Vincent Setola
Vincent Setola
West Virginia University School of Medicine
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Predicting new molecular targets for known drugs
MJ Keiser, V Setola, JJ Irwin, C Laggner, AI Abbas, SJ Hufeisen, ...
Nature 462 (7270), 175-181, 2009
Automated design of ligands to polypharmacological profiles
J Besnard, GF Ruda, V Setola, K Abecassis, RM Rodriguiz, XP Huang, ...
Nature 492 (7428), 215-220, 2012
Discovery of a novel member of the histamine receptor family
T Nguyen, DA Shapiro, SR George, V Setola, DK Lee, R Cheng, L Rauser, ...
Molecular pharmacology 59 (3), 427-433, 2001
Discovery of β-arrestin–biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy
JA Allen, JM Yost, V Setola, X Chen, MF Sassano, M Chen, S Peterson, ...
Proceedings of the National Academy of Sciences 108 (45), 18488-18493, 2011
3, 4-methylenedioxymethamphetamine (MDMA,“Ecstasy”) induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro
V Setola, SJ Hufeisen, KJ Grande-Allen, I Vesely, RA Glennon, B Blough, ...
Molecular pharmacology 63 (6), 1223-1229, 2003
Ligand discovery from a dopamine D3 receptor homology model and crystal structure
J Carlsson, RG Coleman, V Setola, JJ Irwin, H Fan, A Schlessinger, A Sali, ...
Nature chemical biology 7 (11), 769-778, 2011
Serotonin receptors and heart valve disease—it was meant 2B
JD Hutcheson, V Setola, BL Roth, WD Merryman
Pharmacology & therapeutics 132 (2), 146-157, 2011
Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil
D Zolkowska, R Jain, RB Rothman, JS Partilla, BL Roth, V Setola, ...
Journal of Pharmacology and Experimental Therapeutics 329 (2), 738-746, 2009
Identifying mechanism-of-action targets for drugs and probes
E Gregori-Puigjané, V Setola, J Hert, BA Crews, JJ Irwin, E Lounkine, ...
Proceedings of the National Academy of Sciences 109 (28), 11178-11183, 2012
Neurochemical profiles of some novel psychoactive substances
L Iversen, S Gibbons, R Treble, V Setola, XP Huang, BL Roth
European journal of pharmacology 700 (1-3), 147-151, 2013
The ketamine analogue methoxetamine and 3-and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor
BL Roth, S Gibbons, W Arunotayanun, XP Huang, V Setola, R Treble, ...
PloS one 8 (3), e59334, 2013
Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy
F Jaffré, P Bonnin, J Callebert, H Debbabi, V Setola, S Doly, L Monassier, ...
Circulation research 104 (1), 113-123, 2009
Serotonin 5-HT2B receptors are required for 3, 4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro
S Doly, E Valjent, V Setola, J Callebert, D Hervé, JM Launay, L Maroteaux
Journal of Neuroscience 28 (11), 2933-2940, 2008
Chemical informatics and target identification in a zebrafish phenotypic screen
C Laggner, D Kokel, V Setola, A Tolia, H Lin, JJ Irwin, MJ Keiser, ...
Nature chemical biology 8 (2), 144-146, 2012
Structure–Functional Selectivity Relationship Studies of β-Arrestin-Biased Dopamine D2 Receptor Agonists
X Chen, MF Sassano, L Zheng, V Setola, M Chen, X Bai, SV Frye, ...
Journal of medicinal chemistry 55 (16), 7141-7153, 2012
Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine2B receptor agonists: implications for drug safety assessment
XP Huang, V Setola, PN Yadav, JA Allen, SC Rogan, BJ Hanson, ...
Molecular pharmacology 76 (4), 710-722, 2009
Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice
JPR Jacobsen, WB Siesser, BD Sachs, S Peterson, MJ Cools, V Setola, ...
Molecular psychiatry 17 (7), 694-704, 2012
5-HT2B antagonism arrests non-canonical TGF-β1-induced valvular myofibroblast differentiation
JD Hutcheson, LM Ryzhova, V Setola, WD Merryman
Journal of molecular and cellular cardiology 53 (5), 707-714, 2012
Photochemical activation of TRPA1 channels in neurons and animals
D Kokel, CYJ Cheung, R Mills, J Coutinho-Budd, L Huang, V Setola, ...
Nature chemical biology 9 (4), 257-263, 2013
Design, synthesis, and validation of a β-turn mimetic library targeting protein–protein and peptide–receptor interactions
LR Whitby, Y Ando, V Setola, PK Vogt, BL Roth, DL Boger
Journal of the American Chemical Society 133 (26), 10184-10194, 2011
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