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Niek Wit
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Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism.
G Burgos-Barragan, N Wit, J Meiser, FA Dingler, M Pietzke, L Mulderrig, ...
Nature 548 (7669), 549, 2017
2782017
Functionally similar WRKY proteins regulate vacuolar acidification in petunia and hair development in Arabidopsis
W Verweij, CE Spelt, M Bliek, M de Vries, N Wit, M Faraco, R Koes, ...
The Plant Cell 28 (3), 786-803, 2016
1382016
Development of a general aza-Cope reaction trigger applied to fluorescence imaging of formaldehyde in living cells
KJ Bruemmer, RR Walvoord, TF Brewer, G Burgos-Barragan, N Wit, ...
Journal of the American Chemical Society 139 (15), 5338-5350, 2017
1262017
Increased formate overflow is a hallmark of oxidative cancer
J Meiser, A Schuster, M Pietzke, J Vande Voorde, D Athineos, K Oizel, ...
Nature communications 9 (1), 1368, 2018
972018
A 2-aza-Cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells
TF Brewer, G Burgos-Barragan, N Wit, KJ Patel, CJ Chang
Chemical Science, 2017
942017
HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: Existence of an alternative E3 ligase
PHL Krijger, KY Lee, N Wit, PCM van den Berk, X Wu, HP Roest, A Maas, ...
DNA repair 10 (4), 438-444, 2011
812011
PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance
PHL Krijger, PCM van den Berk, N Wit, P Langerak, JG Jansen, ...
DNA repair 10 (10), 1051-1059, 2011
602011
Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage
N Wit, OA Buoninfante, P van den Berk, JG Jansen, MA Hogenbirk, ...
Nucleic acids research 43 (1), 282-294, 2015
522015
Redundancy of mammalian Y family DNA polymerases in cellular responses to genomic DNA lesions induced by ultraviolet light
JG Jansen, P Temviriyanukul, N Wit, F Delbos, CA Reynaud, H Jacobs, ...
Nucleic acids research 42 (17), 11071-11082, 2014
432014
The HIF complex recruits the histone methyltransferase SET1B to activate specific hypoxia-inducible genes
BM Ortmann, N Burrows, IT Lobb, E Arnaiz, N Wit, PSJ Bailey, LH Jordon, ...
Nature Genetics 53 (7), 1022-1035, 2021
422021
Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+ Ung2 hybrid pathway
PHL Krijger, A Tsaalbi‐Shtylik, N Wit, PCM van den Berk, N de Wind, ...
European journal of immunology 43 (10), 2765-2770, 2013
382013
Amino acid dependent formaldehyde metabolism in mammals
M Pietzke, G Burgos-Barragan, N Wit, J Tait-Mulder, D Sumpton, ...
Communications Chemistry 3 (1), 78, 2020
192020
A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production
N Wit, E Gogola, JA West, T Vornbäumen, RV Seear, PSJ Bailey, ...
Science Advances 9 (20), eadg2235, 2023
82023
A HIF independent oxygen-sensitive pathway for controlling cholesterol synthesis
AS Dickson, T Pauzaite, E Arnaiz, BM Ortmann, JA West, N Volkmar, ...
Nature Communications 14 (1), 4816, 2023
62023
Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis
C Pereira, GA Arroyo-Martinez, MZ Guo, MS Downey, ER Kelly, KJ Grive, ...
Elife 11, e68677, 2022
62022
The Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination.
PHL Krijger, N Wit, PCM van den Berk, H Jacobs
PloS one 5 (12), e15236-e15236, 2010
42010
Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA
N Wit, PHL Krijger, PC van den Berk, H Jacobs
PloS one 6 (1), 2011
32011
Deubiquitinating enzyme mutagenesis screens identify a USP43 driven HIF-1 transcriptional response
T Pauzaite, N Wit, RV Seear, JA Nathan
bioRxiv, 2024.01. 10.574971, 2024
2024
Hypoxia drives HIF2-dependent macrophage cell cycle entry and susceptibility to lentiviral transduction
B Meng, N Zhao, P Mlcochova, IATM Ferreira, BM Ortmann, T Davis, N Wit, ...
bioRxiv, 2023.12. 15.571908, 2023
2023
T6 Genome-wide mutagenesis screens identify regulators of cellular iron metabolism and ferroptosis
AW Martinelli, N Wit, JA Nathan
Thorax 78 (Suppl 4), A4-A4, 2023
2023
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