Playing the end game: DNA double-strand break repair pathway choice JR Chapman, MRG Taylor, SJ Boulton Molecular cell 47 (4), 497-510, 2012 | 1888 | 2012 |
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase NK Kolas, JR Chapman, S Nakada, J Ylanko, R Chahwan, FD Sweeney, ... Science 318 (5856), 1637-1640, 2007 | 1052 | 2007 |
RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection JR Chapman, P Barral, JB Vannier, V Borel, M Steger, A Tomas-Loba, ... Molecular cell 49 (5), 858-871, 2013 | 730 | 2013 |
DNA helicases Sgs1 and BLM promote DNA double-strand break resection S Gravel, JR Chapman, C Magill, SP Jackson Genes & development 22 (20), 2767-2772, 2008 | 666 | 2008 |
REV7 counteracts DNA double-strand break resection and affects PARP inhibition G Xu, JR Chapman, I Brandsma, J Yuan, M Mistrik, P Bouwman, ... Nature 521 (7553), 541-544, 2015 | 581 | 2015 |
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair FR Day, KS Ruth, DJ Thompson, KL Lunetta, N Pervjakova, DI Chasman, ... Nature genetics 47 (11), 1294-1303, 2015 | 397 | 2015 |
BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair JR Chapman, AJ Sossick, SJ Boulton, SP Jackson Journal of cell science 125 (15), 3529-3534, 2012 | 383 | 2012 |
Phospho‐dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage JR Chapman, SP Jackson EMBO reports 9 (8), 795-801, 2008 | 364 | 2008 |
53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ H Ghezraoui, C Oliveira, JR Becker, K Bilham, D Moralli, C Anzilotti, ... Nature 560 (7716), 122-127, 2018 | 267 | 2018 |
A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage J Lloyd, JR Chapman, JA Clapperton, LF Haire, E Hartsuiker, J Li, ... Cell 139 (1), 100-111, 2009 | 203 | 2009 |
Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair SE Polo, AN Blackford, JR Chapman, L Baskcomb, S Gravel, A Rusch, ... Molecular cell 45 (4), 505-516, 2012 | 202 | 2012 |
H4K20me0 recognition by BRCA1–BARD1 directs homologous recombination to sister chromatids K Nakamura, G Saredi, JR Becker, BM Foster, NV Nguyen, TE Beyer, ... Nature cell biology 21 (3), 311-318, 2019 | 173 | 2019 |
53BP1 integrates DNA repair and p53-dependent cell fate decisions via distinct mechanisms R Cuella-Martin, C Oliveira, HE Lockstone, S Snellenberg, N Grolmusova, ... Molecular cell 64 (1), 51-64, 2016 | 169 | 2016 |
Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility DJ Wright, FR Day, ND Kerrison, F Zink, A Cardona, P Sulem, ... Nature genetics 49 (5), 674-679, 2017 | 143 | 2017 |
The CST complex mediates end protection at double-strand breaks and promotes PARP inhibitor sensitivity in BRCA1-deficient cells M Barazas, S Annunziato, SJ Pettitt, I de Krijger, H Ghezraoui, SJ Roobol, ... Cell reports 23 (7), 2107-2118, 2018 | 136 | 2018 |
An essential role for the Zn2+ transporter ZIP7 in B cell development C Anzilotti, DJ Swan, B Boisson, M Deobagkar-Lele, C Oliveira, ... Nature immunology 20 (3), 350-361, 2019 | 113 | 2019 |
BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination JR Becker, G Clifford, C Bonnet, A Groth, MD Wilson, JR Chapman Nature 596 (7872), 433-437, 2021 | 103 | 2021 |
The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity JR Becker, R Cuella-Martin, M Barazas, R Liu, C Oliveira, AW Oliver, ... Nature communications 9 (1), 5406, 2018 | 92 | 2018 |
A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis N Altemose, N Noor, E Bitoun, A Tumian, M Imbeault, JR Chapman, ... Elife 6, e28383, 2017 | 88 | 2017 |
Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD G Hewitt, V Borel, S Segura-Bayona, T Takaki, P Ruis, R Bellelli, ... Molecular cell 81 (4), 767-783. e11, 2021 | 85 | 2021 |