcia-Marcos Journal of Cell Biology 210 (7), 1165-1184, 2015 | 46 | 2015 |
| GIV/Girdin activates Gαi and inhibits Gαs via the same motif V Gupta, D Bhandari, A Leyme, N Aznar, KK Midde, IC Lo, J Ear, ... Proceedings of the National Academy of Sciences 113 (39), E5721-E5730, 2016 | 38 | 2016 |
| Dominant-negative Gα subunits are a mechanism of dysregulated heterotrimeric G protein signaling in human disease A Marivin, A Leyme, K Parag-Sharma, V DiGiacomo, AY Cheung, ... Science signaling 9 (423), ra37-ra37, 2016 | 32 | 2016 |
| Atypical activation of the G protein Gαq by the oncogenic mutation Q209P M Maziarz, A Leyme, A Marivin, A Luebbers, PP Patel, Z Chen, ... Journal of Biological Chemistry 293 (51), 19586-19599, 2018 | 31 | 2018 |
| Identification of ILK as a new partner of the ADAM12 disintegrin and metalloprotease in cell adhesion and survival A Leyme, K Bourd-Boittin, D Bonnier, A Falconer, Y Arlot-Bonnemains, ... Molecular biology of the cell 23 (17), 3461-3472, 2012 | 25 | 2012 |
| Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein A Leyme, A Marivin, M Maziarz, V DiGiacomo, MP Papakonstantinou, ... Proceedings of the National Academy of Sciences 114 (48), E10319-E10328, 2017 | 24 | 2017 |
| GIV/Girdin (Gα-interacting, vesicle-associated protein/Girdin) creates a positive feedback loop that potentiates outside-in integrin signaling in cancer cells A Leyme, A Marivin, M Garcia-Marcos Journal of Biological Chemistry 291 (15), 8269-8282, 2016 | 23 | 2016 |
| Cell‐surface metalloprotease ADAM12 is internalized by a clathrin‐and Grb2‐dependent mechanism D Stautz, A Leyme, MV Grandal, R Albrechtsen, B van Deurs, U Wewer, ... Traffic 13 (11), 1532-1546, 2012 | 23 | 2012 |
| GPCR-independent activation of G proteins promotes apical cell constriction in vivo A Marivin, V Morozova, I Walawalkar, A Leyme, DA Kretov, D Cifuentes, ... Journal of cell biology 218 (5), 1743-1763, 2019 | 20 | 2019 |
| Membrane recruitment of the non-receptor protein GIV/girdin (Gα-interacting, vesicle-associated protein/girdin) is sufficient for activating heterotrimeric G protein signaling K Parag-Sharma, A Leyme, V DiGiacomo, A Marivin, S Broselid, ... Journal of Biological Chemistry 291 (53), 27098-27111, 2016 | 19 | 2016 |
| Different biochemical properties explain why two equivalent Gα subunit mutants cause unrelated diseases A Leyme, A Marivin, J Casler, LT Nguyen, M Garcia-Marcos Journal of Biological Chemistry 289 (32), 21818-21827, 2014 | 15 | 2014 |
| GIV/Girdin creates a positive feedback loop that potentiates outside-in integrin signaling in cancer cells A Leyme, A Marivin, M Garcia-Marcos J Biol Chem 291, 8269-8282, 2016 | 5 | 2016 |
| A novel BRET biosensor for Gαq‐GTP reveals unique properties of cancer‐associated GNAQ mutants M Garcia‐Marcos, M Maziarz, A Leyme The FASEB Journal 32, 557.3-557.3, 2018 | 1 | 2018 |
| Profiling Gαq Cancer Mutations Using a Novel BRET‐based Biosensor M Maziarz, A Leyme, PP Patel, M Garcia‐Marcos The FASEB Journal 33 (S1), 668.8-668.8, 2019 | | 2019 |
| DAPLE links heterotrimeric G proteins to Wnt signaling during vertebrate development A Marvin, V DiGiacomo, A Leyme, M Garcia‐Marcos The FASEB Journal 31, 619.3-619.3, 2017 | | 2017 |
