The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity PV Lishko, E Procko, X Jin, CB Phelps, R Gaudet Neuron 54 (6), 905-918, 2007 | 545 | 2007 |
Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C G Landouré, AA Zdebik, TL Martinez, BG Burnett, HC Stanescu, H Inada, ... Nature genetics 42 (2), 170-174, 2010 | 357 | 2010 |
Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain CB Phelps, RR Wang, SS Choo, R Gaudet Journal of Biological Chemistry 285 (1), 731-740, 2010 | 206 | 2010 |
Mechanism of κB DNA binding by Rel/NF-κB dimers CB Phelps, LL Sengchanthalangsy, S Malek, G Ghosh Journal of Biological Chemistry 275 (32), 24392-24399, 2000 | 176 | 2000 |
Structural Analyses of the Ankyrin Repeat Domain of TRPV6 and Related TRPV Ion Channels, CB Phelps, RJ Huang, PV Lishko, RR Wang, R Gaudet Biochemistry 47 (8), 2476-2484, 2008 | 147 | 2008 |
Mechanism of IκBα binding to NF-κB dimers CB Phelps, LL Sengchanthalangsy, T Huxford, G Ghosh Journal of Biological Chemistry 275 (38), 29840-29846, 2000 | 146 | 2000 |
X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2 DB Huang, YQ Chen, M Ruetsche, CB Phelps, G Ghosh Structure 9 (8), 669-678, 2001 | 112 | 2001 |
The role of the N terminus and transmembrane domain of TRPM8 in channel localization and tetramerization CB Phelps, R Gaudet Journal of Biological Chemistry 282 (50), 36474-36480, 2007 | 109 | 2007 |
Ruthenium promoted on-DNA ring-closing metathesis and cross-metathesis X Lu, L Fan, CB Phelps, CP Davie, CP Donahue Bioconjugate Chemistry 28 (6), 1625-1629, 2017 | 76 | 2017 |
Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening CA Machutta, CS Kollmann, KE Lind, X Bai, PF Chan, J Huang, L Ballell, ... Nature communications 8 (1), 16081, 2017 | 73 | 2017 |
Construction, expression, purification and functional analysis of recombinant NFκB p50/p65 heterodimer FE Chen, S Kempiak, DB Huang, C Phelps, G Ghosh Protein engineering 12 (5), 423-428, 1999 | 73 | 1999 |
Crystal structure of a free κB DNA: insights into DNA recognition by transcription factor NF-κB DB Huang, CB Phelps, AJ Fusco, G Ghosh Journal of molecular biology 346 (1), 147-160, 2005 | 64 | 2005 |
Differential binding of cAMP-dependent protein kinase regulatory subunit isoforms Iα and IIβ to the catalytic subunit X Cheng, C Phelps, SS Taylor Journal of Biological Chemistry 276 (6), 4102-4108, 2001 | 61 | 2001 |
Solvent exposed non-contacting amino acids play a critical role in NF-κB/IκBα complex formation T Huxford, D Mishler, CB Phelps, DB Huang, LL Sengchanthalangsy, ... Journal of molecular biology 324 (4), 587-597, 2002 | 39 | 2002 |
Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels CB Phelps, E Procko, PV Lishko, RR Wang, R Gaudet Channels 1 (3), 148-151, 2007 | 31 | 2007 |
Integration of lead discovery tactics and the evolution of the lead discovery toolbox M Leveridge, CW Chung, JW Gross, CB Phelps, D Green SLAS DISCOVERY: Advancing Life Sciences R&D 23 (9), 881-897, 2018 | 30 | 2018 |
Development of a selection method for discovering irreversible (covalent) binders from a DNA-encoded library Z Zhu, LSC Grady, Y Ding, KE Lind, CP Davie, CB Phelps, G Evindar SLAS DISCOVERY: Advancing the Science of Drug Discovery 24 (2), 169-174, 2019 | 19 | 2019 |
Discreet mutations from c-Rel to v-Rel alter κB DNA recognition, IκBα binding, and dimerization: implications for v-Rel oncogenicity CB Phelps, G Ghosh Oncogene 23 (6), 1229-1238, 2004 | 15 | 2004 |
Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening X Tian, D Suarez, D Thomson, W Li, EA King, L LaFrance, J Boehm, ... Journal of Medicinal Chemistry 65 (21), 14391-14408, 2022 | 7 | 2022 |
DNA-Encoded Library Technology (ELT) G Yao, X Lu, C Phelps, G Evindar | 2 | 2018 |