| Discovering novel ligands for macromolecules using X-ray crystallographic screening VL Nienaber, PL Richardson, V Klighofer, JJ Bouska, VL Giranda, J Greer Nature biotechnology 18 (10), 1105-1108, 2000 | 417 | 2000 |
| A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase S Atwell, JM Adams, J Badger, MD Buchanan, IK Feil, KJ Froning, X Gao, ... Journal of Biological Chemistry 279 (53), 55827-55832, 2004 | 230 | 2004 |
| Novel inhibitors of Erm methyltransferases from NMR and parallel synthesis PJ Hajduk, J Dinges, JM Schkeryantz, D Janowick, M Kaminski, M Tufano, ... Journal of medicinal chemistry 42 (19), 3852-3859, 1999 | 165 | 1999 |
| Crystal structure of ErmC ‘, an rRNA methyltransferase which mediates antibiotic resistance in bacteria DE Bussiere, SW Muchmore, CG Dealwis, G Schluckebier, VL Nienaber, ... Biochemistry 37 (20), 7103-7112, 1998 | 152 | 1998 |
| Identification of novel inhibitors of urokinase via NMR-based screening PJ Hajduk, S Boyd, D Nettesheim, V Nienaber, J Severin, R Smith, ... Journal of medicinal chemistry 43 (21), 3862-3866, 2000 | 122 | 2000 |
| Automated crystal mounting and data collection for protein crystallography SW Muchmore, J Olson, R Jones, J Pan, M Blum, J Greer, SM Merrick, ... Structure 8 (12), R243-R246, 2000 | 120 | 2000 |
| Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization WJ Sanders, VL Nienaber, CG Lerner, JO McCall, SM Merrick, ... Journal of medicinal chemistry 47 (7), 1709-1718, 2004 | 110 | 2004 |
| Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury M Pyzik, T Rath, TT Kuo, S Win, K Baker, JJ Hubbard, R Grenha, ... Proceedings of the National Academy of Sciences 114 (14), E2862-E2871, 2017 | 106 | 2017 |
| Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N … MD Wendt, TW Rockway, A Geyer, W McClellan, M Weitzberg, X Zhao, ... Journal of medicinal chemistry 47 (2), 303-324, 2004 | 89 | 2004 |
| A glutamic acid specific serine protease utilizes a novel histidine triad in substrate binding VL Nienaber, K Breddam, JJ Birktoft Biochemistry 32 (43), 11469-11475, 1993 | 87 | 1993 |
| Structure-directed discovery of potent non-peptidic inhibitors of human urokinase that access a novel binding subsite VL Nienaber, D Davidson, R Edalji, VL Giranda, V Klinghofer, J Henkin, ... Structure 8 (5), 553-563, 2000 | 79 | 2000 |
| Inhibitors of the protease domain of urokinase-type plasminogen activator TW Rockway, V Nienaber, VL Giranda Current pharmaceutical design 8 (28), 2541-2558, 2002 | 78 | 2002 |
| Re-engineering of human urokinase provides a system for structure-based drug design at high resolution and reveals a novel structural subsite V Nienaber, J Wang, D Davidson, J Henkin Journal of Biological Chemistry 275 (10), 7239-7248, 2000 | 78 | 2000 |
| Automated sample handling for X-ray crystallography JA Olson, RB Jones, VL Nienaber, SW Muchmore, JY Pan, J Greer US Patent 6,404,849, 2002 | 56 | 2002 |
| Ligand screening and design by x-ray crystallography VL Nienaber, J Greer, C Abad-Zapatero, DW Norbeck US Patent 6,297,021, 2001 | 55 | 2001 |
| X-ray crystal structures of monomeric and dimeric peptide inhibitors in complex with the human neonatal Fc receptor, FcRn AR Mezo, V Sridhar, J Badger, P Sakorafas, V Nienaber Journal of biological chemistry 285 (36), 27694-27701, 2010 | 47 | 2010 |
| Fragment‐based Lead Discovery and Optimization Using X‐Ray Crystallography, Computational Chemistry, and High‐throughput Organic Synthesis J Blaney, V Nienaber, SK Burley Fragment‐based Approaches in Drug Discovery, 215-248, 2006 | 45 | 2006 |
| Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties M Bruncko, WJ McClellan, MD Wendt, DR Sauer, A Geyer, CR Dalton, ... Bioorganic & medicinal chemistry letters 15 (1), 93-98, 2005 | 37 | 2005 |
| Species specificity of amidine-based urokinase inhibitors V Klinghofer, K Stewart, T McGonigal, R Smith, A Sarthy, V Nienaber, ... Biochemistry 40 (31), 9125-9131, 2001 | 37 | 2001 |
| Conformational similarities between one-chain and two-chain tissue plasminogen activator (t-PA): implications to the activation mechanism on one-chain t-PA VL Nienaber, SL Young, JJ Birktoft, DL Higgins, LJ Berliner Biochemistry 31 (15), 3852-3861, 1992 | 35 | 1992 |
