| A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice C Escribano-Díaz, A Orthwein, A Fradet-Turcotte, M Xing, JTF Young, ... Molecular cell 49 (5), 872-883, 2013 | 1006 | 2013 |
| 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark A Fradet-Turcotte, MD Canny, C Escribano-Díaz, A Orthwein, CCY Leung, ... Nature 499 (7456), 50-54, 2013 | 713 | 2013 |
| A mechanism for the suppression of homologous recombination in G1 cells A Orthwein, SM Noordermeer, MD Wilson, S Landry, RI Enchev, ... Nature 528 (7582), 422-426, 2015 | 528 | 2015 |
| A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer P Polak, J Kim, LZ Braunstein, R Karlic, NJ Haradhavala, G Tiao, ... Nature genetics 49 (10), 1476-1486, 2017 | 488 | 2017 |
| Mitosis inhibits DNA double-strand break repair to guard against telomere fusions A Orthwein, A Fradet-Turcotte, SM Noordermeer, MD Canny, CM Brun, ... Science 344 (6180), 189-193, 2014 | 356 | 2014 |
| MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection V Boersma, N Moatti, S Segura-Bayona, MH Peuscher, J Van der Torre, ... Nature 521 (7553), 537-540, 2015 | 292 | 2015 |
| Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency MD Canny, N Moatti, LCK Wan, A Fradet-Turcotte, D Krasner, ... Nature biotechnology 36 (1), 95-102, 2018 | 251 | 2018 |
| Active nuclear import and cytoplasmic retention of activation-induced deaminase AM Patenaude, A Orthwein, Y Hu, VA Campo, B Kavli, A Buschiazzo, ... Nature structural & molecular biology 16 (5), 517-527, 2009 | 179 | 2009 |
| HELB is a feedback inhibitor of DNA end resection J Tkáč, G Xu, H Adhikary, JTF Young, D Gallo, C Escribano-Díaz, ... Molecular cell 61 (3), 405-418, 2016 | 158 | 2016 |
| Productive human immunodeficiency virus type 1 assembly takes place at the plasma membrane A Finzi, A Orthwein, J Mercier, ÉA Cohen Journal of virology 81 (14), 7476-7490, 2007 | 145 | 2007 |
| SHLD 2/FAM 35A co‐operates with REV 7 to coordinate DNA double‐strand break repair pathway choice S Findlay, J Heath, VM Luo, A Malina, T Morin, Y Coulombe, B Djerir, Z Li, ... The EMBO journal 37 (18), e100158, 2018 | 129 | 2018 |
| Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90 A Orthwein, AM Patenaude, EB Affar, A Lamarre, JC Young, JM Di Noia Journal of Experimental Medicine 207 (12), 2751-2765, 2010 | 126 | 2010 |
| BRCA2 functions: from DNA repair to replication fork stabilization A Fradet-Turcotte, J Sitz, D Grapton, A Orthwein Endocr Relat Cancer 23 (10), T1-T17, 2016 | 97 | 2016 |
| CTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair K Hilmi, M Jangal, M Marques, T Zhao, A Saad, C Zhang, VM Luo, ... Science advances 3 (5), e1601898, 2017 | 77 | 2017 |
| Optimal functional levels of activation‐induced deaminase specifically require the Hsp40 DnaJa1 A Orthwein, A Zahn, SP Methot, D Godin, SG Conticello, K Terada, ... The EMBO journal 31 (3), 679-691, 2012 | 61 | 2012 |
| GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1 C Vadnais, R Chen, J Fraszczak, Z Yu, J Boulais, J Pinder, D Frank, ... Nature communications 9 (1), 1418, 2018 | 54 | 2018 |
| Activation induced deaminase: how much and where? A Orthwein, JM Di Noia Seminars in immunology 24 (4), 246-254, 2012 | 46 | 2012 |
| Functionally Null RAD51D Missense Mutation Associates Strongly with Ovarian Carcinoma B Rivera, M Di Iorio, J Frankum, J Nadaf, S Fahiminiya, SL Arcand, ... Cancer research 77 (16), 4517-4529, 2017 | 42 | 2017 |
| Mapping global and local coevolution across 600 species to identify novel homologous recombination repair genes D Sherill-Rofe, D Rahat, S Findlay, A Mellul, I Guberman, M Braun, I Bloch, ... Genome research 29 (3), 439-448, 2019 | 37 | 2019 |
| CRISPR/Cas9 gene editing: from basic mechanisms to improved strategies for enhanced genome engineering in vivo J Salsman, JY Masson, A Orthwein, G Dellaire Current Gene Therapy 17 (4), 263-274, 2017 | 20 | 2017 |
