| Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition SG Sarafianos, B Marchand, K Das, DM Himmel, MA Parniak, SH Hughes, ... Journal of molecular biology 385 (3), 693-713, 2009 | 707 | 2009 |
| Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that … K Das, AD Clark, PJ Lewi, J Heeres, MR De Jonge, LMH Koymans, ... Journal of medicinal chemistry 47 (10), 2550-2560, 2004 | 642 | 2004 |
| Crystal structure of HIV‐1 reverse transcriptase in complex with a polypurine tract RNA: DNA SG Sarafianos, K Das, C Tantillo, AD ClarkJr, J Ding, JM Whitcomb, ... The EMBO journal, 2001 | 533 | 2001 |
| Structures of influenza A proteins and insights into antiviral drug targets K Das, JM Aramini, LC Ma, RM Krug, E Arnold Nature structural & molecular biology 17 (5), 530-538, 2010 | 474 | 2010 |
| Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors J Ding, K Das, H Moereels, L Koymans, K Andries, PAJ Janssen, ... Nature structural biology 2 (5), 407-415, 1995 | 453 | 1995 |
| In Search of a Novel Anti-HIV Drug: Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl … PAJ Janssen, PJ Lewi, E Arnold, F Daeyaert, M De Jonge, J Heeres, ... Journal of medicinal chemistry 48 (6), 1901-1909, 2005 | 426 | 2005 |
| Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2 … J Ding, K Das, Y Hsiou, SG Sarafianos, AD Clark Jr, A Jacobo-Molina, ... Journal of molecular biology 284 (4), 1095-1111, 1998 | 421 | 1998 |
| High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations K Das, JD Bauman, AD Clark Jr, YV Frenkel, PJ Lewi, AJ Shatkin, ... Proceedings of the National Academy of Sciences 105 (5), 1466-1471, 2008 | 401 | 2008 |
| Structure of unliganded HIV-1 reverse transcriptase at 2.7 Å resolution: implications of conformational changes for polymerization and inhibition mechanisms Y Hsiou, J Ding, K Das, AD Clark Jr, SH Hughes, E Arnold Structure 4 (7), 853-860, 1996 | 397 | 1996 |
| Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with β-branched amino acids SG Sarafianos, K Das, AD Clark Jr, J Ding, PL Boyer, SH Hughes, ... Proceedings of the national academy of sciences 96 (18), 10027-10032, 1999 | 393 | 1999 |
| The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro WE Delaney IV, H Yang, CE Westland, K Das, E Arnold, CS Gibbs, ... Journal of virology 77 (21), 11833-11841, 2003 | 354 | 2003 |
| Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC) K Das, X Xiong, H Yang, CE Westland, CS Gibbs, SG Sarafianos, ... Journal of virology 75 (10), 4771-4779, 2001 | 348 | 2001 |
| Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant K Das, J Ding, Y Hsiou, AD Clark Jr, H Moereels, L Koymans, K Andries, ... Journal of molecular biology 264 (5), 1085-1100, 1996 | 304 | 1996 |
| Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse … K Das, PJ Lewi, SH Hughes, E Arnold Progress in biophysics and molecular biology 88 (2), 209-231, 2005 | 297 | 2005 |
| Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues DW Ludovici, BL De Corte, MJ Kukla, H Ye, CY Ho, MA Lichtenstein, ... Bioorganic & medicinal chemistry letters 11 (17), 2235-2239, 2001 | 285 | 2001 |
| Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor α-APA R 95845 at 2.8 Å resolution J Ding, K Das, C Tantillo, W Zhang, AD Clark Jr, S Jessen, X Lu, Y Hsiou, ... Structure 3 (4), 365-379, 1995 | 283 | 1995 |
| The RNA polymerase “switch region” is a target for inhibitors J Mukhopadhyay, K Das, S Ismail, D Koppstein, M Jang, B Hudson, ... Cell 135 (2), 295-307, 2008 | 275 | 2008 |
| Structures of HIV‐1 reverse transcriptase with pre‐and post‐translocation AZTMP‐terminated DNA SG Sarafianos, AD ClarkJr, K Das, S Tuske, JJ Birktoft, P Ilankumaran, ... The EMBO journal, 2002 | 260 | 2002 |
| Structural basis for suppression of a host antiviral response by influenza A virus K Das, LC Ma, R Xiao, B Radvansky, J Aramini, L Zhao, J Marklund, ... Proceedings of the National Academy of Sciences 105 (35), 13093-13098, 2008 | 250 | 2008 |
| The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance Y Hsiou, J Ding, K Das, AD Clark Jr, PL Boyer, P Lewi, PAJ Janssen, ... Journal of molecular biology 309 (2), 437-445, 2001 | 246 | 2001 |
Eddy ArnoldBoard of Governors and Distinguished Professor of Chemistry and Chemical Biology, Rutgers UniversityVerified email at cabm.rutgers.edu
