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Lars Linden
Lars Linden
Bayer
Verified email at genion.de
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Cited by
Cited by
Year
Anetumab ravtansine: a novel mesothelin-targeting antibody–drug conjugate cures tumors with heterogeneous target expression favored by bystander effect
S Golfier, C Kopitz, A Kahnert, I Heisler, CA Schatz, B Stelte-Ludwig, ...
Molecular cancer therapeutics 13 (6), 1537-1548, 2014
2232014
The Crystal Structures of Zea mays and Arabidopsis 4-Hydroxyphenylpyruvate Dioxygenase
IM Fritze, L Linden, J Freigang, G Auerbach, R Huber, S Steinbacher
Plant Physiology 134 (4), 1388-1400, 2004
1442004
With or without sugar?(A) glycosylation of therapeutic antibodies
D Hristodorov, R Fischer, L Linden
Molecular biotechnology 54, 1056-1068, 2013
822013
Generation and comparative characterization of glycosylated and aglycosylated human IgG1 antibodies
D Hristodorov, R Fischer, H Joerissen, B Müller-Tiemann, H Apeler, ...
Molecular biotechnology 53, 326-335, 2013
782013
Synergistic effect of a mesothelin-targeted 227Th conjugate in combination with DNA damage response inhibitors in ovarian cancer xenograft models
K Wickstroem, UB Hagemann, V Cruciani, AM Wengner, A Kristian, ...
Journal of Nuclear Medicine 60 (9), 1293-1300, 2019
462019
Preclinical antitumor efficacy of BAY 1129980—a novel auristatin-based anti-C4. 4A (LYPD3) antibody–drug conjugate for the treatment of non–small cell lung cancer
J Willuda, L Linden, HG Lerchen, C Kopitz, B Stelte-Ludwig, C Pena, ...
Molecular cancer therapeutics 16 (5), 893-904, 2017
442017
Salt-induced aggregation of a monoclonal human immunoglobulin G1
J Rubin, L Linden, WM Coco, AS Bommarius, SH Behrens
Journal of Pharmaceutical Sciences 102 (2), 377-386, 2013
362013
New binder-drug conjugates (adcs) and use thereof
HG Lerchen, L Linden, S El Sheikh, J Willuda, CC Kopitz, J Schuhmacher, ...
US Patent App. 15/052,655, 2016
34*2016
Calcium modulates rapid protein phosphorylation/dephosphorylation in isolated eyespot apparatuses of the green alga Spermatozopsis similis
L Linden, G Kreimer
Planta 197 (2), 343-351, 1995
341995
Synergistic effect of a HER2 targeted thorium-227 conjugate in combination with olaparib in a BRCA2 deficient xenograft model
K Wickstroem, J Karlsson, C Ellingsen, V Cruciani, A Kristian, ...
Pharmaceuticals 12 (4), 155, 2019
322019
Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia
XY Zhao, A Wilmen, D Wang, X Wang, M Bauzon, JY Kim, L Linden, L Li, ...
Nature Communications 11 (1), 2992, 2020
252020
Relaxin fusion polypeptides and uses thereof
A Wilmen, U Haupts, C Freiberg, M Trautwein, L Linden, K Leineweber, ...
US Patent 9,382,305, 2016
242016
REFOLDED MEMBRANE PROTEIN IN MONODISPERSE FORM
L LINDEN, S PRYTULLA, T OSTERMANN, M BAEHNER, T ROOS, ...
WO Patent 2,005,058,942, 2005
242005
Biophysical and sequence-based methods for identifying monovalent and bivalent antibodies with high colloidal stability
ME Alam, SB Geng, C Bender, SD Ludwig, L Linden, R Hoet, PM Tessier
Molecular Pharmaceutics 15 (1), 150-163, 2018
232018
G proteins and Ca2+-modulated protein kinases of a plasma membrane-enriched fraction and isolated eyespot apparatuses of Spermatozopsis similis (Chlorophyceae)
U Schlicher, L Linden, M Calenberg, G Kreimer
European Journal of Phycology 30 (4), 319-330, 1995
231995
Preclinical combination studies of an FGFR2 targeted thorium-227 conjugate and the ATR inhibitor BAY 1895344
K Wickstroem, UB Hagemann, A Kristian, C Ellingsen, A Sommer, ...
International Journal of Radiation Oncology* Biology* Physics 105 (2), 410-422, 2019
212019
Gauging colloidal and thermal stability in human IgG1–sugar solutions through diffusivity measurements
J Rubin, A Sharma, L Linden, AS Bommarius, SH Behrens
The Journal of Physical Chemistry B 118 (11), 2803-2809, 2014
212014
NOVEL BINDER-DRUG CONJUGATES (ADCS) AND THEIR USE
HG LERCHEN, L LINDEN, S EL SHEIKH, J WILLUDA, C KOPITZ, ...
WO Patent 2,012,143,497, 2012
18*2012
Neutralizing prolactin receptor antibody Mat3 and its therapeutic use
C Freiberg, C Otto, L Linden, A Harrenga, M Trautwein, S Greven, ...
US Patent 9,353,186, 2016
152016
Evaluation of human pancreatic RNase as effector molecule in a therapeutic antibody platform
T Schirrmann, A Frenzel, L Linden, B Stelte-Ludwig, J Willuda, ...
MAbs 6 (2), 367-380, 2014
122014
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