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John M. Sanders
John M. Sanders
Structural Chemistry, Merck & Co., Inc.
Verified email at merck.com
Title
Cited by
Cited by
Year
Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole
G Benaim, JM Sanders, Y Garcia-Marchán, C Colina, R Lira, AR Caldera, ...
Journal of medicinal chemistry 49 (3), 892-899, 2006
2452006
Child day care risks of common infectious diseases revisited
N Lu, ME Samuels, L Shi, SL Baker, SH Glover, JM Sanders
Child: care, health and development 30 (4), 361-368, 2004
1882004
Quantitative structure− activity relationships for γδ T cell activation by bisphosphonates
JM Sanders, S Ghosh, JMW Chan, G Meints, H Wang, AM Raker, Y Song, ...
Journal of medicinal chemistry 47 (2), 375-384, 2004
1722004
Activity of bisphosphonates against Trypanosoma brucei rhodesiense
MB Martin, JM Sanders, H Kendrick, K de Luca-Fradley, JC Lewis, ...
Journal of medicinal chemistry 45 (14), 2904-2914, 2002
1472002
3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates
JM Sanders, AO Gómez, J Mao, GA Meints, EM Van Brussel, A Burzynska, ...
Journal of medicinal chemistry 46 (24), 5171-5183, 2003
1462003
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents
CM Szabo, Y Matsumura, S Fukura, MB Martin, JM Sanders, S Sengupta, ...
Journal of medicinal chemistry 45 (11), 2185-2196, 2002
1252002
Discovery of a 3-(4-pyrimidinyl) indazole (MLi-2), an orally available and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor that reduces brain kinase activity
JD Scott, DE DeMong, TJ Greshock, K Basu, X Dai, J Harris, A Hruza, ...
Journal of medicinal chemistry 60 (7), 2983-2992, 2017
1232017
Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma bruce in vitro RNA interference and in vivo inhibition studies
A Montalvetti, A Fernandez, JM Sanders, S Ghosh, E Van Brussel, ...
Journal of Biological Chemistry 278 (19), 17075-17083, 2003
1162003
Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase− bisphosphonate complexes
J Mao, S Mukherjee, Y Zhang, R Cao, JM Sanders, Y Song, Y Zhang, ...
Journal of the American Chemical Society 128 (45), 14485-14497, 2006
1072006
Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption
JM Sanders, Y Song, JMW Chan, Y Zhang, S Jennings, T Kosztowski, ...
Journal of medicinal chemistry 48 (8), 2957-2963, 2005
1072005
Crystallographic structures of two bisphosphonate: 1-deoxyxylulose-5-phosphate reductoisomerase complexes
S Yajima, K Hara, JM Sanders, F Yin, K Ohsawa, J Wiesner, H Jomaa, ...
Journal of the American Chemical Society 126 (35), 10824-10825, 2004
1042004
Maximizing diversity from a kinase screen: identification of novel and selective pan-Trk inhibitors for chronic pain
SJ Stachel, JM Sanders, DA Henze, MT Rudd, HP Su, Y Li, KK Nanda, ...
Journal of Medicinal Chemistry 57 (13), 5800-5816, 2014
772014
EphA4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer
HA Rajapakse, KP Moore, PG Nantermet, JM Sanders, ...
US Patent App. 12/473,773, 2010
722010
Measurements of multiple molecules using a CryoArray
RA Star, T Miyaji, SM Hewitt, LA Liotta
US Patent 6,951,761, 2005
592005
Epha4 rtk inhibitors for treatment of neurological and neurodegenerative disorders and cancer
PG Nantermet, HA Rajapakse, T Sagara, JM Sanders, H Zhu
US Patent App. 12/473,810, 2010
512010
Leucine-rich repeat kinase 2 (LRRK2) cellular biology: a review of recent advances in identifying physiological substrates and cellular functions
RE Drolet, JM Sanders, JT Kern
Journal of neurogenetics 25 (4), 140-151, 2011
492011
3-Aryl-5-phenoxymethyl-1, 3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts
EJ Brnardic, ME Fraley, RM Garbaccio, ME Layton, JM Sanders, ...
Bioorganic & medicinal chemistry letters 20 (10), 3129-3133, 2010
492010
Structural characterization of nonactive site, TrkA-selective kinase inhibitors
HP Su, K Rickert, C Burlein, K Narayan, M Bukhtiyarova, DM Hurzy, ...
Proceedings of the National Academy of Sciences 114 (3), E297-E306, 2017
472017
Structural characterization of non-active site, TrkA selective kinase inhibitors
H Su, K Rickert, K Narayan, C Burlein, M Bukhtiyarova, D Hurzy, C Stump, ...
PROTEIN SCIENCE 25, 161-162, 2016
472016
Synthesis and evaluation of heterocyclic catechol mimics as inhibitors of catechol-O-methyltransferase (COMT)
ST Harrison, MS Poslusney, JJ Mulhearn, Z Zhao, NR Kett, JW Schubert, ...
ACS medicinal chemistry letters 6 (3), 318-323, 2015
392015
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