| Fast, scalable prediction of deleterious noncoding variants from functional and population genomic data YF Huang, B Gulko, A Siepel Nature Genetics 49 (4), 618-624, 2017 | 278 | 2017 |
| Is a super-enhancer greater than the sum of its parts? N Dukler, B Gulko, YF Huang, A Siepel Nature Genetics 49 (1), 2-3, 2017 | 71 | 2017 |
| Non-B DNA: a major contributor to small-and large-scale variation in nucleotide substitution frequencies across the genome WM Guiblet, MA Cremona, RS Harris, D Chen, KA Eckert, F Chiaromonte, ... Nucleic acids research 49 (3), 1497-1516, 2021 | 46 | 2021 |
| Robust high-performance nanoliter-volume single-cell multiple displacement amplification on planar substrates K Leung, A Klaus, BK Lin, E Laks, J Biele, D Lai, A Bashashati, YF Huang, ... Proceedings of the National Academy of Sciences 113 (30), 8484-8489, 2016 | 44 | 2016 |
| Scikit-ribo enables accurate estimation and robust modeling of translation dynamics at codon resolution H Fang, YF Huang, A Radhakrishnan, A Siepel, GJ Lyon, MC Schatz Cell systems 6 (2), 180-191. e4, 2018 | 37 | 2018 |
| PhastWeb: a web interface for evolutionary conservation scoring of multiple sequence alignments using phastCons and phyloP R Ramani, K Krumholz, YF Huang, A Siepel Bioinformatics 35 (13), 2320-2322, 2019 | 36 | 2019 |
| Characterizing RNA stability genome-wide through combined analysis of PRO-seq and RNA-seq data A Blumberg, Y Zhao, YF Huang, N Dukler, EJ Rice, AG Chivu, K Krumholz, ... BMC biology 19 (1), 1-17, 2021 | 35 | 2021 |
| Nascent RNA sequencing reveals a dynamic global transcriptional response at genes and enhancers to the natural medicinal compound celastrol N Dukler, GT Booth, YF Huang, N Tippens, CT Waters, CG Danko, JT Lis, ... Genome research 27 (11), 1816-1829, 2017 | 30 | 2017 |
| Estimation of allele-specific fitness effects across human protein-coding sequences and implications for disease YF Huang, A Siepel Genome Research 29 (8), 1310-1321, 2019 | 23 | 2019 |
| Phylogenetic Gaussian process model for the inference of functionally important regions in protein tertiary structures YF Huang, GB Golding PLoS computational biology 10 (1), e1003429, 2014 | 21 | 2014 |
| FuncPatch: a web server for the fast Bayesian inference of conserved functional patches in protein 3D structures YF Huang, GB Golding Bioinformatics 31 (4), 523-531, 2015 | 19 | 2015 |
| Evidence against the energetic cost hypothesis for the short introns in highly expressed genes YF Huang, DK Niu BMC Evolutionary Biology 8, 1-9, 2008 | 19 | 2008 |
| Selection and thermostability suggest G-quadruplexes are novel functional elements of the human genome WM Guiblet, M DeGiorgio, X Cheng, F Chiaromonte, KA Eckert, YF Huang, ... Genome research 31 (7), 1136-1149, 2021 | 13 | 2021 |
| Extreme purifying selection against point mutations in the human genome N Dukler, MR Mughal, R Ramani, YF Huang, A Siepel Nature communications 13 (1), 4312, 2022 | 12 | 2022 |
| Inferring sequence regions under functional divergence in duplicate genes YF Huang, GB Golding Bioinformatics 28 (2), 176-183, 2012 | 12 | 2012 |
| Dissecting genomic determinants of positive selection with an evolution-guided regression model YF Huang Molecular biology and evolution 39 (1), msab291, 2022 | 10 | 2022 |
| Unified inference of missense variant effects and gene constraints in the human genome YF Huang PLoS genetics 16 (7), e1008922, 2020 | 10 | 2020 |
| Phylogenetic modeling of regulatory element turnover based on epigenomic data N Dukler, YF Huang, A Siepel Molecular biology and evolution 37 (7), 2137-2152, 2020 | 8 | 2020 |
| Distinct sequencing success at non-B-DNA motifs MH Weissensteiner, MA Cremona, W Guiblet, N Stoler, RS Harris, ... bioRxiv, 2022.06. 13.495922, 2022 | 1 | 2022 |
| Transcription factor binding sites are frequently under accelerated evolution in primates X Zhang, B Fang, YF Huang Nature Communications 14 (1), 783, 2023 | | 2023 |
Adam SiepelSimons Center for Quantitative Biology, Cold Spring Harbor LaboratoryVerified email at cshl.edu
