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Charles Leitao
Charles Leitao
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Optimization of HER3 expression imaging using affibody molecules: Influence of chelator for labeling with indium-111
SS Rinne, CD Leitao, B Mitran, TZ Bass, KG Andersson, V Tolmachev, ...
Scientific reports 9 (1), 655, 2019
252019
Influence of molecular design on the targeting properties of ABD-fused mono-and bi-valent anti-HER3 affibody therapeutic constructs
M Altai, CD Leitao, SS Rinne, A Vorobyeva, C Atterby, S Ståhl, ...
Cells 7 (10), 164, 2018
242018
Molecular Design of HER3-Targeting Affibody Molecules: Influence of Chelator and Presence of HEHEHE-Tag on Biodistribution of 68Ga-Labeled Tracers
C Dahlsson Leitao, SS Rinne, B Mitran, A Vorobyeva, KG Andersson, ...
International Journal of Molecular Sciences 20 (5), 1080, 2019
232019
Evaluation of the therapeutic potential of a HER3-binding affibody construct TAM-HER3 in comparison with a monoclonal antibody, seribantumab
A Orlova, TZ Bass, SS Rinne, CD Leitao, M Rosestedt, C Atterby, ...
Molecular Pharmaceutics 15 (8), 3394-3403, 2018
222018
Comparative evaluation of affibody-and antibody fragments-based CAIX imaging probes in mice bearing renal cell carcinoma xenografts
J Garousi, FJ Huizing, A Vorobyeva, B Mitran, KG Andersson, CD Leitao, ...
Scientific Reports 9 (1), 14907, 2019
172019
Increase in negative charge of 68Ga/chelator complex reduces unspecific hepatic uptake but does not improve imaging properties of HER3-targeting affibody …
SS Rinne, C Dahlsson Leitao, J Gentry, B Mitran, A Abouzayed, ...
Scientific Reports 9 (1), 17710, 2019
162019
Evaluating the therapeutic efficacy of mono-and bivalent affibody-based fusion proteins targeting HER3 in a pancreatic cancer xenograft model
C Dahlsson Leitao, S S. Rinne, M Altai, O Vorontsova, F Dunås, ...
Pharmaceutics 12 (6), 551, 2020
112020
Benefit of later-time-point PET imaging of HER3 expression using optimized radiocobalt-labeled affibody molecules
SS Rinne, C Dahlsson Leitao, Z Saleh-Nihad, B Mitran, V Tolmachev, ...
International Journal of Molecular Sciences 21 (6), 1972, 2020
92020
Influence of residualizing properties of the radiolabel on radionuclide molecular imaging of HER3 using affibody molecules
SS Rinne, T Xu, C Dahlsson Leitao, S Ståhl, J Löfblom, A Orlova, ...
International Journal of Molecular Sciences 21 (4), 1312, 2020
92020
Improved contrast of affibody-mediated imaging of HER3 expression in mouse xenograft model through co-injection of a trivalent affibody for in vivo blocking of …
M Rosestedt, KG Andersson, SS Rinne, CD Leitao, B Mitran, A Vorobyeva, ...
Scientific Reports 9 (1), 6779, 2019
82019
HER3 PET Imaging: 68Ga-Labeled Affibody Molecules Provide Superior HER3 Contrast to 89Zr-Labeled Antibody and Antibody-Fragment-Based Tracers
SS Rinne, CD Leitao, A Abouzayed, A Vorobyeva, V Tolmachev, S Ståhl, ...
Cancers 13 (19), 4791, 2021
72021
Targeting tumor cells overexpressing the human epidermal growth factor receptor 3 with potent drug conjugates based on affibody molecules
SS Rinne, W Yin, AM Borras, A Abouzayed, CD Leitao, A Vorobyeva, ...
Biomedicines 10 (6), 1293, 2022
42022
Cloning of affibody libraries for display methods
S Ståhl, LC Hjelm, CD Leitao, J Löfblom, H Lindberg
Cold Spring Harbor Protocols, 2023
32023
Generation of an anti-idiotypic affibody-based masking domain for conditional activation of EGFR-targeting
AM Borras, CD Leitao, S Ståhl, J Löfblom
New Biotechnology 73, 9-18, 2023
32023
Selection of affibody molecules using phage display
LC Hjelm, CD Leitao, S Ståhl, J Löfblom, H Lindberg
Cold Spring Harbor Protocols, 2023
22023
Selection of affibody molecules using staphylococcal display
J Löfblom, LC Hjelm, CD Leitao, S Ståhl, H Lindberg
Cold Spring Harbor Protocols, 2023
22023
Display of a naïve affibody library on staphylococci for selection of binders by means of flow cytometry sorting
CD Leitao, AM Borras, A Jonsson, M Malm, N Kronqvist, F Fleetwood, ...
Biochemical and Biophysical Research Communications 655, 75-81, 2023
12023
Conditionally activated affibody-based prodrug targeting EGFR demonstrates improved tumour selectivity
CD Leitao, AM Borras, T Xu, M Oroujeni, Y Liu, C Westerberg, J Clinton, ...
Journal of Controlled Release 357, 185-195, 2023
12023
Engineering of Affibody Molecules
S Ståhl, H Lindberg, LC Hjelm, J Löfblom, CD Leitao
Cold Spring Harbor Protocols, 2023
2023
Selection of Affibody Molecules Using Escherichia coli Display
CD Leitao, LC Hjelm, S Ståhl, J Löfblom, H Lindberg
Cold Spring Harbor Protocols, 2023
2023
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Artiklar 1–20