Srinivasa P S Rao
Srinivasa P S Rao
Novartis Institute for Tropical Diseases
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The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis
SPS Rao, S Alonso, L Rand, T Dick, K Pethe
Proceedings of the National Academy of Sciences 105 (33), 11945-11950, 2008
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
K Pethe, P Bifani, J Jang, S Kang, S Park, S Ahn, J Jiricek, J Jung, ...
Nature medicine 19 (9), 1157-1160, 2013
Use of proteomics to identify novel virulence determinants that are required for Edwardsiella tarda pathogenesis
PS Srinivasa Rao, Y Yamada, YP Tan, KY Leung
Molecular microbiology 53 (2), 573-586, 2004
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
S Khare, AS Nagle, A Biggart, YH Lai, F Liang, LC Davis, SW Barnes, ...
Nature 537 (7619), 229-233, 2016
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
K Pethe, PC Sequeira, S Agarwalla, K Rhee, K Kuhen, WY Phong, V Patel, ...
Nature communications 1 (1), 1-8, 2010
Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability
M Gengenbacher, SPS Rao, K Pethe, T Dick
Microbiology 156 (1), 81-87, 2010
Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis
S Hasan, S Daugelat, PSS Rao, M Schreiber
PLoS Comput Biol 2 (6), e61, 2006
Opsonized virulent Edwardsiella tarda strains are able to adhere to and survive and replicate within fish phagocytes but fail to stimulate reactive oxygen intermediates
PSS Rao, TM Lim, KY Leung
Infection and immunity 69 (9), 5689-5697, 2001
A type III secretion system is required for Aeromonas hydrophila AH-1 pathogenesis
HB Yu, PSS Rao, HC Lee, S Vilches, S Merino, JM Tomas, KY Leung
Infection and immunity 72 (3), 1248-1256, 2004
The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease
EK Schmitt, M Riwanto, V Sambandamurthy, S Roggo, C Miault, ...
Angewandte Chemie 123 (26), 6011-6013, 2011
Functional genomics approach to the identification of virulence genes involved in Edwardsiella tarda pathogenesis
PSS Rao, TM Lim, KY Leung
Infection and immunity 71 (3), 1343-1351, 2003
Triacylglycerol utilization is required for regrowth of in vitro hypoxic nonreplicating Mycobacterium bovis bacillus Calmette-Guerin
KL Low, PSS Rao, G Shui, AK Bendt, K Pethe, T Dick, MR Wenk
Journal of bacteriology 191 (16), 5037-5043, 2009
The effectiveness of a commercial microbial product in poorly prepared tiger shrimp, Penaeus monodon (Fabricius), ponds
M Shariff, FM Yusoff, TN Devaraja, PSS Rao
Aquaculture Research 32 (3), 181-187, 2001
Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis
SPS Rao, SB Lakshminarayana, RR Kondreddi, M Herve, LR Camacho, ...
Science translational medicine 5 (214), 214ra168-214ra168, 2013
A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis
PA Mak, SPS Rao, M Ping Tan, X Lin, J Chyba, J Tay, SH Ng, BH Tan, ...
ACS chemical biology 7 (7), 1190-1197, 2012
A major catalase (KatB) that is required for resistance to H2O2 and phagocyte-mediated killing in Edwardsiella tarda
PSS Rao, Y Yamada, KY Leung
Microbiology 149 (9), 2635-2644, 2003
Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents
SB Lakshminarayana, TB Huat, PC Ho, UH Manjunatha, V Dartois, T Dick, ...
Journal of Antimicrobial Chemotherapy 70 (3), 857-867, 2015
Edwardsiella tarda mutants defective in siderophore production, motility, serum resistance and catalase activity
JA Mathew, YP Tan, PSS Rao, TM Lim, KY Leung
Microbiology 147 (2), 449-457, 2001
Design, synthesis and biological evaluation of indole-2-carboxamides, a promising class of anti-tuberculosis agents
PWS Ravinder Reddy Kondreddi, Jan Jiricek, Srinivasa P
Journal of Medicinal Chemistry, 2013
Direct inhibitors of InhA are active against Mycobacterium tuberculosis
UH Manjunatha, SPS Rao, RR Kondreddi, CG Noble, LR Camacho, ...
Science translational medicine 7 (269), 269ra3-269ra3, 2015
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