|mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs|
RJO Dowling, I Topisirovic, T Alain, M Bidinosti, BD Fonseca, ...
Science 328 (5982), 1172-1176, 2010
|Dissecting the role of mTOR: lessons from mTOR inhibitors|
RJO Dowling, I Topisirovic, BD Fonseca, N Sonenberg
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (3), 433-439, 2010
|Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling|
AD Balgi, BD Fonseca, E Donohue, TCF Tsang, P Lajoie, CG Proud, ...
PloS one 4 (9), e7124, 2009
|PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex|
BD Fonseca, EM Smith, VHY Lee, C MacKintosh, CG Proud
Journal of Biological Chemistry 282 (34), 24514-24524, 2007
|Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling|
X Wang, BD Fonseca, H Tang, R Liu, A Elia, MJ Clemens, UA Bommer, ...
Journal of Biological Chemistry 283 (45), 30482-30492, 2008
|Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1|
J Averous, BD Fonseca, CG Proud
Oncogene 27 (8), 1106-1113, 2008
|eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies|
T Alain, M Morita, BD Fonseca, A Yanagiya, N Siddiqui, M Bhat, D Zammit, ...
Cancer research 72 (24), 6468-6476, 2012
|La-related protein 1 (LARP1) represses terminal oligopyrimidine (TOP) mRNA translation downstream of mTOR complex 1 (mTORC1)|
BD Fonseca, C Zakaria, JJ Jia, TE Graber, Y Svitkin, S Tahmasebi, ...
Journal of Biological Chemistry 290 (26), 15996-16020, 2015
|A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development|
M Morita, LW Ler, MR Fabian, N Siddiqui, M Mullin, VC Henderson, ...
Molecular and cellular biology 32 (17), 3585-3593, 2012
|Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling|
BD Fonseca, GH Diering, MA Bidinosti, K Dalal, T Alain, AD Balgi, ...
Journal of Biological Chemistry 287 (21), 17530-17545, 2012
|La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs|
RM Lahr, BD Fonseca, GE Ciotti, HA Al-Ashtal, JJ Jia, MR Niklaus, ...
Elife 6, e24146, 2017
|Regulation of mTORC1 signaling by pH|
AD Balgi, GH Diering, E Donohue, KKY Lam, BD Fonseca, C Zimmerman, ...
PloS one 6 (6), e21549, 2011
|Calpain activity is generally elevated during transformation but has oncogene-specific biological functions|
NO Carragher, BD Fonseca, MC Frame
Neoplasia 6 (1), 53-73, 2004
|The ever-evolving role of mTOR in translation|
BD Fonseca, EM Smith, N Yelle, T Alain, M Bushell, A Pause
Seminars in cell & developmental biology 36, 102-112, 2014
|S6K-STING interaction regulates cytosolic DNA–mediated activation of the transcription factor IRF3|
F Wang, T Alain, KJ Szretter, K Stephenson, JG Pol, MJ Atherton, ...
Nature immunology 17 (5), 514-522, 2016
|Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated …|
BD Fonseca, T Alain, LK Finestone, BPH Huang, M Rolfe, T Jiang, Z Yao, ...
Journal of Biological Chemistry 286 (31), 27111-27122, 2011
|Analysis of the regulatory motifs in eukaryotic initiation factor 4E‐binding protein 1|
VHY Lee, T Healy, BD Fonseca, A Hayashi, CG Proud
The FEBS journal 275 (9), 2185-2199, 2008
|The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK|
BD Fonseca, VHY Lee, CG Proud
Biochemical Journal 411 (1), 141-149, 2008
|LARP1 on TOP of ribosome production|
BD Fonseca, RM Lahr, CK Damgaard, T Alain, AJ Berman
Wiley Interdisciplinary Reviews: RNA 9 (5), e1480, 2018
|Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3|
Y Tsukumo, T Alain, BD Fonseca, R Nadon, N Sonenberg
Nature communications 7 (1), 1-13, 2016