Bon-Kyoung Koo

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Hans CleversHubrecht Institute - UtrechtVerified email at hubrecht.eu
Young-yun KongProfessor of biological sciences, Seoul National UniversityVerified email at snu.ac.kr
Daniel E StangeTU DresdenVerified email at uniklinikum-dresden.de
Ki-Jun YoonKorea Advanced Institute of Science and Technology (KAIST)Verified email at kaist.ac.kr
Benjamin D SimonsUniversity of CambridgeVerified email at cam.ac.uk
Shabaz MohammedAssociate Professor of Proteomics, University of OxfordVerified email at bioch.ox.ac.uk
Albert J. R. HeckBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center and Utrecht UniversityVerified email at uu.nl
Edwin CuppenHoogleraar Humane GeneticaVerified email at umcutrecht.nl
Madelon MauriceProfessor of Molecular Cell Biology, Center for Molecular Medicine, UMC UtrechtVerified email at umcutrecht.nl
Hyun-Woo JeongMax-Planck Institute for Molecular BiomedicineVerified email at mpi-muenster.mpg.de
Mustata RCScientist, Stemcell Technologies UKVerified email at stemcell.com
Alexander van OudenaardenHubrecht InstituteVerified email at hubrecht.eu
Prof Nick BarkerA-STAR Institute of Molecular and Cellular Biology, SingaporeVerified email at imcb.a-star.edu.sg
Peter J. PetersProfessor of NanoBiology, Maastricht University, The NetherlandsVerified email at maastrichtuniversity.nl
Gerald SchwankUniversity ZurichVerified email at pharma.uzh.ch
Inha HeoHubrecht InstituteVerified email at hubrecht.eu
Shalev ItzkovitzProfessor, Weizmann Institute of ScienceVerified email at weizmann.ac.il
Javier MuñozBiobizkaia Health Research InstituteVerified email at bio-bizkaia.eus
turan demircanMugla Sitki Kocman University, Tıp FakültesiVerified email at mu.edu.tr
Onur BasakGroup leader at the Translational Neuroscience, BCRM, UMCU, Utrecht, theVerified email at umcutrecht.nl

Bon-Kyoung Koo

Center for Genome Engineering (CGE), Institute for Basic Science (IBS)

Verified email at ibs.re.kr

Intestine Stem cell Wnt Organoids CRISPR/Cas


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Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients G Schwank, BK Koo, V Sasselli, JF Dekkers, I Heo, T Demircan, N Sasaki, ... Cell stem cell 13 (6), 653-658, 2013	1595	2013
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling W De Lau, N Barker, TY Low, BK Koo, VSW Li, H Teunissen, P Kujala, ... Nature 476 (7360), 293-297, 2011	1394	2011
Human organoids: model systems for human biology and medicine J Kim, BK Koo, JA Knoblich Nature Reviews Molecular Cell Biology 21 (10), 571-584, 2020	1393	2020
Human primary liver cancer–derived organoid cultures for disease modeling and drug screening L Broutier, G Mastrogiovanni, MMA Verstegen, HE Francies, LM Gavarró, ... Nature medicine 23 (12), 1424-1435, 2017	1123	2017
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors BK Koo, M Spit, I Jordens, TY Low, DE Stange, M Van De Wetering, ... Nature 488 (7413), 665-669, 2012	971	2012
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+ 4’cell markers J Muñoz, DE Stange, AG Schepers, M Van De Wetering, BK Koo, ... The EMBO journal 31 (14), 3079-3091, 2012	818	2012
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation L Broutier, A Andersson-Rolf, CJ Hindley, SF Boj, H Clevers, BK Koo, ... Nature protocols 11 (9), 1724-1743, 2016	662	2016
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium DE Stange, BK Koo, M Huch, G Sibbel, O Basak, A Lyubimova, P Kujala, ... Cell 155 (2), 357-368, 2013	526	2013
Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium MY Turco, L Gardner, J Hughes, T Cindrova-Davies, MJ Gomez, L Farrell, ... Nature cell biology 19 (5), 568-577, 2017	523	2017
Modeling mouse and human development using organoid cultures M Huch, BK Koo Development 142 (18), 3113-3125, 2015	519	2015
Controlled gene expression in primary Lgr5 organoid cultures BK Koo, DE Stange, T Sato, W Karthaus, HF Farin, M Huch, JH Van Es, ... Nature methods 9 (1), 81-83, 2012	360	2012
Inflammatory signals induce AT2 cell-derived damage-associated transient progenitors that mediate alveolar regeneration J Choi, JE Park, G Tsagkogeorga, M Yanagita, BK Koo, N Han, JH Lee Cell stem cell 27 (3), 366-382. e7, 2020	329	2020
A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal JH van Es, A Haegebarth, P Kujala, S Itzkovitz, BK Koo, SF Boj, J Korving, ... Molecular and cellular biology, 2012	297	2012
Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts J Schuijers, JP Junker, M Mokry, P Hatzis, BK Koo, V Sasselli, ... Cell stem cell 16 (2), 158-170, 2015	285	2015
Mind bomb 1 is essential for generating functional Notch ligands to activate Notch BK Koo, HS Lim, R Song, MJ Yoon, KJ Yoon, JS Moon, YW Kim, M Kwon, ... Oxford University Press for The Company of Biologists Limited 132 (15), 3459 …, 2005	284	2005
Human gastric cancer modelling using organoids T Seidlitz, SR Merker, A Rothe, F Zakrzewski, C von Neubeck, ... Gut 68 (2), 207-217, 2019	261	2019
DNA methylation and transcription patterns in intestinal epithelial cells from pediatric patients with inflammatory bowel diseases differentiate disease subtypes and associate … KJ Howell, J Kraiczy, KM Nayak, M Gasparetto, A Ross, C Lee, TN Mak, ... Gastroenterology 154 (3), 585-598, 2018	260	2018
Divergent routes toward Wnt and R-spondin niche independency during human gastric carcinogenesis K Nanki, K Toshimitsu, A Takano, M Fujii, M Shimokawa, Y Ohta, ... Cell 174 (4), 856-869. e17, 2018	257	2018
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response J Heijmans, JFL de Jeude, BK Koo, SL Rosekrans, MCB Wielenga, ... Cell reports 3 (4), 1128-1139, 2013	242	2013
A crucial role of WW45 in developing epithelial tissues in the mouse JH Lee, TS Kim, TH Yang, BK Koo, SP Oh, KP Lee, HJ Oh, SH Lee, ... The EMBO journal 27 (8), 1231-1242, 2008	228	2008

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