| In silico design of novel probes for the atypical opioid receptor MRGPRX2 K Lansu, J Karpiak, J Liu, XP Huang, JD McCorvy, WK Kroeze, T Che, ... Nature chemical biology 13 (5), 529-536, 2017 | 220 | 2017 |
| Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65 XP Huang, J Karpiak, WK Kroeze, H Zhu, X Chen, SS Moy, KA Saddoris, ... Nature 527 (7579), 477-483, 2015 | 213 | 2015 |
| Structure-based ligand discovery for the protein–protein interface of chemokine receptor CXCR4 MM Mysinger, DR Weiss, JJ Ziarek, S Gravel, AK Doak, J Karpiak, ... Proceedings of the National Academy of Sciences 109 (14), 5517-5522, 2012 | 158 | 2012 |
| Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs JD McCorvy, KV Butler, B Kelly, K Rechsteiner, J Karpiak, RM Betz, ... Nature chemical biology 14 (2), 126-134, 2018 | 126 | 2018 |
| Structural basis of G protein–coupled receptor–G protein interactions J Hu, Y Wang, X Zhang, JR Lloyd, JH Li, J Karpiak, S Costanzi, J Wess Nature chemical biology 6 (7), 541-548, 2010 | 97 | 2010 |
| Design, synthesis, crystal structures, and antimicrobial activity of sulfonamide boronic acids as β-lactamase inhibitors O Eidam, C Romagnoli, E Caselli, K Babaoglu, DT Pohlhaus, J Karpiak, ... Journal of medicinal chemistry 53 (21), 7852-7863, 2010 | 88 | 2010 |
| Actin is required for IFT regulation in Chlamydomonas reinhardtii P Avasthi, M Onishi, J Karpiak, R Yamamoto, L Mackinder, MC Jonikas, ... Current Biology 24 (17), 2025-2032, 2014 | 66 | 2014 |
| Structure, function and pharmacology of human itch GPCRs C Cao, HJ Kang, I Singh, H Chen, C Zhang, W Ye, BW Hayes, J Liu, ... Nature 600 (7887), 170-175, 2021 | 64 | 2021 |
| In silico analysis of the binding of agonists and blockers to the β 2-adrenergic receptor S Vilar, J Karpiak, B Berk, S Costanzi Journal of Molecular Graphics and Modelling 29 (6), 809-817, 2011 | 59 | 2011 |
| Ligand and structure‐based models for the prediction of ligand‐receptor affinities and virtual screenings: Development and application to the β2‐adrenergic receptor S Vilar, J Karpiak, S Costanzi Journal of computational chemistry 31 (4), 707-720, 2010 | 52 | 2010 |
| Selectivity Challenges in Docking Screens for GPCR Targets and Antitargets DR Weiss, J Karpiak, XP Huang, MF Sassano, J Lyu, BL Roth, ... Journal of medicinal chemistry 61 (15), 6830-6845, 2018 | 32 | 2018 |
| Small-molecule allosteric modulators of the protein kinase PDK1 from structure-based docking TJ Rettenmaier, H Fan, J Karpiak, A Doak, A Sali, BK Shoichet, JA Wells Journal of medicinal chemistry 58 (20), 8285-8291, 2015 | 25 | 2015 |
| Quantification of the transferability of a designed protein specificity switch reveals extensive epistasis in molecular recognition C Melero, N Ollikainen, I Harwood, J Karpiak, T Kortemme Proceedings of the National Academy of Sciences 111 (43), 15426-15431, 2014 | 24 | 2014 |
| Structural basis of the selectivity of the β 2-adrenergic receptor for fluorinated catecholamines C Pooput, E Rosemond, J Karpiak, F Deflorian, S Vilar, S Costanzi, ... Bioorganic & medicinal chemistry 17 (23), 7987-7992, 2009 | 17 | 2009 |
| Designing for developability: Machine learning in data-driven drug discovery J Karpiak ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 258, 2019 | | 2019 |
| Challenges and opportunities in structure-based discovery for GPCR targets and antitargets J Karpiak, D Weiss, XP Huang, M Sassano, B Shoichet, B Roth ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 255, 2018 | | 2018 |
| Shooting in the dark: Strategies for discovering magic bullets and magic shotguns for orphan GPCRs JD Karpiak UCSF, 2015 | | 2015 |
| Teach-Discover-Treat 2014, part 3: Molecular docking with DOCK 3.7 J Karpiak, RG Coleman ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 248, 2014 | | 2014 |
| G-protein coupled receptors in virtual screening: Functional fidelity and selectivity DR Weiss, SK Ahn, MF Sassano, AC Kruse, J Karpiak, BL Roth, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 245, 2013 | | 2013 |
| Crosslinking Analysis of the M3 Muscarinic Acetylcholine Receptor/G alpha q Interface in Both the Inactive and Active States J Hu, Y Wang, X Zhang, JR Lloyd, J Li, J Karpiak, S Costanzi, J Wess The FASEB Journal 24, lb479-lb479, 2010 | | 2010 |
